MFAP4 Deficiency Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysm Formation Through Regulation of Macrophage Infiltration and Activity

MFAP4 Deficiency Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysm Formation Through Regulation of Macrophage Infiltration and Activity

Objective: Abdominal aortic aneurysm (AAA) is a common age-related vascular disease characterized by progressive weakening and dilatation of the aortic wall. Microfibrillar-associated protein 4 (MFAP4) is an extracellular matrix (ECM) protein involved in the induction of vascular remodeling. This st...

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Bibliographic Details
Main Authors: Bartosz Pilecki, Paulo V. S. D. de Carvalho, Katrine L. Kirketerp-Møller, Anders Schlosser, Karin Kejling, Magdalena Dubik, Nicklas P. Madsen, Jane Stubbe, Pernille B. L. Hansen, Thomas L. Andersen, Jesper B. Moeller, Niels Marcussen, Vasco Azevedo, Svend Hvidsten, Christina Baun, Guo-Ping Shi, Jes S. Lindholt, Grith L. Sorensen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
abdominal aortic aneurysm
extracellular matrix
inflammation
macrophage
matrix metalloproteinases
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.764337/full

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