Interplay between Nucleoid-Associated Proteins and Transcription Factors in Controlling Specialized Metabolism in <italic toggle="yes">Streptomyces</italic>

Interplay between Nucleoid-Associated Proteins and Transcription Factors in Controlling Specialized Metabolism in <italic toggle="yes">Streptomyces</italic>

ABSTRACT Lsr2 is a small nucleoid-associated protein found throughout the actinobacteria. Lsr2 functions similarly to the well-studied H-NS, in that it preferentially binds AT-rich sequences and represses gene expression. In Streptomyces venezuelae, Lsr2 represses the expression of many specialized...

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Bibliographic Details
Main Authors: Xiafei Zhang, Sara N. Andres, Marie A. Elliot
Format: Article
Language:English
Published: American Society for Microbiology 2021-08-01
Series:mBio
Subjects:
Streptomyces
chloramphenicol
antibiotic
countersilencing
nucleoid-associated protein
Lsr2
Online Access:https://journals.asm.org/doi/10.1128/mBio.01077-21

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