3-Methyladenine prevents energy stress-induced necrotic death of melanoma cells through autophagy-independent mechanisms

3-Methyladenine prevents energy stress-induced necrotic death of melanoma cells through autophagy-independent mechanisms

We investigated the effect of 3-methyladenine (3MA), a class III phosphatidylinositol 3-kinase (PI3K)-blocking autophagy inhibitor, on cancer cell death induced by simultaneous inhibition of glycolysis by 2-deoxyglucose (2DG) and mitochondrial respiration by rotenone. 2DG/rotenone reduced ATP levels...

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Bibliographic Details
Main Authors: Milica Kosic, Verica Paunovic, Biljana Ristic, Aleksandar Mircic, Mihajlo Bosnjak, Danijela Stevanovic, Tamara Kravic-Stevovic, Vladimir Trajkovic, Ljubica Harhaji-Trajkovic
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Journal of Pharmacological Sciences
Subjects:
3-Methyladenine
Glycolysis
Mitochondria
Autophagy
Necrosis
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861321000591

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