Hearing loss and brain disorders: A review of multiple pathologies
Several causative factors are associated with hearing loss (HL) and brain disorders. However, there are many unidentified disease modifiers in these conditions. Our study summarised the most common brain disorders associated with HL and highlighted mechanisms of pathologies. We searched the literatu...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2021-12-01
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| Series: | Open Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/med-2021-0402 |
| _version_ | 1811252848946577408 |
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| author | Oluwole Oluwafemi Gabriel James Kili Yalcouye Abdoulaye Wonkam Ambroise |
| author_facet | Oluwole Oluwafemi Gabriel James Kili Yalcouye Abdoulaye Wonkam Ambroise |
| author_sort | Oluwole Oluwafemi Gabriel |
| collection | DOAJ |
| description | Several causative factors are associated with hearing loss (HL) and brain disorders. However, there are many unidentified disease modifiers in these conditions. Our study summarised the most common brain disorders associated with HL and highlighted mechanisms of pathologies. We searched the literature for published articles on HL and brain disorders. Alzheimer’s disease/dementia, Parkinson’s disease, cognitive impairment, autism spectrum disorder, ataxia, epilepsy, stroke, and hypoxic-ischaemic encephalopathy majorly co-interact with HL. The estimated incidence rate was 113 per 10,000 person-years. Genetic, epigenetic, early life/neonatal stress, hypoxia, inflammation, nitric oxide infiltration, endoplasmic reticulum stress, and excess glutamate were the distinguished modifiers identified. Various mechanisms like adhesion molecules, transport proteins, hair cell apoptosis, and neurodegeneration have been implicated in these conditions and are serving as potential targets for therapies. To improve the quality of life of patients, these understandings will improve clinical diagnoses and management of HL and brain disorders. |
| first_indexed | 2024-04-12T16:40:52Z |
| format | Article |
| id | doaj.art-ebb1a61822134533a697756d748e43fb |
| institution | Directory Open Access Journal |
| issn | 2391-5463 |
| language | English |
| last_indexed | 2024-04-12T16:40:52Z |
| publishDate | 2021-12-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Medicine |
| spelling | doaj.art-ebb1a61822134533a697756d748e43fb2022-12-22T03:24:48ZengDe GruyterOpen Medicine2391-54632021-12-01171616910.1515/med-2021-0402Hearing loss and brain disorders: A review of multiple pathologiesOluwole Oluwafemi Gabriel0James Kili1Yalcouye Abdoulaye2Wonkam Ambroise3Division of Human Genetics, Faculty of Health Sciences, University of Cape Town, 3.14 Wernher & Beit North Building, P.O Box 7925, Cape Town, South AfricaDivision of Human Genetics, Faculty of Health Sciences, University of Cape Town, 3.14 Wernher & Beit North Building, P.O Box 7925, Cape Town, South AfricaDivision of Human Genetics, Faculty of Health Sciences, University of Cape Town, 3.14 Wernher & Beit North Building, P.O Box 7925, Cape Town, South AfricaDivision of Human Genetics, Faculty of Health Sciences, University of Cape Town, 3.14 Wernher & Beit North Building, P.O Box 7925, Cape Town, South AfricaSeveral causative factors are associated with hearing loss (HL) and brain disorders. However, there are many unidentified disease modifiers in these conditions. Our study summarised the most common brain disorders associated with HL and highlighted mechanisms of pathologies. We searched the literature for published articles on HL and brain disorders. Alzheimer’s disease/dementia, Parkinson’s disease, cognitive impairment, autism spectrum disorder, ataxia, epilepsy, stroke, and hypoxic-ischaemic encephalopathy majorly co-interact with HL. The estimated incidence rate was 113 per 10,000 person-years. Genetic, epigenetic, early life/neonatal stress, hypoxia, inflammation, nitric oxide infiltration, endoplasmic reticulum stress, and excess glutamate were the distinguished modifiers identified. Various mechanisms like adhesion molecules, transport proteins, hair cell apoptosis, and neurodegeneration have been implicated in these conditions and are serving as potential targets for therapies. To improve the quality of life of patients, these understandings will improve clinical diagnoses and management of HL and brain disorders.https://doi.org/10.1515/med-2021-0402hearing lossbrain disorderspathologycorrelated risk factors |
| spellingShingle | Oluwole Oluwafemi Gabriel James Kili Yalcouye Abdoulaye Wonkam Ambroise Hearing loss and brain disorders: A review of multiple pathologies Open Medicine hearing loss brain disorders pathology correlated risk factors |
| title | Hearing loss and brain disorders: A review of multiple pathologies |
| title_full | Hearing loss and brain disorders: A review of multiple pathologies |
| title_fullStr | Hearing loss and brain disorders: A review of multiple pathologies |
| title_full_unstemmed | Hearing loss and brain disorders: A review of multiple pathologies |
| title_short | Hearing loss and brain disorders: A review of multiple pathologies |
| title_sort | hearing loss and brain disorders a review of multiple pathologies |
| topic | hearing loss brain disorders pathology correlated risk factors |
| url | https://doi.org/10.1515/med-2021-0402 |
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