Conservative Treatment of Stage IA1 Cervical Carcinoma Without Lymphovascular Space Invasion: A 20-year Retrospective Study in Brazil
Abstract Purpose: To evaluate recurrence rates and risk factors among women with stage IA1 cervical cancer without lymph vascular space invasion managed conservatively. Methods: retrospective review of women with stage IA1 squamous cervical cancer who underwent cold knife cone or loop electrosurgi...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Federação Brasileira das Sociedades de Ginecologia e Obstetrícia
2023-06-01
|
| Series: | Revista Brasileira de Ginecologia e Obstetrícia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032023000400201&tlng=en |
| _version_ | 1797788151170727936 |
|---|---|
| author | Daniele Lima Alberton Mila Pontremoli Salcedo Raquel Potrich Zen Charles Francisco Ferreira Kathleen Schmeler Suzana Arenhart Pessini |
| author_facet | Daniele Lima Alberton Mila Pontremoli Salcedo Raquel Potrich Zen Charles Francisco Ferreira Kathleen Schmeler Suzana Arenhart Pessini |
| author_sort | Daniele Lima Alberton |
| collection | DOAJ |
| description | Abstract Purpose: To evaluate recurrence rates and risk factors among women with stage IA1 cervical cancer without lymph vascular space invasion managed conservatively. Methods: retrospective review of women with stage IA1 squamous cervical cancer who underwent cold knife cone or loop electrosurgical excision procedure, between 1994 and 2015, at a gynecologic oncology center in Southern Brazil. Age at diagnosis, pre-conization findings, conization method, margin status, residual disease, recurrence and survival rates were collected and analyzed. Results: 26 women diagnosed with stage IA1 squamous cervical cancer without lymphovascular space invasion underwent conservative management and had at least 12 months follow-up. The mean follow-up was 44.6 months. The mean age at diagnosis was 40.9 years. Median first intercourse occurred at age 16 years, 11.5% were nulliparous and 30.8% were current or past tobacco smokers. There was one Human immunodeficiency virus positive patient diagnosed with cervical intraepithelial neoplasia grade 2 at 30 months after surgery. However, there were no patients diagnosed with recurrent invasive cervical cancer and there were no deaths due to cervical cancer or other causes in the cohort. Conclusion: Excellent outcomes were noted in women with stage IA1 cervical cancer without lymphovascular space invasion and with negative margins who were managed conservatively, even in a developing country. |
| first_indexed | 2024-03-13T01:31:31Z |
| format | Article |
| id | doaj.art-eb9c2b9fb81248fcb85631bb5962b61c |
| institution | Directory Open Access Journal |
| issn | 0100-7203 |
| language | English |
| last_indexed | 2024-03-13T01:31:31Z |
| publishDate | 2023-06-01 |
| publisher | Federação Brasileira das Sociedades de Ginecologia e Obstetrícia |
| record_format | Article |
| series | Revista Brasileira de Ginecologia e Obstetrícia |
| spelling | doaj.art-eb9c2b9fb81248fcb85631bb5962b61c2023-07-04T07:41:16ZengFederação Brasileira das Sociedades de Ginecologia e ObstetríciaRevista Brasileira de Ginecologia e Obstetrícia0100-72032023-06-0145420120610.1055/s-0043-1769000Conservative Treatment of Stage IA1 Cervical Carcinoma Without Lymphovascular Space Invasion: A 20-year Retrospective Study in BrazilDaniele Lima Albertonhttps://orcid.org/0000-0002-0605-8823Mila Pontremoli Salcedohttps://orcid.org/0000-0002-6375-0736Raquel Potrich Zenhttps://orcid.org/0000-0003-3442-0823Charles Francisco Ferreirahttps://orcid.org/0000-0001-9777-7382Kathleen Schmelerhttps://orcid.org/0000-0002-9670-4189Suzana Arenhart Pessinihttps://orcid.org/0000-0003-0811-3707Abstract Purpose: To evaluate recurrence rates and risk factors among women with stage IA1 cervical cancer without lymph vascular space invasion managed conservatively. Methods: retrospective review of women with stage IA1 squamous cervical cancer who underwent cold knife cone or loop electrosurgical excision procedure, between 1994 and 2015, at a gynecologic oncology center in Southern Brazil. Age at diagnosis, pre-conization findings, conization method, margin status, residual disease, recurrence and survival rates were collected and analyzed. Results: 26 women diagnosed with stage IA1 squamous cervical cancer without lymphovascular space invasion underwent conservative management and had at least 12 months follow-up. The mean follow-up was 44.6 months. The mean age at diagnosis was 40.9 years. Median first intercourse occurred at age 16 years, 11.5% were nulliparous and 30.8% were current or past tobacco smokers. There was one Human immunodeficiency virus positive patient diagnosed with cervical intraepithelial neoplasia grade 2 at 30 months after surgery. However, there were no patients diagnosed with recurrent invasive cervical cancer and there were no deaths due to cervical cancer or other causes in the cohort. Conclusion: Excellent outcomes were noted in women with stage IA1 cervical cancer without lymphovascular space invasion and with negative margins who were managed conservatively, even in a developing country.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032023000400201&tlng=enUterine cervical neoplasmsConizationConservative treatmentRecurrenceSquamous cell carcinoma |
| spellingShingle | Daniele Lima Alberton Mila Pontremoli Salcedo Raquel Potrich Zen Charles Francisco Ferreira Kathleen Schmeler Suzana Arenhart Pessini Conservative Treatment of Stage IA1 Cervical Carcinoma Without Lymphovascular Space Invasion: A 20-year Retrospective Study in Brazil Revista Brasileira de Ginecologia e Obstetrícia Uterine cervical neoplasms Conization Conservative treatment Recurrence Squamous cell carcinoma |
| title | Conservative Treatment of Stage IA1 Cervical Carcinoma Without Lymphovascular Space Invasion: A 20-year Retrospective Study in Brazil |
| title_full | Conservative Treatment of Stage IA1 Cervical Carcinoma Without Lymphovascular Space Invasion: A 20-year Retrospective Study in Brazil |
| title_fullStr | Conservative Treatment of Stage IA1 Cervical Carcinoma Without Lymphovascular Space Invasion: A 20-year Retrospective Study in Brazil |
| title_full_unstemmed | Conservative Treatment of Stage IA1 Cervical Carcinoma Without Lymphovascular Space Invasion: A 20-year Retrospective Study in Brazil |
| title_short | Conservative Treatment of Stage IA1 Cervical Carcinoma Without Lymphovascular Space Invasion: A 20-year Retrospective Study in Brazil |
| title_sort | conservative treatment of stage ia1 cervical carcinoma without lymphovascular space invasion a 20 year retrospective study in brazil |
| topic | Uterine cervical neoplasms Conization Conservative treatment Recurrence Squamous cell carcinoma |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032023000400201&tlng=en |
| work_keys_str_mv | AT danielelimaalberton conservativetreatmentofstageia1cervicalcarcinomawithoutlymphovascularspaceinvasiona20yearretrospectivestudyinbrazil AT milapontremolisalcedo conservativetreatmentofstageia1cervicalcarcinomawithoutlymphovascularspaceinvasiona20yearretrospectivestudyinbrazil AT raquelpotrichzen conservativetreatmentofstageia1cervicalcarcinomawithoutlymphovascularspaceinvasiona20yearretrospectivestudyinbrazil AT charlesfranciscoferreira conservativetreatmentofstageia1cervicalcarcinomawithoutlymphovascularspaceinvasiona20yearretrospectivestudyinbrazil AT kathleenschmeler conservativetreatmentofstageia1cervicalcarcinomawithoutlymphovascularspaceinvasiona20yearretrospectivestudyinbrazil AT suzanaarenhartpessini conservativetreatmentofstageia1cervicalcarcinomawithoutlymphovascularspaceinvasiona20yearretrospectivestudyinbrazil |