Clinical and prognostic significance of baseline microRNA 223 in acute ischemic stroke
Abstract Background Acute ischemic stroke (AIS) is the second leading cause of disability and death worldwide. Micro-RNA (miRNA)-223 was first identified as a regulator of hematopoietic lineage differentiation. Later, its diverse roles were discovered in a wide spectrum of pathological conditions. T...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2024-03-01
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| Series: | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
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| Online Access: | https://doi.org/10.1186/s41983-024-00823-x |
| _version_ | 1797247437736247296 |
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| author | Rasha Elsayed Mohamed Abd El Aziz Wafaa Abdelaziz Emam Fatma M. El-senosy Sammar Ahmed Kasim Marwa A. A. Ramadan Fatima G. Yehia Sabah M. Alkhawagah Rasha Sobhy ElAttar Ahmed Elsaid Elsayed Amena Rezk Mohammed |
| author_facet | Rasha Elsayed Mohamed Abd El Aziz Wafaa Abdelaziz Emam Fatma M. El-senosy Sammar Ahmed Kasim Marwa A. A. Ramadan Fatima G. Yehia Sabah M. Alkhawagah Rasha Sobhy ElAttar Ahmed Elsaid Elsayed Amena Rezk Mohammed |
| author_sort | Rasha Elsayed Mohamed Abd El Aziz |
| collection | DOAJ |
| description | Abstract Background Acute ischemic stroke (AIS) is the second leading cause of disability and death worldwide. Micro-RNA (miRNA)-223 was first identified as a regulator of hematopoietic lineage differentiation. Later, its diverse roles were discovered in a wide spectrum of pathological conditions. The present study aimed to assess the clinical and prognostic significance of miR-223 in patients with acute ischemic stroke (AIS). The study included 93 patients with AIS diagnosed on the basis of clinical and radiological findings. In addition, there were 50 healthy subjects who served as controls. Patients were classified into two categories: Those with favorable functional outcome (modified Rankin Scale (mRS): 0–2) and others with unfavorable functional outcome (mRS: 3–6) at 6 months post-stroke. Results The present prospective longitudinal study included 93 patients with AIS. They included 60 males (64.5%) and 33 females (35.5%) with an age of 64.5 ± 12.4 years. At the end of 6-month follow up, 44 patients (47.3%) had favorable outcome while the remainder 49 patients (52.7%) had unfavorable outcome. Patients with favorable outcome had significantly lower baseline miR-223 levels [median (IQR): 4.4 (2.0–6.3) versus 8.4 (4.5–14.9), p < 0.001], lower HbA1c levels (5.6 ± 1.0 versus 6.2 ± 1.2, p = 0.006) and lower C-reactive protein (CRP) levels [median (IQR): 8.9 (5.1–26.7) versus 15.2 (6.2–39.3) mg/dL, p = 0.02]. Multivariate binary logistic regression analysis recognized high baseline miR-223 [OR (95% CI) 1.13 (1.06–1.24), p = 0.011], infarct size [OR (95% CI) 2.58 (1.66–4.77), p = 0.001] and National Institutes of Health Stroke Scale (NIHSS) [OR (95% CI) 2.11 (1.74–3.09), p = 0.004] as significant predictors of unfavorable outcome in the studied patients. Conclusions Elevated baseline miR-223 levels are associated with high NIHSS and larger infarct size at baseline and can effectively predict patients’ outcome at 6-months post-stroke. |
| first_indexed | 2024-04-24T19:58:41Z |
| format | Article |
| id | doaj.art-eb94a13032244ee3921152b21dffefa5 |
| institution | Directory Open Access Journal |
| issn | 1687-8329 |
| language | English |
| last_indexed | 2024-04-24T19:58:41Z |
| publishDate | 2024-03-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| spelling | doaj.art-eb94a13032244ee3921152b21dffefa52024-03-24T12:13:47ZengSpringerOpenThe Egyptian Journal of Neurology, Psychiatry and Neurosurgery1687-83292024-03-016011610.1186/s41983-024-00823-xClinical and prognostic significance of baseline microRNA 223 in acute ischemic strokeRasha Elsayed Mohamed Abd El Aziz0Wafaa Abdelaziz Emam1Fatma M. El-senosy2Sammar Ahmed Kasim3Marwa A. A. Ramadan4Fatima G. Yehia5Sabah M. Alkhawagah6Rasha Sobhy ElAttar7Ahmed Elsaid Elsayed8Amena Rezk Mohammed9Biochemistry Department, Faculty of Medicine (for Girls), Al-Azhar UniversityBiochemistry Department, Faculty of Medicine (for Girls), Al-Azhar UniversityInternal Medicine Department, Faculty of Medicine (for Girls), Al-Azhar UniversityInternal Medicine Department, Faculty of Medicine (for Girls), Al-Azhar UniversityClinical Pathology Department, Faculty of Medicine (for Girls), Al-Azhar UniversityClinical Pathology Department, Faculty of Medicine (for Girls), Al-Azhar UniversityMedical Microbiology and Immunology, Faculty of Medicine (for Girls), Al-Azhar UniversityNeurology Department, Faculty of Medicine (for Girls), Al-Azhar UniversityNeurology Department, Military Medical AcademyBiochemistry Department, Faculty of Medicine (for Girls), Al-Azhar UniversityAbstract Background Acute ischemic stroke (AIS) is the second leading cause of disability and death worldwide. Micro-RNA (miRNA)-223 was first identified as a regulator of hematopoietic lineage differentiation. Later, its diverse roles were discovered in a wide spectrum of pathological conditions. The present study aimed to assess the clinical and prognostic significance of miR-223 in patients with acute ischemic stroke (AIS). The study included 93 patients with AIS diagnosed on the basis of clinical and radiological findings. In addition, there were 50 healthy subjects who served as controls. Patients were classified into two categories: Those with favorable functional outcome (modified Rankin Scale (mRS): 0–2) and others with unfavorable functional outcome (mRS: 3–6) at 6 months post-stroke. Results The present prospective longitudinal study included 93 patients with AIS. They included 60 males (64.5%) and 33 females (35.5%) with an age of 64.5 ± 12.4 years. At the end of 6-month follow up, 44 patients (47.3%) had favorable outcome while the remainder 49 patients (52.7%) had unfavorable outcome. Patients with favorable outcome had significantly lower baseline miR-223 levels [median (IQR): 4.4 (2.0–6.3) versus 8.4 (4.5–14.9), p < 0.001], lower HbA1c levels (5.6 ± 1.0 versus 6.2 ± 1.2, p = 0.006) and lower C-reactive protein (CRP) levels [median (IQR): 8.9 (5.1–26.7) versus 15.2 (6.2–39.3) mg/dL, p = 0.02]. Multivariate binary logistic regression analysis recognized high baseline miR-223 [OR (95% CI) 1.13 (1.06–1.24), p = 0.011], infarct size [OR (95% CI) 2.58 (1.66–4.77), p = 0.001] and National Institutes of Health Stroke Scale (NIHSS) [OR (95% CI) 2.11 (1.74–3.09), p = 0.004] as significant predictors of unfavorable outcome in the studied patients. Conclusions Elevated baseline miR-223 levels are associated with high NIHSS and larger infarct size at baseline and can effectively predict patients’ outcome at 6-months post-stroke.https://doi.org/10.1186/s41983-024-00823-xAcute ischemic strokeMicroRNAsmiR-223National Institutes of Health Stroke Scale |
| spellingShingle | Rasha Elsayed Mohamed Abd El Aziz Wafaa Abdelaziz Emam Fatma M. El-senosy Sammar Ahmed Kasim Marwa A. A. Ramadan Fatima G. Yehia Sabah M. Alkhawagah Rasha Sobhy ElAttar Ahmed Elsaid Elsayed Amena Rezk Mohammed Clinical and prognostic significance of baseline microRNA 223 in acute ischemic stroke The Egyptian Journal of Neurology, Psychiatry and Neurosurgery Acute ischemic stroke MicroRNAs miR-223 National Institutes of Health Stroke Scale |
| title | Clinical and prognostic significance of baseline microRNA 223 in acute ischemic stroke |
| title_full | Clinical and prognostic significance of baseline microRNA 223 in acute ischemic stroke |
| title_fullStr | Clinical and prognostic significance of baseline microRNA 223 in acute ischemic stroke |
| title_full_unstemmed | Clinical and prognostic significance of baseline microRNA 223 in acute ischemic stroke |
| title_short | Clinical and prognostic significance of baseline microRNA 223 in acute ischemic stroke |
| title_sort | clinical and prognostic significance of baseline microrna 223 in acute ischemic stroke |
| topic | Acute ischemic stroke MicroRNAs miR-223 National Institutes of Health Stroke Scale |
| url | https://doi.org/10.1186/s41983-024-00823-x |
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