Sulfur signaling pathway in cardiovascular disease
Hydrogen sulfide (H2S) and sulfur dioxide (SO2), recognized as endogenous sulfur-containing gas signaling molecules, were the third and fourth molecules to be identified subsequent to nitric oxide and carbon monoxide (CO), and exerted diverse biological effects on the cardiovascular system. However,...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1303465/full |
| _version_ | 1797463651582476288 |
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| author | Yunjia Song Zihang Xu Qing Zhong Rong Zhang Xutao Sun Guozhen Chen |
| author_facet | Yunjia Song Zihang Xu Qing Zhong Rong Zhang Xutao Sun Guozhen Chen |
| author_sort | Yunjia Song |
| collection | DOAJ |
| description | Hydrogen sulfide (H2S) and sulfur dioxide (SO2), recognized as endogenous sulfur-containing gas signaling molecules, were the third and fourth molecules to be identified subsequent to nitric oxide and carbon monoxide (CO), and exerted diverse biological effects on the cardiovascular system. However, the exact mechanisms underlying the actions of H2S and SO2 have remained elusive until now. Recently, novel post-translational modifications known as S-sulfhydration and S-sulfenylation, induced by H2S and SO2 respectively, have been proposed. These modifications involve the chemical alteration of specific cysteine residues in target proteins through S-sulfhydration and S-sulfenylation, respectively. H2S induced S-sulfhydrylation can have a significant impact on various cellular processes such as cell survival, apoptosis, cell proliferation, metabolism, mitochondrial function, endoplasmic reticulum stress, vasodilation, anti-inflammatory response and oxidative stress in the cardiovascular system. Alternatively, S-sulfenylation caused by SO2 serves primarily to maintain vascular homeostasis. Additional research is warranted to explore the physiological function of proteins with specific cysteine sites, despite the considerable advancements in comprehending the role of H2S-induced S-sulfhydration and SO2-induced S-sulfenylation in the cardiovascular system. The primary objective of this review is to present a comprehensive examination of the function and potential mechanism of S-sulfhydration and S-sulfenylation in the cardiovascular system. Proteins that undergo S-sulfhydration and S-sulfenylation may serve as promising targets for therapeutic intervention and drug development in the cardiovascular system. This could potentially expedite the future development and utilization of drugs related to H2S and SO2. |
| first_indexed | 2024-03-09T17:53:47Z |
| format | Article |
| id | doaj.art-ebb3d5f3656d45fa8b3ee407e610a6e4 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-09T17:53:47Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-ebb3d5f3656d45fa8b3ee407e610a6e42023-11-24T10:32:41ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-11-011410.3389/fphar.2023.13034651303465Sulfur signaling pathway in cardiovascular diseaseYunjia Song0Zihang Xu1Qing Zhong2Rong Zhang3Xutao Sun4Guozhen Chen5Department of Pharmacology, School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, Harbin, ChinaDepartment of Pharmacology, School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, Harbin, ChinaDepartment of Pharmacology, School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, Harbin, ChinaDepartment of Pharmacology, School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, Harbin, ChinaDepartment of Typhoid, School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, Harbin, ChinaDepartment of Pediatrics, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, ChinaHydrogen sulfide (H2S) and sulfur dioxide (SO2), recognized as endogenous sulfur-containing gas signaling molecules, were the third and fourth molecules to be identified subsequent to nitric oxide and carbon monoxide (CO), and exerted diverse biological effects on the cardiovascular system. However, the exact mechanisms underlying the actions of H2S and SO2 have remained elusive until now. Recently, novel post-translational modifications known as S-sulfhydration and S-sulfenylation, induced by H2S and SO2 respectively, have been proposed. These modifications involve the chemical alteration of specific cysteine residues in target proteins through S-sulfhydration and S-sulfenylation, respectively. H2S induced S-sulfhydrylation can have a significant impact on various cellular processes such as cell survival, apoptosis, cell proliferation, metabolism, mitochondrial function, endoplasmic reticulum stress, vasodilation, anti-inflammatory response and oxidative stress in the cardiovascular system. Alternatively, S-sulfenylation caused by SO2 serves primarily to maintain vascular homeostasis. Additional research is warranted to explore the physiological function of proteins with specific cysteine sites, despite the considerable advancements in comprehending the role of H2S-induced S-sulfhydration and SO2-induced S-sulfenylation in the cardiovascular system. The primary objective of this review is to present a comprehensive examination of the function and potential mechanism of S-sulfhydration and S-sulfenylation in the cardiovascular system. Proteins that undergo S-sulfhydration and S-sulfenylation may serve as promising targets for therapeutic intervention and drug development in the cardiovascular system. This could potentially expedite the future development and utilization of drugs related to H2S and SO2.https://www.frontiersin.org/articles/10.3389/fphar.2023.1303465/fullH2SSO2S-sulfhydrationS-sulfenylationcardiovascular disease |
| spellingShingle | Yunjia Song Zihang Xu Qing Zhong Rong Zhang Xutao Sun Guozhen Chen Sulfur signaling pathway in cardiovascular disease Frontiers in Pharmacology H2S SO2 S-sulfhydration S-sulfenylation cardiovascular disease |
| title | Sulfur signaling pathway in cardiovascular disease |
| title_full | Sulfur signaling pathway in cardiovascular disease |
| title_fullStr | Sulfur signaling pathway in cardiovascular disease |
| title_full_unstemmed | Sulfur signaling pathway in cardiovascular disease |
| title_short | Sulfur signaling pathway in cardiovascular disease |
| title_sort | sulfur signaling pathway in cardiovascular disease |
| topic | H2S SO2 S-sulfhydration S-sulfenylation cardiovascular disease |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1303465/full |
| work_keys_str_mv | AT yunjiasong sulfursignalingpathwayincardiovasculardisease AT zihangxu sulfursignalingpathwayincardiovasculardisease AT qingzhong sulfursignalingpathwayincardiovasculardisease AT rongzhang sulfursignalingpathwayincardiovasculardisease AT xutaosun sulfursignalingpathwayincardiovasculardisease AT guozhenchen sulfursignalingpathwayincardiovasculardisease |