Dermatological toxicity of EGFR inhibitors: pathogenetic rationale and an algorithm for acne-like rash correction
Therapy with epidermal growth factor receptor (EGFR) inhibitors is inevitably accompanied by the phenomena of dermatological toxicity. Being, on the one hand, a favorable prognostic factor for the effectiveness of anticancer therapy, these adverse events are one of the most frequent indications for...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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ABV-press
2021-11-01
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| Series: | Онкогематология |
| Subjects: | |
| Online Access: | https://oncohematology.abvpress.ru/ongm/article/view/504 |
| _version_ | 1797855508626931712 |
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| author | A. V. Michenko L. S. Kruglova E. A. Shatokhina I. B. Kononenko A. S. Polonskaya D. V. Romanov |
| author_facet | A. V. Michenko L. S. Kruglova E. A. Shatokhina I. B. Kononenko A. S. Polonskaya D. V. Romanov |
| author_sort | A. V. Michenko |
| collection | DOAJ |
| description | Therapy with epidermal growth factor receptor (EGFR) inhibitors is inevitably accompanied by the phenomena of dermatological toxicity. Being, on the one hand, a favorable prognostic factor for the effectiveness of anticancer therapy, these adverse events are one of the most frequent indications for treatment withdrawal. This article presents the clinical characteristics of a wide spectrum of dermatological adverse events, as well as the pathogenetic rationale for their correction. Algorithms for prescribing of external and systemic therapy based on the assessment of severity of skin lesions and skin appendages involvement are presented. |
| first_indexed | 2024-04-09T20:24:49Z |
| format | Article |
| id | doaj.art-eba763607e334152b166c66c5c8a1320 |
| institution | Directory Open Access Journal |
| issn | 1818-8346 2413-4023 |
| language | Russian |
| last_indexed | 2024-04-09T20:24:49Z |
| publishDate | 2021-11-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Онкогематология |
| spelling | doaj.art-eba763607e334152b166c66c5c8a13202023-03-30T20:15:13ZrusABV-pressОнкогематология1818-83462413-40232021-11-0116410.17650/1818-8346-2021-16-4-50-58411Dermatological toxicity of EGFR inhibitors: pathogenetic rationale and an algorithm for acne-like rash correctionA. V. Michenko0L. S. Kruglova1E. A. Shatokhina2I. B. Kononenko3A. S. Polonskaya4D. V. Romanov5Central State Medical Academy, Administrative Directorate of the President of the Russian FederationCentral State Medical Academy, Administrative Directorate of the President of the Russian FederationCentral State Medical Academy, Administrative Directorate of the President of the Russian FederationN.A. Lopatkin Research Institute of Urology and Interventional Radiology – branch of the National Medical Research Radiological Center, Ministry of Health of RussiaCentral State Medical Academy, Administrative Directorate of the President of the Russian FederationI.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University); Mental Health Research CenterTherapy with epidermal growth factor receptor (EGFR) inhibitors is inevitably accompanied by the phenomena of dermatological toxicity. Being, on the one hand, a favorable prognostic factor for the effectiveness of anticancer therapy, these adverse events are one of the most frequent indications for treatment withdrawal. This article presents the clinical characteristics of a wide spectrum of dermatological adverse events, as well as the pathogenetic rationale for their correction. Algorithms for prescribing of external and systemic therapy based on the assessment of severity of skin lesions and skin appendages involvement are presented.https://oncohematology.abvpress.ru/ongm/article/view/504skin toxicityepidermal growth factor inhibitoracne-like rash |
| spellingShingle | A. V. Michenko L. S. Kruglova E. A. Shatokhina I. B. Kononenko A. S. Polonskaya D. V. Romanov Dermatological toxicity of EGFR inhibitors: pathogenetic rationale and an algorithm for acne-like rash correction Онкогематология skin toxicity epidermal growth factor inhibitor acne-like rash |
| title | Dermatological toxicity of EGFR inhibitors: pathogenetic rationale and an algorithm for acne-like rash correction |
| title_full | Dermatological toxicity of EGFR inhibitors: pathogenetic rationale and an algorithm for acne-like rash correction |
| title_fullStr | Dermatological toxicity of EGFR inhibitors: pathogenetic rationale and an algorithm for acne-like rash correction |
| title_full_unstemmed | Dermatological toxicity of EGFR inhibitors: pathogenetic rationale and an algorithm for acne-like rash correction |
| title_short | Dermatological toxicity of EGFR inhibitors: pathogenetic rationale and an algorithm for acne-like rash correction |
| title_sort | dermatological toxicity of egfr inhibitors pathogenetic rationale and an algorithm for acne like rash correction |
| topic | skin toxicity epidermal growth factor inhibitor acne-like rash |
| url | https://oncohematology.abvpress.ru/ongm/article/view/504 |
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