BRCA1 deficiency in mature CD8+ T lymphocytes impairs antitumor immunity

BRCA1 deficiency in mature CD8+ T lymphocytes impairs antitumor immunity

Women with BRCA1 germline mutations have approximately an 80% lifetime chance of developing breast cancer. While the tumor suppressor function of BRCA1 in breast epithelium has been studied extensively, it is not clear whether BRCA1 deficiency in non-breast somatic cells also contribute to tumorigen...

Full description

Bibliographic Details
Main Authors:	Rong Li, Xiaowen Zhang, Bogang Wu, Yanfen Hu, Anelia Horvath, Claudine Isaacs, Yidong Chen, Leilei Qi, Huai-Chin Chiang, Haihui Pan, Alexandra Greenbaum, Elizabeth Stark, Li-Ju Wang, Bassem R. Haddad, Dionyssia Clagett, Richard Elledge
Format:	Article
Language:	English
Published:	BMJ Publishing Group 2023-02-01
Series:	Journal for ImmunoTherapy of Cancer
Online Access:	https://jitc.bmj.com/content/11/2/e005852.full

Similar Items

BRCA1, Hormone, and Tissue-Specific Tumor Suppression
by: Yanfen Hu
Published: (2009-01-01)

Phosphorylation of BRCA1 by ATM upon double-strand breaks impacts ATM function in end-resection: A potential feedback loop
by: Leilei Qi, et al.
Published: (2022-09-01)

BRCA1-Dependent Transcriptional Regulation: Implication in Tissue-Specific Tumor Suppression
by: Xiaowen Zhang, et al.
Published: (2018-12-01)

Prostate Cancer: Germline Mutations in BRCA1 and BRCA2
by: Pankaja Umarane, et al.
Published: (2023-03-01)

Comparing Prognosis for <i>BRCA1</i>, <i>BRCA2</i>, and Non-BRCA Breast Cancer
by: Pedro Antunes Meireles, et al.
Published: (2023-12-01)

COVID-19 vaccination uptake and safety profile among germline BRCA1 and BRCA2 pathogenic variant carriers in Singapore
by: Zhang, Zewen, et al.
Published: (2023)

Results of a randomized controlled trial of a decision support intervention for disclosing maternal BRCA genetic test results to children and adolescents
by: Kenneth P. Tercyak, et al.
Published: (2023-12-01)

Roles of BRCA1 and BRCA2 in DNA replication and genome stability
by: Zimmer, J
Published: (2017)

Risk assessment for hereditary breast cancer: BRCA1 and BRCA2
by: Kendra-Ann I. Seenandan-Sookdeo, et al.
Published: (2010-08-01)

Occurrence of BRCA1 and BRCA2 mutation in pancreatic cancer patients
by: A. A. Kashintsev, et al.
Published: (2016-02-01)

LOSS OF HETEROZYGOSITY IN THE BRCA1 AND BRCA2 LOCUS IN BREAST CANCER
by: M. M. Tsyganov, et al.
Published: (2020-07-01)

Screening BRCA1 and BRCA2 Mutation Carriers for Breast Cancer
by: Ellen Warner
Published: (2018-11-01)

Genetic Variation of The BRCA1 and BRCA2 Genes in Macedonian Patients
by: Plaseska-Karanfilska Dijana, et al.
Published: (2012-12-01)

Sirtuin inhibition is synthetic lethal with BRCA1 or BRCA2 deficiency
by: Ilirjana Bajrami, et al.
Published: (2021-11-01)

Diagnostic Screening Workflow for Mutations in the BRCA1 and BRCA2 Genes
by: Stella Lai, et al.
Published: (2015-01-01)

COVID-19 vaccination uptake and safety profile among germline BRCA1 and BRCA2 pathogenic variant carriers in Singapore
by: Zewen Zhang, et al.
Published: (2023-04-01)

Germline variants profiling of BRCA1 and BRCA2 in Chinese Hakka breast and ovarian cancer patients
by: Yunuo Zhang, et al.
Published: (2022-08-01)

Targeting BRCA1 and BRCA2 deficiencies with G-quadruplex-interacting compounds
by: Zimmer, J, et al.
Published: (2016)

Experience in treating BRCA-associated breast cancer. The BRCA-history of a family
by: A. V. Sultanbaev, et al.
Published: (2021-08-01)

Associations of height, body mass index, and weight gain with breast cancer risk in carriers of a pathogenic variant in BRCA1 or BRCA2: the BRCA1 and BRCA2 Cohort Consortium
by: Karin Kast, et al.
Published: (2023-06-01)

BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity.
by: Tacconi, E, et al.
Published: (2017)

BRCA1 and BRCA2 germline mutations in Chinese Hakka breast cancer patients
by: Yinmei Zhang, et al.
Published: (2024-01-01)

Different Mechanisms in Doxorubicin-Induced Cardiomyopathy: Impact of BRCA1 and BRCA2 Mutations
by: Hien C. Nguyen, et al.
Published: (2024-01-01)

Genetic epidemiology of BRCA1- and BRCA2-associated cancer across Latin America
by: Josef S. Herzog, et al.
Published: (2021-08-01)

Landscape of germline BRCA1/BRCA2 variants in breast and ovarian cancer in Peru
by: Yomali Ferreyra, et al.
Published: (2023-08-01)

Investigating the Prevalence of BRCA1 and BRCA2 Gene Mutations in Patients with Breast Cancer
by: Mohammad Hassan Tajadini, et al.
Published: (2013-02-01)

BRCA1, BRCA2 mutations — future of predictive oncology: a review of literature
by: V. N. Dmitriev, et al.
Published: (2014-07-01)

BRCA1 and BRCA2 Genetic Testing in Breast and/or Ovarian Cancer Families in Iran
by: Fatemeh Keshavarzi, et al.
Published: (2010-01-01)

Dual BRCA1 and BRCA2 pathogenic variants in an adolescent with syndromic intellectual disability
by: Arash Algouneh, et al.
Published: (2022-08-01)

Antitumor and Immunomodulatory Properties of the Bulgarian Endemic Plant <i>Betonica bulgarica</i> Degen et Neič. (Lamiaceae)
by: Tsvetelina Mladenova, et al.
Published: (2022-06-01)

Prevalence of BRCA1 and BRCA2 pathogenic variants in a large, unselected breast cancer cohort
by: Li, J, et al.
Published: (2018)

Studies in medieval physics and mathematics /
by: 409890 Clagett, Marshall
Published: (1979)

Receptivity to innovation - overcoming N.I.H.
by: Clagett, Robert Powell
Published: (2008)

The Antitumor Potential of λ-Carrageenan Oligosaccharides on Gastric Carcinoma by Immunomodulation
by: Min Tang, et al.
Published: (2023-04-01)

BRCA Mutations and Fertility Preservation
by: Joana Dias Nunes, et al.
Published: (2023-12-01)

BRCA1 and Oxidative Stress
by: Yong Weon Yi, et al.
Published: (2014-04-01)

BRCA1 testing in Lithuania
by: Janavicius Ramunas
Published: (2012-12-01)

BRCA Testing in Serbia and Montenegro
by: Brankovic-Magic Mirjana
Published: (2006-10-01)

Copy number variants as modifiers of breast cancer risk for BRCA1/BRCA2 pathogenic variant carriers
by: Christopher Hakkaart, et al.
Published: (2022-10-01)

Psychosocial impact of undergoing prostate cancer screening for men with BRCA1 or BRCA2 mutations
by: Bancroft, E, et al.
Published: (2018)