Targeted APC Activation in Cancer Immunotherapy to Enhance the Abscopal Effect
In oncology, the “abscopal effect” refers to the therapeutic effect on a distant tumor resulting from the treatment of local tumor (e. g., ablation, injection, or radiation). Typically associated with radiation, the abscopal effect is thought to be mediated by a systemic antitumor immune response th...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-04-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.00604/full |
| _version_ | 1828403222185771008 |
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| author | Nathan Suek Luis Felipe Campesato Taha Merghoub Taha Merghoub Danny N. Khalil Danny N. Khalil |
| author_facet | Nathan Suek Luis Felipe Campesato Taha Merghoub Taha Merghoub Danny N. Khalil Danny N. Khalil |
| author_sort | Nathan Suek |
| collection | DOAJ |
| description | In oncology, the “abscopal effect” refers to the therapeutic effect on a distant tumor resulting from the treatment of local tumor (e. g., ablation, injection, or radiation). Typically associated with radiation, the abscopal effect is thought to be mediated by a systemic antitumor immune response that is induced by two concurrent changes at the treated tumor: (1) the release of tumor antigens and (2) the exposure of damage-associated molecular patterns. Therapies that produce these changes are associated with immunogenic cell death (ICD). Some interventions have been shown to cause an abscopal effect without inducing the release of tumor antigens, suggesting that release of tumor antigens at baseline plays a significant role in mediating the abscopal effect. With tumor antigens already present, therapies that target activation of APCs alone may be sufficient to enhance the abscopal effect. Here, we discuss two therapies targeted at APC activation, TLR9 and CD40 agonists, and their use in the clinic to enhance the abscopal effect. |
| first_indexed | 2024-12-10T10:14:25Z |
| format | Article |
| id | doaj.art-eb8d504f838246209608f0e390713616 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-10T10:14:25Z |
| publishDate | 2019-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-eb8d504f838246209608f0e3907136162022-12-22T01:53:02ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-04-011010.3389/fimmu.2019.00604430078Targeted APC Activation in Cancer Immunotherapy to Enhance the Abscopal EffectNathan Suek0Luis Felipe Campesato1Taha Merghoub2Taha Merghoub3Danny N. Khalil4Danny N. Khalil5Swim Across America and Ludwig Collaborative Laboratory, Immunology Program, Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY, United StatesSwim Across America and Ludwig Collaborative Laboratory, Immunology Program, Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY, United StatesSwim Across America and Ludwig Collaborative Laboratory, Immunology Program, Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY, United StatesDepartment of Medicine, Weill Cornell Medical College, New York, NY, United StatesSwim Across America and Ludwig Collaborative Laboratory, Immunology Program, Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY, United StatesDepartment of Medicine, Weill Cornell Medical College, New York, NY, United StatesIn oncology, the “abscopal effect” refers to the therapeutic effect on a distant tumor resulting from the treatment of local tumor (e. g., ablation, injection, or radiation). Typically associated with radiation, the abscopal effect is thought to be mediated by a systemic antitumor immune response that is induced by two concurrent changes at the treated tumor: (1) the release of tumor antigens and (2) the exposure of damage-associated molecular patterns. Therapies that produce these changes are associated with immunogenic cell death (ICD). Some interventions have been shown to cause an abscopal effect without inducing the release of tumor antigens, suggesting that release of tumor antigens at baseline plays a significant role in mediating the abscopal effect. With tumor antigens already present, therapies that target activation of APCs alone may be sufficient to enhance the abscopal effect. Here, we discuss two therapies targeted at APC activation, TLR9 and CD40 agonists, and their use in the clinic to enhance the abscopal effect.https://www.frontiersin.org/article/10.3389/fimmu.2019.00604/fullabscopal effectAPC activationDCimmunogenic cell death (ICD)CD40LTLR9 |
| spellingShingle | Nathan Suek Luis Felipe Campesato Taha Merghoub Taha Merghoub Danny N. Khalil Danny N. Khalil Targeted APC Activation in Cancer Immunotherapy to Enhance the Abscopal Effect Frontiers in Immunology abscopal effect APC activation DC immunogenic cell death (ICD) CD40L TLR9 |
| title | Targeted APC Activation in Cancer Immunotherapy to Enhance the Abscopal Effect |
| title_full | Targeted APC Activation in Cancer Immunotherapy to Enhance the Abscopal Effect |
| title_fullStr | Targeted APC Activation in Cancer Immunotherapy to Enhance the Abscopal Effect |
| title_full_unstemmed | Targeted APC Activation in Cancer Immunotherapy to Enhance the Abscopal Effect |
| title_short | Targeted APC Activation in Cancer Immunotherapy to Enhance the Abscopal Effect |
| title_sort | targeted apc activation in cancer immunotherapy to enhance the abscopal effect |
| topic | abscopal effect APC activation DC immunogenic cell death (ICD) CD40L TLR9 |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2019.00604/full |
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