Expressions and Roles of Periostin in Otolaryngological Diseases
Periostin is a 90-kDa member of the fasciclin-containing family; it functions as part of matricellular proteins, and its production by airway epithelial cells is induced by IL-4 and IL-13. Periostin is secreted by fibroblasts and upregulated in the airway epithelia of patients with bronchial asthma;...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2014-01-01
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| Series: | Allergology International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1323893015300290 |
| _version_ | 1818140995124985856 |
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| author | Nobuo Ohta Akihiro Ishida Kazuya Kurakami Yusuke Suzuki Seiji Kakehata Junya Ono Hiroki Ikeda Kimihiro Okubo Kenji Izuhara |
| author_facet | Nobuo Ohta Akihiro Ishida Kazuya Kurakami Yusuke Suzuki Seiji Kakehata Junya Ono Hiroki Ikeda Kimihiro Okubo Kenji Izuhara |
| author_sort | Nobuo Ohta |
| collection | DOAJ |
| description | Periostin is a 90-kDa member of the fasciclin-containing family; it functions as part of matricellular proteins, and its production by airway epithelial cells is induced by IL-4 and IL-13. Periostin is secreted by fibroblasts and upregulated in the airway epithelia of patients with bronchial asthma; it is considered to contribute to remodeling under this pathological condition. However, despite many studies in diverse research areas, our overall understanding of this intriguing molecule is still inadequate. Here, we integrate the available evidence on periostin expression and its roles in otolaryngological diseases, including allergic rhinitis, chronic rhinosinusitis with nasal polyps, aspirin-induced asthma, organized hematoma, eosinophilic otitis media, and IgG4-related disease. Periostin might be involved as an important structural mediator in pathological processes such as insult and injury, Th2-driven inflammation, extracellular matrix restructuring, fibrosclerosis, tumor angiogenesis, and tissue remodeling. |
| first_indexed | 2024-12-11T10:52:50Z |
| format | Article |
| id | doaj.art-eba83adccfe64bd39e1d8fa5fd0d04f9 |
| institution | Directory Open Access Journal |
| issn | 1323-8930 |
| language | English |
| last_indexed | 2024-12-11T10:52:50Z |
| publishDate | 2014-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Allergology International |
| spelling | doaj.art-eba83adccfe64bd39e1d8fa5fd0d04f92022-12-22T01:10:14ZengElsevierAllergology International1323-89302014-01-0163217118010.2332/allergolint.13-RAI-0673Expressions and Roles of Periostin in Otolaryngological DiseasesNobuo Ohta0Akihiro Ishida1Kazuya Kurakami2Yusuke Suzuki3Seiji Kakehata4Junya Ono5Hiroki Ikeda6Kimihiro Okubo7Kenji Izuhara8Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, Yamagata University, YamagataDepartment of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, Yamagata University, YamagataDepartment of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, Yamagata University, YamagataDepartment of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, Yamagata University, YamagataDepartment of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, Yamagata University, YamagataShino-Test Corporation,KanagawaDepartment of Otolaryngology, Japanese Red Cross Society, Wakayama Medical Center, WakayamaDepartment of Otolaryngology, Nippon Medical School, TokyoDivision of Medical Biochemistry, Department of Biomolecular Sciences, Faculty of Medicine, Saga Medical School, Saga, Japan.Periostin is a 90-kDa member of the fasciclin-containing family; it functions as part of matricellular proteins, and its production by airway epithelial cells is induced by IL-4 and IL-13. Periostin is secreted by fibroblasts and upregulated in the airway epithelia of patients with bronchial asthma; it is considered to contribute to remodeling under this pathological condition. However, despite many studies in diverse research areas, our overall understanding of this intriguing molecule is still inadequate. Here, we integrate the available evidence on periostin expression and its roles in otolaryngological diseases, including allergic rhinitis, chronic rhinosinusitis with nasal polyps, aspirin-induced asthma, organized hematoma, eosinophilic otitis media, and IgG4-related disease. Periostin might be involved as an important structural mediator in pathological processes such as insult and injury, Th2-driven inflammation, extracellular matrix restructuring, fibrosclerosis, tumor angiogenesis, and tissue remodeling.http://www.sciencedirect.com/science/article/pii/S1323893015300290allergic rhinitisaspirin-induced asthmachronic rhinosinusitis with nasal polypsIgG4-related diseaseperiostin |
| spellingShingle | Nobuo Ohta Akihiro Ishida Kazuya Kurakami Yusuke Suzuki Seiji Kakehata Junya Ono Hiroki Ikeda Kimihiro Okubo Kenji Izuhara Expressions and Roles of Periostin in Otolaryngological Diseases Allergology International allergic rhinitis aspirin-induced asthma chronic rhinosinusitis with nasal polyps IgG4-related disease periostin |
| title | Expressions and Roles of Periostin in Otolaryngological Diseases |
| title_full | Expressions and Roles of Periostin in Otolaryngological Diseases |
| title_fullStr | Expressions and Roles of Periostin in Otolaryngological Diseases |
| title_full_unstemmed | Expressions and Roles of Periostin in Otolaryngological Diseases |
| title_short | Expressions and Roles of Periostin in Otolaryngological Diseases |
| title_sort | expressions and roles of periostin in otolaryngological diseases |
| topic | allergic rhinitis aspirin-induced asthma chronic rhinosinusitis with nasal polyps IgG4-related disease periostin |
| url | http://www.sciencedirect.com/science/article/pii/S1323893015300290 |
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