The Role of the Cerebellum in Drug Reward: A Review
Drug abuse remains a global problem; nonetheless, its mechanism has not yet been fully understood. Recent studies have reported on the non-motor functions of the cerebellum, and evidence from neuroimaging and behavioral studies has suggested the role of cerebellum in drug reward, which has received...
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| Format: | Article |
| Language: | English |
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IMR Press
2023-10-01
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| Series: | Journal of Integrative Neuroscience |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/JIN/22/6/10.31083/j.jin2206147 |
| _version_ | 1827390622919557120 |
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| author | Yong-bo Wang Yan Lan |
| author_facet | Yong-bo Wang Yan Lan |
| author_sort | Yong-bo Wang |
| collection | DOAJ |
| description | Drug abuse remains a global problem; nonetheless, its mechanism has not yet been fully understood. Recent studies have reported on the non-motor functions of the cerebellum, and evidence from neuroimaging and behavioral studies has suggested the role of cerebellum in drug reward, which has received increasing attention. Furthermore, emerging technological developments have aided in clarifying the various circuits and functions of the cerebellum. Exploring the role of the cerebellum in drug reward can improve our understanding of the mechanism underlying addiction and facilitate the development of new treatment schemes. This review summarizes the anatomy of the cerebellum and its connections to brain regions considered important in addiction. Subsequently, we investigate the neurological reasons elucidating why the cerebellum is a potential target for drug reward. Additionally, we expound the molecular targets of addictive drugs in the cerebellum, mainly glutamate and endocannabinoids. Unlike previous studies, this article focuses on the influence of alcohol, nicotine, morphine, cannabis, and cocaine on the cerebellum from multiple viewpoints, including imaging and behavioral changes, molecular signals, neurotransmitters, and synaptic transmission. We aim to clarify some drug-induced cerebellar changes to supplement the previous research regarding the relationship between addiction and the cerebellum. Finally, we discuss the limitations and prospects of drug reward research on the cerebellum to provide novel insights into studying the cerebellum and its role in addiction. We recommend that future addiction network models should include the cerebellum to provide new therapeutic targets for treating addiction. |
| first_indexed | 2024-03-08T16:55:26Z |
| format | Article |
| id | doaj.art-ebb0779c6d924dada46bd4a50b11a09b |
| institution | Directory Open Access Journal |
| issn | 0219-6352 |
| language | English |
| last_indexed | 2024-03-08T16:55:26Z |
| publishDate | 2023-10-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Journal of Integrative Neuroscience |
| spelling | doaj.art-ebb0779c6d924dada46bd4a50b11a09b2024-01-05T02:39:08ZengIMR PressJournal of Integrative Neuroscience0219-63522023-10-0122614710.31083/j.jin2206147S0219-6352(23)00619-8The Role of the Cerebellum in Drug Reward: A ReviewYong-bo Wang0Yan Lan1Department of Physiology and Pathophysiology, College of Medicine, Yanbian University, 133002 Yanji, Jilin, ChinaDepartment of Physiology and Pathophysiology, College of Medicine, Yanbian University, 133002 Yanji, Jilin, ChinaDrug abuse remains a global problem; nonetheless, its mechanism has not yet been fully understood. Recent studies have reported on the non-motor functions of the cerebellum, and evidence from neuroimaging and behavioral studies has suggested the role of cerebellum in drug reward, which has received increasing attention. Furthermore, emerging technological developments have aided in clarifying the various circuits and functions of the cerebellum. Exploring the role of the cerebellum in drug reward can improve our understanding of the mechanism underlying addiction and facilitate the development of new treatment schemes. This review summarizes the anatomy of the cerebellum and its connections to brain regions considered important in addiction. Subsequently, we investigate the neurological reasons elucidating why the cerebellum is a potential target for drug reward. Additionally, we expound the molecular targets of addictive drugs in the cerebellum, mainly glutamate and endocannabinoids. Unlike previous studies, this article focuses on the influence of alcohol, nicotine, morphine, cannabis, and cocaine on the cerebellum from multiple viewpoints, including imaging and behavioral changes, molecular signals, neurotransmitters, and synaptic transmission. We aim to clarify some drug-induced cerebellar changes to supplement the previous research regarding the relationship between addiction and the cerebellum. Finally, we discuss the limitations and prospects of drug reward research on the cerebellum to provide novel insights into studying the cerebellum and its role in addiction. We recommend that future addiction network models should include the cerebellum to provide new therapeutic targets for treating addiction.https://www.imrpress.com/journal/JIN/22/6/10.31083/j.jin2206147cerebellumdrug rewardmorphinealcoholnicotinecannabiscocaineaddiction |
| spellingShingle | Yong-bo Wang Yan Lan The Role of the Cerebellum in Drug Reward: A Review Journal of Integrative Neuroscience cerebellum drug reward morphine alcohol nicotine cannabis cocaine addiction |
| title | The Role of the Cerebellum in Drug Reward: A Review |
| title_full | The Role of the Cerebellum in Drug Reward: A Review |
| title_fullStr | The Role of the Cerebellum in Drug Reward: A Review |
| title_full_unstemmed | The Role of the Cerebellum in Drug Reward: A Review |
| title_short | The Role of the Cerebellum in Drug Reward: A Review |
| title_sort | role of the cerebellum in drug reward a review |
| topic | cerebellum drug reward morphine alcohol nicotine cannabis cocaine addiction |
| url | https://www.imrpress.com/journal/JIN/22/6/10.31083/j.jin2206147 |
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