Cardiac magnetic resonance assessment of aortic distensibility in prediabetic patients
Abstract Background Hyperglycemia, insulin resistance, and hyperinsulinemia represent important pathophysiological components of the prediabetic stage that result in arteriosclerosis and increased arterial stiffness. We sought to compare the aortic distensibility (AD) assessed by cardiac magnetic re...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2020-01-01
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| Series: | The Egyptian Heart Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43044-020-0040-0 |
| _version_ | 1818961563169587200 |
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| author | Nady A. Razik Y. T. Kishk Madeeha Younis Bakheet Mina Nous Mohamed Abdel Ghany |
| author_facet | Nady A. Razik Y. T. Kishk Madeeha Younis Bakheet Mina Nous Mohamed Abdel Ghany |
| author_sort | Nady A. Razik |
| collection | DOAJ |
| description | Abstract Background Hyperglycemia, insulin resistance, and hyperinsulinemia represent important pathophysiological components of the prediabetic stage that result in arteriosclerosis and increased arterial stiffness. We sought to compare the aortic distensibility (AD) assessed by cardiac magnetic resonance (CMR) in prediabetic patients presenting with chronic coronary artery disease (CCAD) versus patients with normal HbA1C. Ninety-eight patients with CCAD were recruited. All patients were screened for HbA1C levels and then underwent a CMR study to assess AD of the aortic root and the ascending and descending thoracic aorta. Patients were classified into two groups: 52 prediabetic (HbA1C 5.7–6.4%) (study group) and 46 with normal glycemic status (HbA1C < 5.7%) (control group). Results AD values at the aortic root (AR) (13.93 ± 5.17 vs 34.3 ± 9.65 Kpa-1 × 10-3), ascending aorta (AA) (13.17 ± 4.81 vs 28.1 ± 8.33 Kpa-1 × 10-3), and descending thoracic aorta (DA) (18.12 ± 4.34 vs 33.68 ± 7.57 Kpa-1 × 10-3) were significantly lower in the study group than in the control group (P value for all was < 0.001). Twenty-eight patients fulfilled the criteria for metabolic syndrome, and in those patients, AD was significantly lower than in those without metabolic syndrome. Aortic distensibility at the AR, AA, and DA had strong significant negative correlations with the level of glycosylated hemoglobin (AA, AR, DA; r − 0.66, − 0.68, − 0.58, respectively) (P < 0.001). Conclusion AD values at different points (AR, AA, and DA) were significantly lower in prediabetic and metabolic syndrome patients than in controls. These values also showed a significant negative correlation with the levels of HBA1C. |
| first_indexed | 2024-12-20T12:15:25Z |
| format | Article |
| id | doaj.art-ebb29d1e1e734fb185a435a42563449e |
| institution | Directory Open Access Journal |
| issn | 2090-911X |
| language | English |
| last_indexed | 2024-12-20T12:15:25Z |
| publishDate | 2020-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Heart Journal |
| spelling | doaj.art-ebb29d1e1e734fb185a435a42563449e2022-12-21T19:41:10ZengSpringerOpenThe Egyptian Heart Journal2090-911X2020-01-017211710.1186/s43044-020-0040-0Cardiac magnetic resonance assessment of aortic distensibility in prediabetic patientsNady A. Razik0Y. T. Kishk1Madeeha Younis Bakheet2Mina Nous3Mohamed Abdel Ghany4Assiut UniversityAssiut UniversityAssiut UniversityAssiut UniversityAssiut UniversityAbstract Background Hyperglycemia, insulin resistance, and hyperinsulinemia represent important pathophysiological components of the prediabetic stage that result in arteriosclerosis and increased arterial stiffness. We sought to compare the aortic distensibility (AD) assessed by cardiac magnetic resonance (CMR) in prediabetic patients presenting with chronic coronary artery disease (CCAD) versus patients with normal HbA1C. Ninety-eight patients with CCAD were recruited. All patients were screened for HbA1C levels and then underwent a CMR study to assess AD of the aortic root and the ascending and descending thoracic aorta. Patients were classified into two groups: 52 prediabetic (HbA1C 5.7–6.4%) (study group) and 46 with normal glycemic status (HbA1C < 5.7%) (control group). Results AD values at the aortic root (AR) (13.93 ± 5.17 vs 34.3 ± 9.65 Kpa-1 × 10-3), ascending aorta (AA) (13.17 ± 4.81 vs 28.1 ± 8.33 Kpa-1 × 10-3), and descending thoracic aorta (DA) (18.12 ± 4.34 vs 33.68 ± 7.57 Kpa-1 × 10-3) were significantly lower in the study group than in the control group (P value for all was < 0.001). Twenty-eight patients fulfilled the criteria for metabolic syndrome, and in those patients, AD was significantly lower than in those without metabolic syndrome. Aortic distensibility at the AR, AA, and DA had strong significant negative correlations with the level of glycosylated hemoglobin (AA, AR, DA; r − 0.66, − 0.68, − 0.58, respectively) (P < 0.001). Conclusion AD values at different points (AR, AA, and DA) were significantly lower in prediabetic and metabolic syndrome patients than in controls. These values also showed a significant negative correlation with the levels of HBA1C.https://doi.org/10.1186/s43044-020-0040-0Aortic distensibilityPrediabetesMetabolic syndromeCMRCAD |
| spellingShingle | Nady A. Razik Y. T. Kishk Madeeha Younis Bakheet Mina Nous Mohamed Abdel Ghany Cardiac magnetic resonance assessment of aortic distensibility in prediabetic patients The Egyptian Heart Journal Aortic distensibility Prediabetes Metabolic syndrome CMR CAD |
| title | Cardiac magnetic resonance assessment of aortic distensibility in prediabetic patients |
| title_full | Cardiac magnetic resonance assessment of aortic distensibility in prediabetic patients |
| title_fullStr | Cardiac magnetic resonance assessment of aortic distensibility in prediabetic patients |
| title_full_unstemmed | Cardiac magnetic resonance assessment of aortic distensibility in prediabetic patients |
| title_short | Cardiac magnetic resonance assessment of aortic distensibility in prediabetic patients |
| title_sort | cardiac magnetic resonance assessment of aortic distensibility in prediabetic patients |
| topic | Aortic distensibility Prediabetes Metabolic syndrome CMR CAD |
| url | https://doi.org/10.1186/s43044-020-0040-0 |
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