Distribution of TAS2R38 bitter taste receptor phenotype and haplotypes among COVID-19 patients
Abstract Bitter taste receptor TAS2R38 is expressed in the respiratory tract and can respond to quorum-sensing molecules produced by pathogens, stimulating the release of nitric oxide, with biocidal activity. TAS2R38 presents two main high-frequency haplotypes: the “taster” PAV and the “non-taster”...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-10747-2 |
| _version_ | 1811308226410446848 |
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| author | D. Risso D. Carmagnola G. Morini G. Pellegrini E. Canciani M. Antinucci D. Henin C. Dellavia |
| author_facet | D. Risso D. Carmagnola G. Morini G. Pellegrini E. Canciani M. Antinucci D. Henin C. Dellavia |
| author_sort | D. Risso |
| collection | DOAJ |
| description | Abstract Bitter taste receptor TAS2R38 is expressed in the respiratory tract and can respond to quorum-sensing molecules produced by pathogens, stimulating the release of nitric oxide, with biocidal activity. TAS2R38 presents two main high-frequency haplotypes: the “taster” PAV and the “non-taster” AVI. Individuals carrying the AVI allele could be at greater risk of infections, including SARS-CoV-2. The aim of this study was to assess the frequency of PAV and AVI alleles in COVID-19 patients with severe or non-severe symptoms compared to healthy subjects to further corroborate, or not, the hypothesis that the PAV allele may act as a protecting factor towards SARS-CoV-2 infection while the AVI one may represent a risk factor. After careful selection, 54 individuals were included in the study and underwent genetic analysis and PROP phenotype assessment. Our investigation could not point out at a significant relationship between single nucleotide polymorphisms responsible for PROP bitterness and presence/severity of SARS-CoV-2 infection, as previous studies suggested. Our results uncouple the direct genetic contribution of rs10246939, rs1726866 and rs713598 on COVID-19, calling for caution when proposing a treatment based on TAS2R38 phenotypes. |
| first_indexed | 2024-04-13T09:19:24Z |
| format | Article |
| id | doaj.art-ebafc68eb8db4492897e7bb00889fca3 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-13T09:19:24Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-ebafc68eb8db4492897e7bb00889fca32022-12-22T02:52:40ZengNature PortfolioScientific Reports2045-23222022-05-011211710.1038/s41598-022-10747-2Distribution of TAS2R38 bitter taste receptor phenotype and haplotypes among COVID-19 patientsD. Risso0D. Carmagnola1G. Morini2G. Pellegrini3E. Canciani4M. Antinucci5D. Henin6C. Dellavia7Tate & Lyle PLCDepartment of Biomedical, Surgical and Dental Sciences, Università degli Studi di MilanoUniversity of Gastronomic ScienceasDepartment of Biomedical, Surgical and Dental Sciences, Università degli Studi di MilanoDepartment of Biomedical, Surgical and Dental Sciences, Università degli Studi di MilanoDepartment of Medicine and Life Sciences, Institute of Evolutionary Biology (UPF-CSIC), Universitat Pompeu FabraDepartment of Biomedical, Surgical and Dental Sciences, Università degli Studi di MilanoDepartment of Biomedical, Surgical and Dental Sciences, Università degli Studi di MilanoAbstract Bitter taste receptor TAS2R38 is expressed in the respiratory tract and can respond to quorum-sensing molecules produced by pathogens, stimulating the release of nitric oxide, with biocidal activity. TAS2R38 presents two main high-frequency haplotypes: the “taster” PAV and the “non-taster” AVI. Individuals carrying the AVI allele could be at greater risk of infections, including SARS-CoV-2. The aim of this study was to assess the frequency of PAV and AVI alleles in COVID-19 patients with severe or non-severe symptoms compared to healthy subjects to further corroborate, or not, the hypothesis that the PAV allele may act as a protecting factor towards SARS-CoV-2 infection while the AVI one may represent a risk factor. After careful selection, 54 individuals were included in the study and underwent genetic analysis and PROP phenotype assessment. Our investigation could not point out at a significant relationship between single nucleotide polymorphisms responsible for PROP bitterness and presence/severity of SARS-CoV-2 infection, as previous studies suggested. Our results uncouple the direct genetic contribution of rs10246939, rs1726866 and rs713598 on COVID-19, calling for caution when proposing a treatment based on TAS2R38 phenotypes.https://doi.org/10.1038/s41598-022-10747-2 |
| spellingShingle | D. Risso D. Carmagnola G. Morini G. Pellegrini E. Canciani M. Antinucci D. Henin C. Dellavia Distribution of TAS2R38 bitter taste receptor phenotype and haplotypes among COVID-19 patients Scientific Reports |
| title | Distribution of TAS2R38 bitter taste receptor phenotype and haplotypes among COVID-19 patients |
| title_full | Distribution of TAS2R38 bitter taste receptor phenotype and haplotypes among COVID-19 patients |
| title_fullStr | Distribution of TAS2R38 bitter taste receptor phenotype and haplotypes among COVID-19 patients |
| title_full_unstemmed | Distribution of TAS2R38 bitter taste receptor phenotype and haplotypes among COVID-19 patients |
| title_short | Distribution of TAS2R38 bitter taste receptor phenotype and haplotypes among COVID-19 patients |
| title_sort | distribution of tas2r38 bitter taste receptor phenotype and haplotypes among covid 19 patients |
| url | https://doi.org/10.1038/s41598-022-10747-2 |
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