A RETROSPECTIVE STUDY ON MULTI DRUG RESISTANT TUBERCULOSIS IN A TERTIARY CARE HOSPITAL: AN ALARMING THREAT OF CONCERN.
Introduction: MDR-TB is becoming a significant global health concern in this era. Globally, the incidence of MDR-TB is 3.4% in new cases and 18% in previously treated cases. MDR-TB mostly arises due to inadequate treatment, poor compliance to drugs, and/or direct contact with an MDR-TB patient a...
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| Format: | Article |
| Language: | English |
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Student's Journal of Health Research
2023-06-01
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| Series: | Student's Journal of Health Research Africa |
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| Online Access: | https://sjhresearchafrica.org/index.php/public-html/article/view/484 |
| _version_ | 1797791347099303936 |
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| author | Kumari Seema Abhay Kumar Manju Boipai Dr. Ashok Kumar Sharma Manoj Kumar |
| author_facet | Kumari Seema Abhay Kumar Manju Boipai Dr. Ashok Kumar Sharma Manoj Kumar |
| author_sort | Kumari Seema |
| collection | DOAJ |
| description |
Introduction:
MDR-TB is becoming a significant global health concern in this era. Globally, the incidence of MDR-TB is 3.4% in new cases and 18% in previously treated cases. MDR-TB mostly arises due to inadequate treatment, poor compliance to drugs, and/or direct contact with an MDR-TB patient and hence is essentially a man-made phenomenon. The prevalence of MDR-TB in any area is mirrored by the functional state and efficiency of tuberculosis control programs running in the country.
Material and Method:
A total of 549 cases were recruited during the period from 2017 to 2019 and the data were analysed retrospectively. Both pulmonary and extra-pulmonary samples were collected with proper aseptic measures. Direct microscopy by Ziehl Neelsen (ZN) staining was done. Further liquid culture and first-line drug susceptibility testing were performed in MGIT 960.
Result:
Out of 549 enrolled cases, 312 Mycobacterium tuberculosis cases were confirmed. The prevalence of mono or multi-drug resistance of MTB patients to 1st line drugs during 2017, 2018, and 2019 were 51.7%, 52.1%, and 49.1% respectively. The present study showed a prevalence of MDR-TB in new cases and of previously treated TB cases on an average of 2.7% and 11.2% which is slightly lower than the national level data of 3.4% and 18% respectively.
Conclusion:
India is showing an increased prevalence of MDR-TB which leads to the greatest obstacle to the End TB strategy adopted by WHO and the government of India. There is an urgent need for continuous surveillance of MDR-TB.
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| first_indexed | 2024-03-13T02:17:28Z |
| format | Article |
| id | doaj.art-ebb4d37d357b4b8e8d18d48baa6b924c |
| institution | Directory Open Access Journal |
| issn | 2709-9997 |
| language | English |
| last_indexed | 2024-03-13T02:17:28Z |
| publishDate | 2023-06-01 |
| publisher | Student's Journal of Health Research |
| record_format | Article |
| series | Student's Journal of Health Research Africa |
| spelling | doaj.art-ebb4d37d357b4b8e8d18d48baa6b924c2023-06-30T11:43:21ZengStudent's Journal of Health ResearchStudent's Journal of Health Research Africa2709-99972023-06-014610.51168/sjhrafrica.v4i6.484A RETROSPECTIVE STUDY ON MULTI DRUG RESISTANT TUBERCULOSIS IN A TERTIARY CARE HOSPITAL: AN ALARMING THREAT OF CONCERN.Kumari Seema0Abhay Kumar1Manju Boipai2Dr. Ashok Kumar Sharma3Manoj Kumar4Department of Microbiology, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India, Pin Code – 834009.Department of Microbiology, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India, Pin Code – 834009.Department of Microbiology, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India, Pin Code – 834009.Department of Microbiology, Rajendra Institute of Medical Sciences, Ranchi, JharkhandDepartment of Microbiology, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India, Pin Code – 834009. Introduction: MDR-TB is becoming a significant global health concern in this era. Globally, the incidence of MDR-TB is 3.4% in new cases and 18% in previously treated cases. MDR-TB mostly arises due to inadequate treatment, poor compliance to drugs, and/or direct contact with an MDR-TB patient and hence is essentially a man-made phenomenon. The prevalence of MDR-TB in any area is mirrored by the functional state and efficiency of tuberculosis control programs running in the country. Material and Method: A total of 549 cases were recruited during the period from 2017 to 2019 and the data were analysed retrospectively. Both pulmonary and extra-pulmonary samples were collected with proper aseptic measures. Direct microscopy by Ziehl Neelsen (ZN) staining was done. Further liquid culture and first-line drug susceptibility testing were performed in MGIT 960. Result: Out of 549 enrolled cases, 312 Mycobacterium tuberculosis cases were confirmed. The prevalence of mono or multi-drug resistance of MTB patients to 1st line drugs during 2017, 2018, and 2019 were 51.7%, 52.1%, and 49.1% respectively. The present study showed a prevalence of MDR-TB in new cases and of previously treated TB cases on an average of 2.7% and 11.2% which is slightly lower than the national level data of 3.4% and 18% respectively. Conclusion: India is showing an increased prevalence of MDR-TB which leads to the greatest obstacle to the End TB strategy adopted by WHO and the government of India. There is an urgent need for continuous surveillance of MDR-TB. https://sjhresearchafrica.org/index.php/public-html/article/view/484PulmonaryMDR-TBprevalenceresistanceMGIT 960 |
| spellingShingle | Kumari Seema Abhay Kumar Manju Boipai Dr. Ashok Kumar Sharma Manoj Kumar A RETROSPECTIVE STUDY ON MULTI DRUG RESISTANT TUBERCULOSIS IN A TERTIARY CARE HOSPITAL: AN ALARMING THREAT OF CONCERN. Student's Journal of Health Research Africa Pulmonary MDR-TB prevalence resistance MGIT 960 |
| title | A RETROSPECTIVE STUDY ON MULTI DRUG RESISTANT TUBERCULOSIS IN A TERTIARY CARE HOSPITAL: AN ALARMING THREAT OF CONCERN. |
| title_full | A RETROSPECTIVE STUDY ON MULTI DRUG RESISTANT TUBERCULOSIS IN A TERTIARY CARE HOSPITAL: AN ALARMING THREAT OF CONCERN. |
| title_fullStr | A RETROSPECTIVE STUDY ON MULTI DRUG RESISTANT TUBERCULOSIS IN A TERTIARY CARE HOSPITAL: AN ALARMING THREAT OF CONCERN. |
| title_full_unstemmed | A RETROSPECTIVE STUDY ON MULTI DRUG RESISTANT TUBERCULOSIS IN A TERTIARY CARE HOSPITAL: AN ALARMING THREAT OF CONCERN. |
| title_short | A RETROSPECTIVE STUDY ON MULTI DRUG RESISTANT TUBERCULOSIS IN A TERTIARY CARE HOSPITAL: AN ALARMING THREAT OF CONCERN. |
| title_sort | retrospective study on multi drug resistant tuberculosis in a tertiary care hospital an alarming threat of concern |
| topic | Pulmonary MDR-TB prevalence resistance MGIT 960 |
| url | https://sjhresearchafrica.org/index.php/public-html/article/view/484 |
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