Atypical and severe manifestations of chikungunya virus infection in French Guiana: A hospital-based study.
<h4>Background</h4>French Guiana (FG) was the first country in South America to declare chikungunya virus infection (CHIKV). The outbreak affected about 16,000 persons between February 2014 and October 2015, with several atypical cases, but only two fatal cases. We aimed to describe the...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0207406 |
| _version_ | 1819115084709888000 |
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| author | Timothee Bonifay Christelle Prince Clarisse Neyra Magalie Demar Dominique Rousset Hatem Kallel Mathieu Nacher Félix Djossou Loïc Epelboin Char Chik Working group |
| author_facet | Timothee Bonifay Christelle Prince Clarisse Neyra Magalie Demar Dominique Rousset Hatem Kallel Mathieu Nacher Félix Djossou Loïc Epelboin Char Chik Working group |
| author_sort | Timothee Bonifay |
| collection | DOAJ |
| description | <h4>Background</h4>French Guiana (FG) was the first country in South America to declare chikungunya virus infection (CHIKV). The outbreak affected about 16,000 persons between February 2014 and October 2015, with several atypical cases, but only two fatal cases. We aimed to describe the clinical presentation of patients hospitalized for CHIKV infection, to estimate and identify risk factors of unusual and severe forms in adult patients.<h4>Materials and methods</h4>A monocentric retrospective study was conducted in Cayenne hospital, the main city and the main hospital in FG, from March 1st 2014 to August 31st 2015. All patients admitted for at least one night with a biological diagnosis of CHIKV infection during the 2014/2015 outbreak were included, except pregnant women and children under 15 years.<h4>Results</h4>During the study period, 285 patients with a diagnosis of CHIKV infection were hospitalized in Cayenne hospital, among whom 96 nonpregnant adults were studied. Five were classified as severe forms (5.2%) and 23 as unusual forms (23.9%). The most frequent atypical and/or severe form was neurological (n = 20), followed by cardio-respiratory failure (acute respiratory failure n = 4, acute heart failure n = 2), digestive and hepatic disorders (acute hepatitis n = 3, acute pancreatitis n = 2), renal disorders (acute renal failure n = 5) and muscular impairment (rhabdomyolysis n = 3).<h4>Conclusion</h4>During the outbreak, hospitalizations were frequent, particularly for common forms, driven by algic clinical presentations and concerns due to the novelty of this infection. Despite atypical neurological and liver forms of CHIKV infection, case-fatality was low in French Guiana. No specific risk factor of atypical and/or severe forms was found in our study. |
| first_indexed | 2024-12-22T04:55:34Z |
| format | Article |
| id | doaj.art-eba90e6298684afba13afc6ca244b081 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T04:55:34Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-eba90e6298684afba13afc6ca244b0812022-12-21T18:38:23ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-011312e020740610.1371/journal.pone.0207406Atypical and severe manifestations of chikungunya virus infection in French Guiana: A hospital-based study.Timothee BonifayChristelle PrinceClarisse NeyraMagalie DemarDominique RoussetHatem KallelMathieu NacherFélix DjossouLoïc EpelboinChar Chik Working group<h4>Background</h4>French Guiana (FG) was the first country in South America to declare chikungunya virus infection (CHIKV). The outbreak affected about 16,000 persons between February 2014 and October 2015, with several atypical cases, but only two fatal cases. We aimed to describe the clinical presentation of patients hospitalized for CHIKV infection, to estimate and identify risk factors of unusual and severe forms in adult patients.<h4>Materials and methods</h4>A monocentric retrospective study was conducted in Cayenne hospital, the main city and the main hospital in FG, from March 1st 2014 to August 31st 2015. All patients admitted for at least one night with a biological diagnosis of CHIKV infection during the 2014/2015 outbreak were included, except pregnant women and children under 15 years.<h4>Results</h4>During the study period, 285 patients with a diagnosis of CHIKV infection were hospitalized in Cayenne hospital, among whom 96 nonpregnant adults were studied. Five were classified as severe forms (5.2%) and 23 as unusual forms (23.9%). The most frequent atypical and/or severe form was neurological (n = 20), followed by cardio-respiratory failure (acute respiratory failure n = 4, acute heart failure n = 2), digestive and hepatic disorders (acute hepatitis n = 3, acute pancreatitis n = 2), renal disorders (acute renal failure n = 5) and muscular impairment (rhabdomyolysis n = 3).<h4>Conclusion</h4>During the outbreak, hospitalizations were frequent, particularly for common forms, driven by algic clinical presentations and concerns due to the novelty of this infection. Despite atypical neurological and liver forms of CHIKV infection, case-fatality was low in French Guiana. No specific risk factor of atypical and/or severe forms was found in our study.https://doi.org/10.1371/journal.pone.0207406 |
| spellingShingle | Timothee Bonifay Christelle Prince Clarisse Neyra Magalie Demar Dominique Rousset Hatem Kallel Mathieu Nacher Félix Djossou Loïc Epelboin Char Chik Working group Atypical and severe manifestations of chikungunya virus infection in French Guiana: A hospital-based study. PLoS ONE |
| title | Atypical and severe manifestations of chikungunya virus infection in French Guiana: A hospital-based study. |
| title_full | Atypical and severe manifestations of chikungunya virus infection in French Guiana: A hospital-based study. |
| title_fullStr | Atypical and severe manifestations of chikungunya virus infection in French Guiana: A hospital-based study. |
| title_full_unstemmed | Atypical and severe manifestations of chikungunya virus infection in French Guiana: A hospital-based study. |
| title_short | Atypical and severe manifestations of chikungunya virus infection in French Guiana: A hospital-based study. |
| title_sort | atypical and severe manifestations of chikungunya virus infection in french guiana a hospital based study |
| url | https://doi.org/10.1371/journal.pone.0207406 |
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