Evolution of drug resistance in HIV protease

Evolution of drug resistance in HIV protease

Abstract Background Drug resistance is a critical problem limiting effective antiviral therapy for HIV/AIDS. Computational techniques for predicting drug resistance profiles from genomic data can accelerate the appropriate choice of therapy. These techniques can also be used to identify protease mut...

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Bibliographic Details
Main Authors: Dhara Shah, Christopher Freas, Irene T. Weber, Robert W. Harrison
Format: Article
Language:English
Published: BMC 2020-12-01
Series:BMC Bioinformatics
Subjects:
HIV protease
Drug resistance
Machine learning
Evolution
Structure-based
Online Access:https://doi.org/10.1186/s12859-020-03825-7

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