SUCCINIC ACID PREPARATIONS IN THE COMBINATION TREATMENT OF PATIENTS WITH TUBERCULOSIS
A simple prospective investigation studied the efficacy of reamberine used to prevent antituberculosis drug-induced hepatitis in 144 patients with new-onset infiltrative pulmonary tuberculosis who were divided into 2 groups: 1) those who received a 1-2-week reamberine cycle (a study group) and 2) th...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2014-06-01
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| Series: | Туберкулез и болезни лёгких |
| Subjects: | |
| Online Access: | https://www.tibl-journal.com/jour/article/view/93 |
| _version_ | 1797700198353338368 |
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| author | A. V. Mordykh O. G. Ivanova L. A. Nagibina S. V. Sitnikov |
| author_facet | A. V. Mordykh O. G. Ivanova L. A. Nagibina S. V. Sitnikov |
| author_sort | A. V. Mordykh |
| collection | DOAJ |
| description | A simple prospective investigation studied the efficacy of reamberine used to prevent antituberculosis drug-induced hepatitis in 144 patients with new-onset infiltrative pulmonary tuberculosis who were divided into 2 groups: 1) those who received a 1-2-week reamberine cycle (a study group) and 2) those who did not (a comparison group). In the study group, arrest of the symptoms of intoxication (by the leukocyte index by 35.3%) occurred in a shorter periods; drug-induced hepatitides, whose course was more favorable, were noted to develop less commonly (16.6 versus 36%). In the study group, therapeutic effectiveness was higher than that in the comparison group in terms of both the decay cavity closure index (by 30.2%) and the bacterial cessation index (by 24.8%), including in patients with multidrug-resistant in the pathogen, decay cavities were closed 13.9% more frequently and bacterial excretion cessation was seen 27.8% more often; transformation to fibrocavernous tuberculosis was also observed less commonly. The findings allow one to recommend the use of reamberine as an agent for the prevention of hepatitis caused by the intake of antituberculosis drugs during patients’ adaptation to chemotherapy (1-2weeks of treatment). |
| first_indexed | 2024-03-12T04:19:28Z |
| format | Article |
| id | doaj.art-eb8e85dc4b7e427697de4d296c5237ab |
| institution | Directory Open Access Journal |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| last_indexed | 2024-03-12T04:19:28Z |
| publishDate | 2014-06-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj.art-eb8e85dc4b7e427697de4d296c5237ab2023-09-03T10:34:32ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062014-06-0106616510.21292/2075-1230-2014-0-6-61-6593SUCCINIC ACID PREPARATIONS IN THE COMBINATION TREATMENT OF PATIENTS WITH TUBERCULOSISA. V. Mordykh0O. G. Ivanova1L. A. Nagibina2S. V. Sitnikov3ГБОУ ВПО «Омская государственная медицинская академия» Минздрава РоссииГБОУ ВПО «Омская государственная медицинская академия» Минздрава РоссииКУЗОО «Клинический противотуберкулезный диспансер № 4», г. ОмскКУЗОО «Клинический противотуберкулезный диспансер № 4», г. ОмскA simple prospective investigation studied the efficacy of reamberine used to prevent antituberculosis drug-induced hepatitis in 144 patients with new-onset infiltrative pulmonary tuberculosis who were divided into 2 groups: 1) those who received a 1-2-week reamberine cycle (a study group) and 2) those who did not (a comparison group). In the study group, arrest of the symptoms of intoxication (by the leukocyte index by 35.3%) occurred in a shorter periods; drug-induced hepatitides, whose course was more favorable, were noted to develop less commonly (16.6 versus 36%). In the study group, therapeutic effectiveness was higher than that in the comparison group in terms of both the decay cavity closure index (by 30.2%) and the bacterial cessation index (by 24.8%), including in patients with multidrug-resistant in the pathogen, decay cavities were closed 13.9% more frequently and bacterial excretion cessation was seen 27.8% more often; transformation to fibrocavernous tuberculosis was also observed less commonly. The findings allow one to recommend the use of reamberine as an agent for the prevention of hepatitis caused by the intake of antituberculosis drugs during patients’ adaptation to chemotherapy (1-2weeks of treatment).https://www.tibl-journal.com/jour/article/view/93инфильтративный туберкулезнежелательные побочные реакциилекарственные поражения печениреамберин |
| spellingShingle | A. V. Mordykh O. G. Ivanova L. A. Nagibina S. V. Sitnikov SUCCINIC ACID PREPARATIONS IN THE COMBINATION TREATMENT OF PATIENTS WITH TUBERCULOSIS Туберкулез и болезни лёгких инфильтративный туберкулез нежелательные побочные реакции лекарственные поражения печени реамберин |
| title | SUCCINIC ACID PREPARATIONS IN THE COMBINATION TREATMENT OF PATIENTS WITH TUBERCULOSIS |
| title_full | SUCCINIC ACID PREPARATIONS IN THE COMBINATION TREATMENT OF PATIENTS WITH TUBERCULOSIS |
| title_fullStr | SUCCINIC ACID PREPARATIONS IN THE COMBINATION TREATMENT OF PATIENTS WITH TUBERCULOSIS |
| title_full_unstemmed | SUCCINIC ACID PREPARATIONS IN THE COMBINATION TREATMENT OF PATIENTS WITH TUBERCULOSIS |
| title_short | SUCCINIC ACID PREPARATIONS IN THE COMBINATION TREATMENT OF PATIENTS WITH TUBERCULOSIS |
| title_sort | succinic acid preparations in the combination treatment of patients with tuberculosis |
| topic | инфильтративный туберкулез нежелательные побочные реакции лекарственные поражения печени реамберин |
| url | https://www.tibl-journal.com/jour/article/view/93 |
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