Effect of hydro-alcoholic extract of Carum copticum on withdrawal syndrome in adult rats addicted to morphine
Background & Aim: Long-term useofopioidcreates toleranceandphysical and psychologicaldependence. Discontinuation of the drug, creating ashortageofendogenousopioidsandwithdrawal syndromeemerges.Addictiontreatmentin traditional medicine isusing ofherbssuch asCarumcopticumthathas manytherapeutic ef...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | fas |
| Published: |
Yasuj University Of Medical Sciences
2016-02-01
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| Series: | Armaghane Danesh Bimonthly Journal |
| Subjects: | |
| Online Access: | http://armaghanj.yums.ac.ir/browse.php?a_code=A-10-344-1&slc_lang=en&sid=1 |
| _version_ | 1818018300005711872 |
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| author | A honarvar H delaviz M Jafari Barmak A Roozbehi |
| author_facet | A honarvar H delaviz M Jafari Barmak A Roozbehi |
| author_sort | A honarvar |
| collection | DOAJ |
| description | Background & Aim: Long-term useofopioidcreates toleranceandphysical and psychologicaldependence. Discontinuation of the drug, creating ashortageofendogenousopioidsandwithdrawal syndromeemerges.Addictiontreatmentin traditional medicine isusing ofherbssuch asCarumcopticumthathas manytherapeutic effects. The purpose of thisstudy was to evaluatethe effects of hydro-alcoholic extractof Carumcopticum onwithdrawalsyndromein adult ratsaddictedto morphine.
Material & Method: In this study70male Wistarratsdividedinto seven groups of 10, six groups were addicted by morphinesulfateinjection (the first 5days10 mg/kg, the second 5days15 mg/kg andon the dayfrom11 to21, 20mg/kg) subcutaneouslyfor 21 days.Groups three, four and five were fed respectively 10%, 20% Carumcopticum extract and methadone (mg/kg 5) after addiction of animals until the end of period. Groups sixandseven were given respectively10%and 20% of Carumcopticumextractfrom the beginning to the end of treatment period orally.Group one(control) andGrouptwo (morphine) were fed daily 0.5 mL of saline orally to the end of the treatment period (day 21to 35).Datacollected from body weight, jumping, itchingand diarrhea ofanimals wereanalyzedby SPSS software, using Unpaired T test, ANOVA and LSD as post-hoc statistical tests.
Finding: Comparing the mean of weight loose ofthe animals in different treatmentgroupson day21with 35showed statistical significant reduction in the group that received extract of Carumcopticum 10%. On the day 21,itchingand jumping, in the group that received extract of Carumcopticum 10%,and the diarrhea, in the group that receivedthe extract ofCarumcopticum20%compared withthe control groupshoweda significant decrease(P<0.05).On day35,Jumping and diarrheain thegroupsreceived theextract ofCarumcopticum10 and 20percent comparedwith the control groupshoweda significant decrease(P<0.05).
Conclusion: According to the results, hydro-alcoholic extract of carumcopticum inconcentration of 10and 20percent are effectivein reducingwithdrawal syndromeofmorphine as like as methadone.Perhapsitcan be usedas an alternative tomethadoneinaddictiontoreducepainfulwithdrawalsyndromeand freed from the side effects ofmethadone.This suggestionneeds a widerinvestigation. |
| first_indexed | 2024-04-14T07:37:13Z |
| format | Article |
| id | doaj.art-eba718b56db14dc2a34b5f7eb4fd2d52 |
| institution | Directory Open Access Journal |
| issn | 1728-6506 1728-6514 |
| language | fas |
| last_indexed | 2024-04-14T07:37:13Z |
| publishDate | 2016-02-01 |
| publisher | Yasuj University Of Medical Sciences |
| record_format | Article |
| series | Armaghane Danesh Bimonthly Journal |
| spelling | doaj.art-eba718b56db14dc2a34b5f7eb4fd2d522022-12-22T02:05:39ZfasYasuj University Of Medical SciencesArmaghane Danesh Bimonthly Journal1728-65061728-65142016-02-0120119961010Effect of hydro-alcoholic extract of Carum copticum on withdrawal syndrome in adult rats addicted to morphineA honarvar0H delaviz1M Jafari Barmak2A Roozbehi3 Yasuj Univesity of MedicalSciences Yasuj Univesity of MedicalSciences Yasuj Univesity of MedicalSciences Yasuj Univesity of MedicalSciences Background & Aim: Long-term useofopioidcreates toleranceandphysical and psychologicaldependence. Discontinuation of the drug, creating ashortageofendogenousopioidsandwithdrawal syndromeemerges.Addictiontreatmentin traditional medicine isusing ofherbssuch asCarumcopticumthathas manytherapeutic effects. The purpose of thisstudy was to evaluatethe effects of hydro-alcoholic extractof Carumcopticum onwithdrawalsyndromein adult ratsaddictedto morphine. Material & Method: In this study70male Wistarratsdividedinto seven groups of 10, six groups were addicted by morphinesulfateinjection (the first 5days10 mg/kg, the second 5days15 mg/kg andon the dayfrom11 to21, 20mg/kg) subcutaneouslyfor 21 days.Groups three, four and five were fed respectively 10%, 20% Carumcopticum extract and methadone (mg/kg 5) after addiction of animals until the end of period. Groups sixandseven were given respectively10%and 20% of Carumcopticumextractfrom the beginning to the end of treatment period orally.Group one(control) andGrouptwo (morphine) were fed daily 0.5 mL of saline orally to the end of the treatment period (day 21to 35).Datacollected from body weight, jumping, itchingand diarrhea ofanimals wereanalyzedby SPSS software, using Unpaired T test, ANOVA and LSD as post-hoc statistical tests. Finding: Comparing the mean of weight loose ofthe animals in different treatmentgroupson day21with 35showed statistical significant reduction in the group that received extract of Carumcopticum 10%. On the day 21,itchingand jumping, in the group that received extract of Carumcopticum 10%,and the diarrhea, in the group that receivedthe extract ofCarumcopticum20%compared withthe control groupshoweda significant decrease(P<0.05).On day35,Jumping and diarrheain thegroupsreceived theextract ofCarumcopticum10 and 20percent comparedwith the control groupshoweda significant decrease(P<0.05). Conclusion: According to the results, hydro-alcoholic extract of carumcopticum inconcentration of 10and 20percent are effectivein reducingwithdrawal syndromeofmorphine as like as methadone.Perhapsitcan be usedas an alternative tomethadoneinaddictiontoreducepainfulwithdrawalsyndromeand freed from the side effects ofmethadone.This suggestionneeds a widerinvestigation.http://armaghanj.yums.ac.ir/browse.php?a_code=A-10-344-1&slc_lang=en&sid=1Withdrawal syndrome Carum copticum morphine methadone Addiction |
| spellingShingle | A honarvar H delaviz M Jafari Barmak A Roozbehi Effect of hydro-alcoholic extract of Carum copticum on withdrawal syndrome in adult rats addicted to morphine Armaghane Danesh Bimonthly Journal Withdrawal syndrome Carum copticum morphine methadone Addiction |
| title | Effect of hydro-alcoholic extract of Carum copticum on withdrawal syndrome in adult rats addicted to morphine |
| title_full | Effect of hydro-alcoholic extract of Carum copticum on withdrawal syndrome in adult rats addicted to morphine |
| title_fullStr | Effect of hydro-alcoholic extract of Carum copticum on withdrawal syndrome in adult rats addicted to morphine |
| title_full_unstemmed | Effect of hydro-alcoholic extract of Carum copticum on withdrawal syndrome in adult rats addicted to morphine |
| title_short | Effect of hydro-alcoholic extract of Carum copticum on withdrawal syndrome in adult rats addicted to morphine |
| title_sort | effect of hydro alcoholic extract of carum copticum on withdrawal syndrome in adult rats addicted to morphine |
| topic | Withdrawal syndrome Carum copticum morphine methadone Addiction |
| url | http://armaghanj.yums.ac.ir/browse.php?a_code=A-10-344-1&slc_lang=en&sid=1 |
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