Differentiating brain metastasis from glioblastoma by time-dependent diffusion MRI
Abstract Background This study was designed to investigate the use of time-dependent diffusion magnetic resonance imaging (MRI) parameters in distinguishing between glioblastomas and brain metastases. Methods A retrospective study was conducted involving 65 patients with glioblastomas and 27 patient...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | Cancer Imaging |
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| Online Access: | https://doi.org/10.1186/s40644-023-00595-2 |
| _version_ | 1797451722468098048 |
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| author | Kiyohisa Kamimura Yoshiki Kamimura Tsubasa Nakano Tomohito Hasegawa Masanori Nakajo Chihiro Yamada Kentaro Akune Fumitaka Ejima Takuro Ayukawa Soichiro Ito Hiroaki Nagano Koji Takumi Masatoyo Nakajo Hiroyuki Uchida Kazuhiro Tabata Takashi Iwanaga Hiroshi Imai Thorsten Feiweier Takashi Yoshiura |
| author_facet | Kiyohisa Kamimura Yoshiki Kamimura Tsubasa Nakano Tomohito Hasegawa Masanori Nakajo Chihiro Yamada Kentaro Akune Fumitaka Ejima Takuro Ayukawa Soichiro Ito Hiroaki Nagano Koji Takumi Masatoyo Nakajo Hiroyuki Uchida Kazuhiro Tabata Takashi Iwanaga Hiroshi Imai Thorsten Feiweier Takashi Yoshiura |
| author_sort | Kiyohisa Kamimura |
| collection | DOAJ |
| description | Abstract Background This study was designed to investigate the use of time-dependent diffusion magnetic resonance imaging (MRI) parameters in distinguishing between glioblastomas and brain metastases. Methods A retrospective study was conducted involving 65 patients with glioblastomas and 27 patients with metastases using a diffusion-weighted imaging sequence with oscillating gradient spin-echo (OGSE, 50 Hz) and a conventional pulsed gradient spin-echo (PGSE, 0 Hz) sequence. In addition to apparent diffusion coefficient (ADC) maps from two sequences (ADC50Hz and ADC0Hz), we generated maps of the ADC change (cADC): ADC50Hz − ADC0Hz and the relative ADC change (rcADC): (ADC50Hz − ADC0Hz)/ ADC0Hz × 100 (%). Results The mean and the fifth and 95th percentile values of each parameter in enhancing and peritumoral regions were compared between glioblastomas and metastases. The area under the receiver operating characteristic curve (AUC) values of the best discriminating indices were compared. In enhancing regions, none of the indices of ADC0Hz and ADC50Hz showed significant differences between metastases and glioblastomas. The mean cADC and rcADC values of metastases were significantly higher than those of glioblastomas (0.24 ± 0.12 × 10−3mm2/s vs. 0.14 ± 0.03 × 10−3mm2/s and 23.3 ± 9.4% vs. 14.0 ± 4.7%; all p < 0.01). In peritumoral regions, no significant difference in all ADC indices was observed between metastases and glioblastomas. The AUC values for the mean cADC (0.877) and rcADC (0.819) values in enhancing regions were significantly higher than those for ADC0Hz 5th (0.595; all p < 0.001). Conclusions The time-dependent diffusion MRI parameters may be useful for differentiating brain metastases from glioblastomas. |
| first_indexed | 2024-03-09T14:57:36Z |
| format | Article |
| id | doaj.art-eb989119e3c44131b2d86069e5cd8165 |
| institution | Directory Open Access Journal |
| issn | 1470-7330 |
| language | English |
| last_indexed | 2024-03-09T14:57:36Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Imaging |
| spelling | doaj.art-eb989119e3c44131b2d86069e5cd81652023-11-26T14:06:12ZengBMCCancer Imaging1470-73302023-08-0123111310.1186/s40644-023-00595-2Differentiating brain metastasis from glioblastoma by time-dependent diffusion MRIKiyohisa Kamimura0Yoshiki Kamimura1Tsubasa Nakano2Tomohito Hasegawa3Masanori Nakajo4Chihiro Yamada5Kentaro Akune6Fumitaka Ejima7Takuro Ayukawa8Soichiro Ito9Hiroaki Nagano10Koji Takumi11Masatoyo Nakajo12Hiroyuki Uchida13Kazuhiro Tabata14Takashi Iwanaga15Hiroshi Imai16Thorsten Feiweier17Takashi Yoshiura18Department of Advanced Radiological Imaging, Kagoshima University Graduate School of Medical and Dental SciencesDepartment of Radiology, Kagoshima University Graduate School of Medical and Dental SciencesDepartment of Radiology, Kagoshima University Graduate School of Medical and Dental SciencesDepartment of Radiology, Kagoshima University Graduate School of Medical and Dental SciencesDepartment of Radiology, Kagoshima University Graduate School of Medical and Dental SciencesDepartment of Radiology, Kagoshima University Graduate School of Medical and Dental SciencesDepartment of Radiology, Kagoshima University Graduate School of Medical and Dental SciencesDepartment of Radiology, Kagoshima University Graduate School of Medical and Dental SciencesDepartment of Radiology, Kagoshima University Graduate School of Medical and Dental SciencesDepartment of Radiology, Kagoshima University Graduate School of Medical and Dental SciencesDepartment of Radiology, Kagoshima University Graduate School of Medical and Dental SciencesDepartment of Radiology, Kagoshima University Graduate School of Medical and Dental SciencesDepartment of Radiology, Kagoshima University Graduate School of Medical and Dental SciencesDepartment of Neurosurgery, Kagoshima University Graduate School of Medical and Dental SciencesDepartment of Pathology, Kagoshima University Graduate School of Medical and Dental SciencesDepartment of Radiological Technology, Kagoshima University HospitalSiemens Healthcare K.K., Gate City Osaki West TowerSiemens Healthcare GmbHDepartment of Advanced Radiological Imaging, Kagoshima University Graduate School of Medical and Dental SciencesAbstract Background This study was designed to investigate the use of time-dependent diffusion magnetic resonance imaging (MRI) parameters in distinguishing between glioblastomas and brain metastases. Methods A retrospective study was conducted involving 65 patients with glioblastomas and 27 patients with metastases using a diffusion-weighted imaging sequence with oscillating gradient spin-echo (OGSE, 50 Hz) and a conventional pulsed gradient spin-echo (PGSE, 0 Hz) sequence. In addition to apparent diffusion coefficient (ADC) maps from two sequences (ADC50Hz and ADC0Hz), we generated maps of the ADC change (cADC): ADC50Hz − ADC0Hz and the relative ADC change (rcADC): (ADC50Hz − ADC0Hz)/ ADC0Hz × 100 (%). Results The mean and the fifth and 95th percentile values of each parameter in enhancing and peritumoral regions were compared between glioblastomas and metastases. The area under the receiver operating characteristic curve (AUC) values of the best discriminating indices were compared. In enhancing regions, none of the indices of ADC0Hz and ADC50Hz showed significant differences between metastases and glioblastomas. The mean cADC and rcADC values of metastases were significantly higher than those of glioblastomas (0.24 ± 0.12 × 10−3mm2/s vs. 0.14 ± 0.03 × 10−3mm2/s and 23.3 ± 9.4% vs. 14.0 ± 4.7%; all p < 0.01). In peritumoral regions, no significant difference in all ADC indices was observed between metastases and glioblastomas. The AUC values for the mean cADC (0.877) and rcADC (0.819) values in enhancing regions were significantly higher than those for ADC0Hz 5th (0.595; all p < 0.001). Conclusions The time-dependent diffusion MRI parameters may be useful for differentiating brain metastases from glioblastomas.https://doi.org/10.1186/s40644-023-00595-2DiffusionGlioblastomaMagnetic resonance imagingNeoplasm metastasis |
| spellingShingle | Kiyohisa Kamimura Yoshiki Kamimura Tsubasa Nakano Tomohito Hasegawa Masanori Nakajo Chihiro Yamada Kentaro Akune Fumitaka Ejima Takuro Ayukawa Soichiro Ito Hiroaki Nagano Koji Takumi Masatoyo Nakajo Hiroyuki Uchida Kazuhiro Tabata Takashi Iwanaga Hiroshi Imai Thorsten Feiweier Takashi Yoshiura Differentiating brain metastasis from glioblastoma by time-dependent diffusion MRI Cancer Imaging Diffusion Glioblastoma Magnetic resonance imaging Neoplasm metastasis |
| title | Differentiating brain metastasis from glioblastoma by time-dependent diffusion MRI |
| title_full | Differentiating brain metastasis from glioblastoma by time-dependent diffusion MRI |
| title_fullStr | Differentiating brain metastasis from glioblastoma by time-dependent diffusion MRI |
| title_full_unstemmed | Differentiating brain metastasis from glioblastoma by time-dependent diffusion MRI |
| title_short | Differentiating brain metastasis from glioblastoma by time-dependent diffusion MRI |
| title_sort | differentiating brain metastasis from glioblastoma by time dependent diffusion mri |
| topic | Diffusion Glioblastoma Magnetic resonance imaging Neoplasm metastasis |
| url | https://doi.org/10.1186/s40644-023-00595-2 |
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