The Importance of CXCL1 in the Physiological State and in Noncancer Diseases of the Oral Cavity and Abdominal Organs
CXCL1 is a CXC chemokine, CXCR2 ligand and chemotactic factor for neutrophils. In this paper, we present a review of the role of the chemokine CXCL1 in physiology and in selected major non-cancer diseases of the oral cavity and abdominal organs (gingiva, salivary glands, stomach, liver, pancreas, in...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/13/7151 |
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| author | Jan Korbecki Iwona Szatkowska Patrycja Kupnicka Wojciech Żwierełło Katarzyna Barczak Iwona Poziomkowska-Gęsicka Jerzy Wójcik Dariusz Chlubek Irena Baranowska-Bosiacka |
| author_facet | Jan Korbecki Iwona Szatkowska Patrycja Kupnicka Wojciech Żwierełło Katarzyna Barczak Iwona Poziomkowska-Gęsicka Jerzy Wójcik Dariusz Chlubek Irena Baranowska-Bosiacka |
| author_sort | Jan Korbecki |
| collection | DOAJ |
| description | CXCL1 is a CXC chemokine, CXCR2 ligand and chemotactic factor for neutrophils. In this paper, we present a review of the role of the chemokine CXCL1 in physiology and in selected major non-cancer diseases of the oral cavity and abdominal organs (gingiva, salivary glands, stomach, liver, pancreas, intestines, and kidneys). We focus on the importance of CXCL1 on implantation and placentation as well as on human pluripotent stem cells. We also show the significance of CXCL1 in selected diseases of the abdominal organs, including the gastrointestinal tract and oral cavity (periodontal diseases, periodontitis, Sjögren syndrome, <i>Helicobacter pylori</i> infection, diabetes, liver cirrhosis, alcoholic liver disease (ALD), non-alcoholic fatty liver disease (NAFLD), HBV and HCV infection, liver ischemia and reperfusion injury, inflammatory bowel disease (Crohn’s disease and ulcerative colitis), obesity and overweight, kidney transplantation and ischemic-reperfusion injury, endometriosis and adenomyosis). |
| first_indexed | 2024-03-09T21:50:24Z |
| format | Article |
| id | doaj.art-eb984fc41b3149f2a84fa57405b34421 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T21:50:24Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-eb984fc41b3149f2a84fa57405b344212023-11-23T20:08:55ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-06-012313715110.3390/ijms23137151The Importance of CXCL1 in the Physiological State and in Noncancer Diseases of the Oral Cavity and Abdominal OrgansJan Korbecki0Iwona Szatkowska1Patrycja Kupnicka2Wojciech Żwierełło3Katarzyna Barczak4Iwona Poziomkowska-Gęsicka5Jerzy Wójcik6Dariusz Chlubek7Irena Baranowska-Bosiacka8Department of Biochemistry and Medical Chemistry, Pomeranian Medical University in Szczecin, Powstańców Wlkp. 72 Av., 70-111 Szczecin, PolandDepartment of Ruminants Science, Faculty of Biotechnology and Animal Husbandry, West Pomeranian University of Technology, Klemensa Janickiego 29 St., 71-270 Szczecin, PolandDepartment of Biochemistry and Medical Chemistry, Pomeranian Medical University in Szczecin, Powstańców Wlkp. 72 Av., 70-111 Szczecin, PolandDepartment of Medical Chemistry, Pomeranian Medical University in Szczecin, Powstańców Wlkp. 72 Av., 70-111 Szczecin, PolandDepartment of Conservative Dentistry and Endodontics, Pomeranian Medical University, Powstańców Wlkp 72, 70-111 Szczecin, PolandClinical Allergology Department, Pomeranian Medical University in Szczecin, Powstańców Wlkp. 72 Av., 70-111 Szczecin, PolandDepartment of Ruminants Science, Faculty of Biotechnology and Animal Husbandry, West Pomeranian University of Technology, Klemensa Janickiego 29 St., 71-270 Szczecin, PolandDepartment of Biochemistry and Medical Chemistry, Pomeranian Medical University in Szczecin, Powstańców Wlkp. 72 Av., 70-111 Szczecin, PolandDepartment of Biochemistry and Medical Chemistry, Pomeranian Medical University in Szczecin, Powstańców Wlkp. 72 Av., 70-111 Szczecin, PolandCXCL1 is a CXC chemokine, CXCR2 ligand and chemotactic factor for neutrophils. In this paper, we present a review of the role of the chemokine CXCL1 in physiology and in selected major non-cancer diseases of the oral cavity and abdominal organs (gingiva, salivary glands, stomach, liver, pancreas, intestines, and kidneys). We focus on the importance of CXCL1 on implantation and placentation as well as on human pluripotent stem cells. We also show the significance of CXCL1 in selected diseases of the abdominal organs, including the gastrointestinal tract and oral cavity (periodontal diseases, periodontitis, Sjögren syndrome, <i>Helicobacter pylori</i> infection, diabetes, liver cirrhosis, alcoholic liver disease (ALD), non-alcoholic fatty liver disease (NAFLD), HBV and HCV infection, liver ischemia and reperfusion injury, inflammatory bowel disease (Crohn’s disease and ulcerative colitis), obesity and overweight, kidney transplantation and ischemic-reperfusion injury, endometriosis and adenomyosis).https://www.mdpi.com/1422-0067/23/13/7151CXCL1CXCR2chemokinecytokineneutrophilMIP-2 |
| spellingShingle | Jan Korbecki Iwona Szatkowska Patrycja Kupnicka Wojciech Żwierełło Katarzyna Barczak Iwona Poziomkowska-Gęsicka Jerzy Wójcik Dariusz Chlubek Irena Baranowska-Bosiacka The Importance of CXCL1 in the Physiological State and in Noncancer Diseases of the Oral Cavity and Abdominal Organs International Journal of Molecular Sciences CXCL1 CXCR2 chemokine cytokine neutrophil MIP-2 |
| title | The Importance of CXCL1 in the Physiological State and in Noncancer Diseases of the Oral Cavity and Abdominal Organs |
| title_full | The Importance of CXCL1 in the Physiological State and in Noncancer Diseases of the Oral Cavity and Abdominal Organs |
| title_fullStr | The Importance of CXCL1 in the Physiological State and in Noncancer Diseases of the Oral Cavity and Abdominal Organs |
| title_full_unstemmed | The Importance of CXCL1 in the Physiological State and in Noncancer Diseases of the Oral Cavity and Abdominal Organs |
| title_short | The Importance of CXCL1 in the Physiological State and in Noncancer Diseases of the Oral Cavity and Abdominal Organs |
| title_sort | importance of cxcl1 in the physiological state and in noncancer diseases of the oral cavity and abdominal organs |
| topic | CXCL1 CXCR2 chemokine cytokine neutrophil MIP-2 |
| url | https://www.mdpi.com/1422-0067/23/13/7151 |
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