Targeted deletion of Kcne2 causes gastritis cystica profunda and gastric neoplasia.

Targeted deletion of Kcne2 causes gastritis cystica profunda and gastric neoplasia.

Gastric cancer is the second leading cause of cancer death worldwide. Predisposing factors include achlorhydria, Helicobacter pylori infection, oxyntic atrophy and TFF2-expressing metaplasia. In parietal cells, apical potassium channels comprising the KCNQ1 alpha subunit and the KCNE2 beta subunit p...

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Bibliographic Details
Main Authors: Torsten K Roepke, Kerry Purtell, Elizabeth C King, Krista M D La Perle, Daniel J Lerner, Geoffrey W Abbott
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-07-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2897890?pdf=render

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