A review of malaria molecular markers for drug resistance in Plasmodium falciparum and Plasmodium vivax in China
China has now achieved the elimination of malaria, but it still faces severe challenges in the post-elimination stage. China continues to be plagued by imported malaria cases, and preventing re-transmission of imported malaria is critical. The effectiveness of antimalarial drugs for malaria control...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1167220/full |
| _version_ | 1827951627007426560 |
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| author | Siqi Wang Siqi Wang Siqi Wang Siqi Wang Fang Huang He Yan He Yan He Yan He Yan Jianhai Yin Jianhai Yin Jianhai Yin Jianhai Yin Zhigui Xia Zhigui Xia Zhigui Xia Zhigui Xia |
| author_facet | Siqi Wang Siqi Wang Siqi Wang Siqi Wang Fang Huang He Yan He Yan He Yan He Yan Jianhai Yin Jianhai Yin Jianhai Yin Jianhai Yin Zhigui Xia Zhigui Xia Zhigui Xia Zhigui Xia |
| author_sort | Siqi Wang |
| collection | DOAJ |
| description | China has now achieved the elimination of malaria, but it still faces severe challenges in the post-elimination stage. China continues to be plagued by imported malaria cases, and preventing re-transmission of imported malaria is critical. The effectiveness of antimalarial drugs for malaria control largely depends on the study of drug resistance markers in vitro. Monitoring molecular markers of parasite-associated drug resistance can help predict and manage drug resistance. There is currently a lack of systematic reviews of molecular markers for indigenous and imported malaria in China. Therefore, this review summarizes the published articles related to molecular marker polymorphism of indigenous and imported malaria cases in China in the past two decades, to study the mutation frequency and distribution of crt, mdr1, dhps, dhfr and K13 gene resistance-related loci. This can provide a whole picture of molecular markers and the resistance mutations of imported cases in China, which has certain significance for drug resistance surveillance planning, safe and effective treatment, and preventing the recurrence of local transmission by imported malaria in China in the future. |
| first_indexed | 2024-04-09T13:44:19Z |
| format | Article |
| id | doaj.art-eba66328cd254855b10f39e4d874761e |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-04-09T13:44:19Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-eba66328cd254855b10f39e4d874761e2023-05-09T05:40:42ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882023-05-011310.3389/fcimb.2023.11672201167220A review of malaria molecular markers for drug resistance in Plasmodium falciparum and Plasmodium vivax in ChinaSiqi Wang0Siqi Wang1Siqi Wang2Siqi Wang3Fang Huang4He Yan5He Yan6He Yan7He Yan8Jianhai Yin9Jianhai Yin10Jianhai Yin11Jianhai Yin12Zhigui Xia13Zhigui Xia14Zhigui Xia15Zhigui Xia16National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, ChinaNational Center for International Research on Tropical Diseases, Shanghai, ChinaNational Health Commission (NHC) Key Laboratory of Parasite and Vector Biology (National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention), Shanghai, ChinaWorld Health Organization (WHO) Collaborating Centre for Tropical Diseases, National Center for International Research on Tropical Diseases, Shanghai, ChinaShanghai Municipal Center for Disease Control and Prevention, Shanghai, ChinaNational Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, ChinaNational Center for International Research on Tropical Diseases, Shanghai, ChinaNational Health Commission (NHC) Key Laboratory of Parasite and Vector Biology (National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention), Shanghai, ChinaWorld Health Organization (WHO) Collaborating Centre for Tropical Diseases, National Center for International Research on Tropical Diseases, Shanghai, ChinaNational Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, ChinaNational Center for International Research on Tropical Diseases, Shanghai, ChinaNational Health Commission (NHC) Key Laboratory of Parasite and Vector Biology (National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention), Shanghai, ChinaWorld Health Organization (WHO) Collaborating Centre for Tropical Diseases, National Center for International Research on Tropical Diseases, Shanghai, ChinaNational Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, ChinaNational Center for International Research on Tropical Diseases, Shanghai, ChinaNational Health Commission (NHC) Key Laboratory of Parasite and Vector Biology (National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention), Shanghai, ChinaWorld Health Organization (WHO) Collaborating Centre for Tropical Diseases, National Center for International Research on Tropical Diseases, Shanghai, ChinaChina has now achieved the elimination of malaria, but it still faces severe challenges in the post-elimination stage. China continues to be plagued by imported malaria cases, and preventing re-transmission of imported malaria is critical. The effectiveness of antimalarial drugs for malaria control largely depends on the study of drug resistance markers in vitro. Monitoring molecular markers of parasite-associated drug resistance can help predict and manage drug resistance. There is currently a lack of systematic reviews of molecular markers for indigenous and imported malaria in China. Therefore, this review summarizes the published articles related to molecular marker polymorphism of indigenous and imported malaria cases in China in the past two decades, to study the mutation frequency and distribution of crt, mdr1, dhps, dhfr and K13 gene resistance-related loci. This can provide a whole picture of molecular markers and the resistance mutations of imported cases in China, which has certain significance for drug resistance surveillance planning, safe and effective treatment, and preventing the recurrence of local transmission by imported malaria in China in the future.https://www.frontiersin.org/articles/10.3389/fcimb.2023.1167220/fullPlasmodium falciparumPlasmodium vivaxpolymorphismgeneChina |
| spellingShingle | Siqi Wang Siqi Wang Siqi Wang Siqi Wang Fang Huang He Yan He Yan He Yan He Yan Jianhai Yin Jianhai Yin Jianhai Yin Jianhai Yin Zhigui Xia Zhigui Xia Zhigui Xia Zhigui Xia A review of malaria molecular markers for drug resistance in Plasmodium falciparum and Plasmodium vivax in China Frontiers in Cellular and Infection Microbiology Plasmodium falciparum Plasmodium vivax polymorphism gene China |
| title | A review of malaria molecular markers for drug resistance in Plasmodium falciparum and Plasmodium vivax in China |
| title_full | A review of malaria molecular markers for drug resistance in Plasmodium falciparum and Plasmodium vivax in China |
| title_fullStr | A review of malaria molecular markers for drug resistance in Plasmodium falciparum and Plasmodium vivax in China |
| title_full_unstemmed | A review of malaria molecular markers for drug resistance in Plasmodium falciparum and Plasmodium vivax in China |
| title_short | A review of malaria molecular markers for drug resistance in Plasmodium falciparum and Plasmodium vivax in China |
| title_sort | review of malaria molecular markers for drug resistance in plasmodium falciparum and plasmodium vivax in china |
| topic | Plasmodium falciparum Plasmodium vivax polymorphism gene China |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1167220/full |
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