Inhibition of pannexin‐1 does not restore electrolyte balance in precystic Pkd1 knockout mice

Inhibition of pannexin‐1 does not restore electrolyte balance in precystic Pkd1 knockout mice

Abstract Mutations in PKD1 and PKD2 cause autosomal dominant polycystic kidney disease (ADPKD), which is characterized by the formation of fluid‐filled cysts in the kidney. In a subset of ADPKD patients, reduced blood calcium (Ca2+) and magnesium (Mg2+) concentrations are observed. As cystic fluid c...

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Bibliographic Details
Main Authors: Wouter H. vanMegen, Teun J. vanHoutert, Caro Bos, Dorien J. M. Peters, Jeroen H. F. deBaaij, Joost G. J. Hoenderop
Format: Article
Language:English
Published: Wiley 2024-04-01
Series:Physiological Reports
Subjects:
ADPKD
calcium
kidney
magnesium
pannexin‐1
Online Access:https://doi.org/10.14814/phy2.15956

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