Coopted temporal patterning governs cellular hierarchy, heterogeneity and metabolism in Drosophila neuroblast tumors

Coopted temporal patterning governs cellular hierarchy, heterogeneity and metabolism in Drosophila neuroblast tumors

It is still unclear what drives progression of childhood tumors. During Drosophila larval development, asymmetrically-dividing neural stem cells, called neuroblasts, progress through an intrinsic temporal patterning program that ensures cessation of divisions before adulthood. We previously showed t...

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Bibliographic Details
Main Authors: Sara Genovese, Raphaël Clément, Cassandra Gaultier, Florence Besse, Karine Narbonne-Reveau, Fabrice Daian, Sophie Foppolo, Nuno Miguel Luis, Cédric Maurange
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-09-01
Series:eLife
Subjects:
pediatric cancer
cancer stem cell
temporal patterning
Imp
syncrip
tumor hierarchy
Online Access:https://elifesciences.org/articles/50375

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