Male Infertility in the XXI Century: Are Obesogens to Blame?
The permanent exposure to environmental contaminants promoting weight gain (i.e., obesogens) has raised serious health concerns. Evidence suggests that obesogens are one of the leading causes of the marked decline in male fertility and are key players in shaping future health outcomes, not only for...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/6/3046 |
| _version_ | 1797471036928688128 |
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| author | Ana C. A. Sousa Marco G. Alves Pedro F. Oliveira Branca M. Silva Luís Rato |
| author_facet | Ana C. A. Sousa Marco G. Alves Pedro F. Oliveira Branca M. Silva Luís Rato |
| author_sort | Ana C. A. Sousa |
| collection | DOAJ |
| description | The permanent exposure to environmental contaminants promoting weight gain (i.e., obesogens) has raised serious health concerns. Evidence suggests that obesogens are one of the leading causes of the marked decline in male fertility and are key players in shaping future health outcomes, not only for those who are directly exposed to them, but also for upcoming generations. It has been hypothesized that obesogens affect male fertility. By using an interdisciplinary strategy, combining in silico, in vitro, in vivo and epidemiological findings, this review aims to contribute to the biological understanding of the molecular transformations induced by obesogens that are the basis of male infertility. Such understanding is shaped by the use of Adverse Outcomes Pathways, a new approach that may shift the paradigm of reproductive toxicology, contributing to the improvement of the diagnosis and management of the adverse effects of obesogens in male fertility. |
| first_indexed | 2024-03-09T19:43:52Z |
| format | Article |
| id | doaj.art-eb96e24257c54e468ca067b26d40d3a2 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T19:43:52Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-eb96e24257c54e468ca067b26d40d3a22023-11-24T01:31:08ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-03-01236304610.3390/ijms23063046Male Infertility in the XXI Century: Are Obesogens to Blame?Ana C. A. Sousa0Marco G. Alves1Pedro F. Oliveira2Branca M. Silva3Luís Rato4Department of Biology, School of Science and Technology, University of Évora, 7006-554 Évora, PortugalDepartment of Anatomy, Unit for Multidisciplinary Research in Biomedicine (UMIB), Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, 4050-523 Porto, PortugalDepartment of Chemistry, QOPNA & LAQV, University of Aveiro, 3810-193 Aveiro, PortugalFaculty of Health Sciences, University of Beira Interior, Rua Marquês d’Ávila e Bolama, 6200-001 Covilhã, PortugalFaculty of Health Sciences, University of Beira Interior, Rua Marquês d’Ávila e Bolama, 6200-001 Covilhã, PortugalThe permanent exposure to environmental contaminants promoting weight gain (i.e., obesogens) has raised serious health concerns. Evidence suggests that obesogens are one of the leading causes of the marked decline in male fertility and are key players in shaping future health outcomes, not only for those who are directly exposed to them, but also for upcoming generations. It has been hypothesized that obesogens affect male fertility. By using an interdisciplinary strategy, combining in silico, in vitro, in vivo and epidemiological findings, this review aims to contribute to the biological understanding of the molecular transformations induced by obesogens that are the basis of male infertility. Such understanding is shaped by the use of Adverse Outcomes Pathways, a new approach that may shift the paradigm of reproductive toxicology, contributing to the improvement of the diagnosis and management of the adverse effects of obesogens in male fertility.https://www.mdpi.com/1422-0067/23/6/3046endocrine disruptorsmale fertilityobesogensadverse outcomes pathwaystesticular metabolismSertoli cells |
| spellingShingle | Ana C. A. Sousa Marco G. Alves Pedro F. Oliveira Branca M. Silva Luís Rato Male Infertility in the XXI Century: Are Obesogens to Blame? International Journal of Molecular Sciences endocrine disruptors male fertility obesogens adverse outcomes pathways testicular metabolism Sertoli cells |
| title | Male Infertility in the XXI Century: Are Obesogens to Blame? |
| title_full | Male Infertility in the XXI Century: Are Obesogens to Blame? |
| title_fullStr | Male Infertility in the XXI Century: Are Obesogens to Blame? |
| title_full_unstemmed | Male Infertility in the XXI Century: Are Obesogens to Blame? |
| title_short | Male Infertility in the XXI Century: Are Obesogens to Blame? |
| title_sort | male infertility in the xxi century are obesogens to blame |
| topic | endocrine disruptors male fertility obesogens adverse outcomes pathways testicular metabolism Sertoli cells |
| url | https://www.mdpi.com/1422-0067/23/6/3046 |
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