Ciliary Neurotrophic Factor (CNTF) affects the excitable and contractile properties of innervated skeletal muscles
The well-established trophic role of CNTF upon neurons led to performing clinical trials in patients of neurodegenerative diseases. However, trials were suspended due to side effects such as severe weight loss, hyperalgesia, coughing, muscle cramps and pain. So far it is not known how CNTF triggers...
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| Format: | Article |
| Language: | English |
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BMC
2003-01-01
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| Series: | Biological Research |
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| Online Access: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602003000300003 |
| _version_ | 1828845524002799616 |
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| author | BEATRIZ U RAMIREZ LEIRA RETAMAL CECILIA VERGARA |
| author_facet | BEATRIZ U RAMIREZ LEIRA RETAMAL CECILIA VERGARA |
| author_sort | BEATRIZ U RAMIREZ |
| collection | DOAJ |
| description | The well-established trophic role of CNTF upon neurons led to performing clinical trials in patients of neurodegenerative diseases. However, trials were suspended due to side effects such as severe weight loss, hyperalgesia, coughing, muscle cramps and pain. So far it is not known how CNTF triggers the problems related to skeletal muscle cramps and pain. CNTF has also been described as a myotrophic factor for denervated skeletal muscles, but the possibility that it affects innervated muscles has also been considered. Since a myotrophic factor could be a valuable tool for treatment of several muscle diseases, we studied the effects of low doses of CNTF delivered systemically by an osmotic pump, over the electrical and mechanical properties of innervated and denervated fast and slow muscles. CNTF induced spontaneous electrical discharges and slowed twitches in innervated muscles, but did not prevent the changes induced by denervation. We postulate that the spontaneous discharges induced by CNTF in innervated muscles may be the cause of the cramps, coughing, and muscle ache reported by patients. At low doses, CNTF does not exert its myotrophic role over denervated muscles but clearly affects the excitable and contractile properties of innervated muscles. |
| first_indexed | 2024-12-12T21:30:03Z |
| format | Article |
| id | doaj.art-ebb0c7fa3dfb4f02a4a12b8c7602c5a2 |
| institution | Directory Open Access Journal |
| issn | 0716-9760 0717-6287 |
| language | English |
| last_indexed | 2024-12-12T21:30:03Z |
| publishDate | 2003-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Biological Research |
| spelling | doaj.art-ebb0c7fa3dfb4f02a4a12b8c7602c5a22022-12-22T00:11:21ZengBMCBiological Research0716-97600717-62872003-01-01363-4303312Ciliary Neurotrophic Factor (CNTF) affects the excitable and contractile properties of innervated skeletal musclesBEATRIZ U RAMIREZLEIRA RETAMALCECILIA VERGARAThe well-established trophic role of CNTF upon neurons led to performing clinical trials in patients of neurodegenerative diseases. However, trials were suspended due to side effects such as severe weight loss, hyperalgesia, coughing, muscle cramps and pain. So far it is not known how CNTF triggers the problems related to skeletal muscle cramps and pain. CNTF has also been described as a myotrophic factor for denervated skeletal muscles, but the possibility that it affects innervated muscles has also been considered. Since a myotrophic factor could be a valuable tool for treatment of several muscle diseases, we studied the effects of low doses of CNTF delivered systemically by an osmotic pump, over the electrical and mechanical properties of innervated and denervated fast and slow muscles. CNTF induced spontaneous electrical discharges and slowed twitches in innervated muscles, but did not prevent the changes induced by denervation. We postulate that the spontaneous discharges induced by CNTF in innervated muscles may be the cause of the cramps, coughing, and muscle ache reported by patients. At low doses, CNTF does not exert its myotrophic role over denervated muscles but clearly affects the excitable and contractile properties of innervated muscles.http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602003000300003CNTFcontraction and relaxation timedenervationEMGfibrillationskeletal muscle |
| spellingShingle | BEATRIZ U RAMIREZ LEIRA RETAMAL CECILIA VERGARA Ciliary Neurotrophic Factor (CNTF) affects the excitable and contractile properties of innervated skeletal muscles Biological Research CNTF contraction and relaxation time denervation EMG fibrillation skeletal muscle |
| title | Ciliary Neurotrophic Factor (CNTF) affects the excitable and contractile properties of innervated skeletal muscles |
| title_full | Ciliary Neurotrophic Factor (CNTF) affects the excitable and contractile properties of innervated skeletal muscles |
| title_fullStr | Ciliary Neurotrophic Factor (CNTF) affects the excitable and contractile properties of innervated skeletal muscles |
| title_full_unstemmed | Ciliary Neurotrophic Factor (CNTF) affects the excitable and contractile properties of innervated skeletal muscles |
| title_short | Ciliary Neurotrophic Factor (CNTF) affects the excitable and contractile properties of innervated skeletal muscles |
| title_sort | ciliary neurotrophic factor cntf affects the excitable and contractile properties of innervated skeletal muscles |
| topic | CNTF contraction and relaxation time denervation EMG fibrillation skeletal muscle |
| url | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602003000300003 |
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