Secretion of full-length Tau or Tau fragments in cell culture models. Propagation of Tau in vivo and in vitro
The microtubule-associated protein Tau plays a crucial role in stabilizing neuronal microtubules. In Tauopathies, Tau loses its ability to bind microtubules, detach from them and forms intracellular aggregates. Increasing evidence in recent years supports the notion that Tau pathology spreading thro...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2018-03-01
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| Series: | Biomolecular Concepts |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/bmc-2018-0001 |
| _version_ | 1818729523564249088 |
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| author | Pérez Mar Medina Miguel Hernández Félix Avila Jesús |
| author_facet | Pérez Mar Medina Miguel Hernández Félix Avila Jesús |
| author_sort | Pérez Mar |
| collection | DOAJ |
| description | The microtubule-associated protein Tau plays a crucial role in stabilizing neuronal microtubules. In Tauopathies, Tau loses its ability to bind microtubules, detach from them and forms intracellular aggregates. Increasing evidence in recent years supports the notion that Tau pathology spreading throughout the brain in AD and other Tauopathies is the consequence of the propagation of specific Tau species along neuroanatomically connected brain regions in a so-called “prion-like” manner. A number of steps are assumed to be involved in this process, including secretion, cellular uptake, transcellular transfer and/or seeding, although the precise mechanisms underlying propagation of Tau pathology are not fully understood yet. This review summarizes recent evidence on the nature of the specific Tau species that are propagated and the different mechanisms of Tau pathology spreading. |
| first_indexed | 2024-12-17T22:47:15Z |
| format | Article |
| id | doaj.art-eb96f5cfb3b3475fa96dbe6da68cb957 |
| institution | Directory Open Access Journal |
| issn | 1868-5021 1868-503X |
| language | English |
| last_indexed | 2024-12-17T22:47:15Z |
| publishDate | 2018-03-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Biomolecular Concepts |
| spelling | doaj.art-eb96f5cfb3b3475fa96dbe6da68cb9572022-12-21T21:29:46ZengDe GruyterBiomolecular Concepts1868-50211868-503X2018-03-019111110.1515/bmc-2018-0001bmc-2018-0001Secretion of full-length Tau or Tau fragments in cell culture models. Propagation of Tau in vivo and in vitroPérez Mar0Medina Miguel1Hernández Félix2Avila Jesús3Departamento de Anatomía Histología y Neurociencia, Facultad de Medicina UAM, 28029Madrid, SpainNetwork Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), 28031Madrid, SpainNetwork Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), 28031Madrid, SpainNetwork Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), 28031Madrid, SpainThe microtubule-associated protein Tau plays a crucial role in stabilizing neuronal microtubules. In Tauopathies, Tau loses its ability to bind microtubules, detach from them and forms intracellular aggregates. Increasing evidence in recent years supports the notion that Tau pathology spreading throughout the brain in AD and other Tauopathies is the consequence of the propagation of specific Tau species along neuroanatomically connected brain regions in a so-called “prion-like” manner. A number of steps are assumed to be involved in this process, including secretion, cellular uptake, transcellular transfer and/or seeding, although the precise mechanisms underlying propagation of Tau pathology are not fully understood yet. This review summarizes recent evidence on the nature of the specific Tau species that are propagated and the different mechanisms of Tau pathology spreading.https://doi.org/10.1515/bmc-2018-0001secretionspreadingtautauopathies |
| spellingShingle | Pérez Mar Medina Miguel Hernández Félix Avila Jesús Secretion of full-length Tau or Tau fragments in cell culture models. Propagation of Tau in vivo and in vitro Biomolecular Concepts secretion spreading tau tauopathies |
| title | Secretion of full-length Tau or Tau fragments in cell culture models. Propagation of Tau in vivo and in vitro |
| title_full | Secretion of full-length Tau or Tau fragments in cell culture models. Propagation of Tau in vivo and in vitro |
| title_fullStr | Secretion of full-length Tau or Tau fragments in cell culture models. Propagation of Tau in vivo and in vitro |
| title_full_unstemmed | Secretion of full-length Tau or Tau fragments in cell culture models. Propagation of Tau in vivo and in vitro |
| title_short | Secretion of full-length Tau or Tau fragments in cell culture models. Propagation of Tau in vivo and in vitro |
| title_sort | secretion of full length tau or tau fragments in cell culture models propagation of tau in vivo and in vitro |
| topic | secretion spreading tau tauopathies |
| url | https://doi.org/10.1515/bmc-2018-0001 |
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