Imprinted lncRNA Dio3os preprograms intergenerational brown fat development and obesity resistance
Maternal obesity predisposes offspring to obesity and metabolic disorders through incompletely understood mechanisms. Here the authors report that Dio3os is an imprinted long-coding RNA that modulates brown adipose tissue development and obesity resistance in the offspring.
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-27171-1 |
| _version_ | 1819014161897619456 |
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| author | Yan-Ting Chen Qi-Yuan Yang Yun Hu Xiang-Dong Liu Jeanene M. de Avila Mei-Jun Zhu Peter W. Nathanielsz Min Du |
| author_facet | Yan-Ting Chen Qi-Yuan Yang Yun Hu Xiang-Dong Liu Jeanene M. de Avila Mei-Jun Zhu Peter W. Nathanielsz Min Du |
| author_sort | Yan-Ting Chen |
| collection | DOAJ |
| description | Maternal obesity predisposes offspring to obesity and metabolic disorders through incompletely understood mechanisms. Here the authors report that Dio3os is an imprinted long-coding RNA that modulates brown adipose tissue development and obesity resistance in the offspring. |
| first_indexed | 2024-12-21T02:11:27Z |
| format | Article |
| id | doaj.art-eb977fb03c8d4446a9e5238f5e98ccbc |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-21T02:11:27Z |
| publishDate | 2021-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-eb977fb03c8d4446a9e5238f5e98ccbc2022-12-21T19:19:22ZengNature PortfolioNature Communications2041-17232021-11-0112111810.1038/s41467-021-27171-1Imprinted lncRNA Dio3os preprograms intergenerational brown fat development and obesity resistanceYan-Ting Chen0Qi-Yuan Yang1Yun Hu2Xiang-Dong Liu3Jeanene M. de Avila4Mei-Jun Zhu5Peter W. Nathanielsz6Min Du7Nutrigenomics and Growth Biology Laboratory, Department of Animal Sciences, Washington State UniversityNutrigenomics and Growth Biology Laboratory, Department of Animal Sciences, Washington State UniversityNutrigenomics and Growth Biology Laboratory, Department of Animal Sciences, Washington State UniversityNutrigenomics and Growth Biology Laboratory, Department of Animal Sciences, Washington State UniversityNutrigenomics and Growth Biology Laboratory, Department of Animal Sciences, Washington State UniversitySchool of Food Sciences, Washington State UniversityWyoming Pregnancy and Life Course Health Center, Department of Animal Science, University of WyomingNutrigenomics and Growth Biology Laboratory, Department of Animal Sciences, Washington State UniversityMaternal obesity predisposes offspring to obesity and metabolic disorders through incompletely understood mechanisms. Here the authors report that Dio3os is an imprinted long-coding RNA that modulates brown adipose tissue development and obesity resistance in the offspring.https://doi.org/10.1038/s41467-021-27171-1 |
| spellingShingle | Yan-Ting Chen Qi-Yuan Yang Yun Hu Xiang-Dong Liu Jeanene M. de Avila Mei-Jun Zhu Peter W. Nathanielsz Min Du Imprinted lncRNA Dio3os preprograms intergenerational brown fat development and obesity resistance Nature Communications |
| title | Imprinted lncRNA Dio3os preprograms intergenerational brown fat development and obesity resistance |
| title_full | Imprinted lncRNA Dio3os preprograms intergenerational brown fat development and obesity resistance |
| title_fullStr | Imprinted lncRNA Dio3os preprograms intergenerational brown fat development and obesity resistance |
| title_full_unstemmed | Imprinted lncRNA Dio3os preprograms intergenerational brown fat development and obesity resistance |
| title_short | Imprinted lncRNA Dio3os preprograms intergenerational brown fat development and obesity resistance |
| title_sort | imprinted lncrna dio3os preprograms intergenerational brown fat development and obesity resistance |
| url | https://doi.org/10.1038/s41467-021-27171-1 |
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