Affected Microcirculation and Vascular Hemodynamics in Takayasu Arteritis
Introduction: Takayasu arteritis (TAK) is a rare inflammatory disease affecting aorta and its major branches. Ultrasound (US) can detect inflammatory features in the arterial wall, but less is known regarding skin microcirculation and vascular hemodynamics. The aim was to study if assessment of thes...
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2022.926940/full |
| _version_ | 1818536688339648512 |
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| author | Christina Svensson Christina Svensson Niclas Bjarnegård Per Eriksson Hanna Jonasson Tomas Strömberg Christopher Sjöwall Helene Zachrisson Helene Zachrisson |
| author_facet | Christina Svensson Christina Svensson Niclas Bjarnegård Per Eriksson Hanna Jonasson Tomas Strömberg Christopher Sjöwall Helene Zachrisson Helene Zachrisson |
| author_sort | Christina Svensson |
| collection | DOAJ |
| description | Introduction: Takayasu arteritis (TAK) is a rare inflammatory disease affecting aorta and its major branches. Ultrasound (US) can detect inflammatory features in the arterial wall, but less is known regarding skin microcirculation and vascular hemodynamics. The aim was to study if assessment of these variables could add valuable information regarding vascular affection in TAK.Methods: 17 patients diagnosed with TAK and 17 age- and sex-matched healthy controls were included. Microcirculatory peak oxygen saturation (OxyP) in the skin after induced ischemia was evaluated with laser Doppler flowmetry/diffuse reflectance spectroscopy. Cerebrovascular reserve capacity (CVR) in the brain was assessed with transcranial Doppler (TCD). Pulse waves were recorded in the radial artery by the aid of applanation tonometry, for calculation of central augmentation index (AIx75). Intima-media thickness (IMT) and stenosis/occlusions were evaluated using US in carotid and central arteries.Results: Reduced OxyP (79 ± 8% vs. 87 ± 4%, p < 0.001) was seen in patients with TAK regardless of significant arterial stenosis/occlusion or not. Increased AIx75 (22.3 ± 13.6 vs. 9.2 ± 16.3, p = 0.01) was seen in TAK patients without significant stenosis/occlusions. No differences were found in CVR, regardless of proximal stenosis. However, signs of a more high-resistance flow profile were seen in arteria cerebri media.Conclusion: Regardless of arterial stenosis or not, impaired microcirculation of the skin and preserved CVR in the brain were found in subjects with TAK. Signs of increased arterial stiffness in the brain and central arteries were observed. The value of these findings for prediction of future cardiovascular events needs to be clarified in further studies. |
| first_indexed | 2024-12-11T18:41:10Z |
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| id | doaj.art-eb9fbe9ac23746c2a84951b5d036f94d |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-11T18:41:10Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-eb9fbe9ac23746c2a84951b5d036f94d2022-12-22T00:54:36ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2022-07-011310.3389/fphys.2022.926940926940Affected Microcirculation and Vascular Hemodynamics in Takayasu ArteritisChristina Svensson0Christina Svensson1Niclas Bjarnegård2Per Eriksson3Hanna Jonasson4Tomas Strömberg5Christopher Sjöwall6Helene Zachrisson7Helene Zachrisson8Department of Clinical Physiology, University Hospital, Linköping, SwedenDepartment of Health, Medicine and Caring Sciences, Division of Diagnostics and Specialist Medicine, Linköping University, Linköping, SwedenDepartment of Health, Medicine and Caring Sciences, Division of Diagnostics and Specialist Medicine, Linköping University, Linköping, SwedenDepartment of Biomedical and Clinical Sciences, Division of Inflammation and Infection, Linköping University, Linköping, SwedenDepartment of Biomedical Engineering, Linköping University, Linköping, SwedenDepartment of Biomedical Engineering, Linköping University, Linköping, SwedenDepartment of Biomedical and Clinical Sciences, Division of Inflammation and Infection, Linköping University, Linköping, SwedenDepartment of Clinical Physiology, University Hospital, Linköping, SwedenDepartment of Health, Medicine and Caring Sciences, Division of Diagnostics and Specialist Medicine, Linköping University, Linköping, SwedenIntroduction: Takayasu arteritis (TAK) is a rare inflammatory disease affecting aorta and its major branches. Ultrasound (US) can detect inflammatory features in the arterial wall, but less is known regarding skin microcirculation and vascular hemodynamics. The aim was to study if assessment of these variables could add valuable information regarding vascular affection in TAK.Methods: 17 patients diagnosed with TAK and 17 age- and sex-matched healthy controls were included. Microcirculatory peak oxygen saturation (OxyP) in the skin after induced ischemia was evaluated with laser Doppler flowmetry/diffuse reflectance spectroscopy. Cerebrovascular reserve capacity (CVR) in the brain was assessed with transcranial Doppler (TCD). Pulse waves were recorded in the radial artery by the aid of applanation tonometry, for calculation of central augmentation index (AIx75). Intima-media thickness (IMT) and stenosis/occlusions were evaluated using US in carotid and central arteries.Results: Reduced OxyP (79 ± 8% vs. 87 ± 4%, p < 0.001) was seen in patients with TAK regardless of significant arterial stenosis/occlusion or not. Increased AIx75 (22.3 ± 13.6 vs. 9.2 ± 16.3, p = 0.01) was seen in TAK patients without significant stenosis/occlusions. No differences were found in CVR, regardless of proximal stenosis. However, signs of a more high-resistance flow profile were seen in arteria cerebri media.Conclusion: Regardless of arterial stenosis or not, impaired microcirculation of the skin and preserved CVR in the brain were found in subjects with TAK. Signs of increased arterial stiffness in the brain and central arteries were observed. The value of these findings for prediction of future cardiovascular events needs to be clarified in further studies.https://www.frontiersin.org/articles/10.3389/fphys.2022.926940/fulltakayasu arteritismicrocirculationintima-media thicknessaugmentation indexpeak oxygen saturationbreath hold index |
| spellingShingle | Christina Svensson Christina Svensson Niclas Bjarnegård Per Eriksson Hanna Jonasson Tomas Strömberg Christopher Sjöwall Helene Zachrisson Helene Zachrisson Affected Microcirculation and Vascular Hemodynamics in Takayasu Arteritis Frontiers in Physiology takayasu arteritis microcirculation intima-media thickness augmentation index peak oxygen saturation breath hold index |
| title | Affected Microcirculation and Vascular Hemodynamics in Takayasu Arteritis |
| title_full | Affected Microcirculation and Vascular Hemodynamics in Takayasu Arteritis |
| title_fullStr | Affected Microcirculation and Vascular Hemodynamics in Takayasu Arteritis |
| title_full_unstemmed | Affected Microcirculation and Vascular Hemodynamics in Takayasu Arteritis |
| title_short | Affected Microcirculation and Vascular Hemodynamics in Takayasu Arteritis |
| title_sort | affected microcirculation and vascular hemodynamics in takayasu arteritis |
| topic | takayasu arteritis microcirculation intima-media thickness augmentation index peak oxygen saturation breath hold index |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2022.926940/full |
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