Endocrine Fertility Parameters—Genomic Background and Their Genetic Relationship to Boar Taint in German Landrace and Large White
The surgical castration of young male piglets without anesthesia is no longer allowed in Germany from 2021. One alternative is breeding against boar taint, but shared synthesis pathways of androstenone (AND) and several endocrine fertility parameters (EFP) indicate a risk of decreasing fertility. Th...
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MDPI AG
2021-01-01
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| author | Ines Brinke Christine Große-Brinkhaus Katharina Roth Maren Julia Pröll-Cornelissen Sebastian Klein Karl Schellander Ernst Tholen |
| author_facet | Ines Brinke Christine Große-Brinkhaus Katharina Roth Maren Julia Pröll-Cornelissen Sebastian Klein Karl Schellander Ernst Tholen |
| author_sort | Ines Brinke |
| collection | DOAJ |
| description | The surgical castration of young male piglets without anesthesia is no longer allowed in Germany from 2021. One alternative is breeding against boar taint, but shared synthesis pathways of androstenone (AND) and several endocrine fertility parameters (EFP) indicate a risk of decreasing fertility. The objective of this study was to investigate the genetic background between AND, skatole (SKA), and six EFP in purebred Landrace (LR) and Large White (LW) populations. The animals were clustered according to their genetic relatedness because of their different origins. Estimated heritabilities (h<sup>2</sup>) of AND and SKA ranged between 0.52 and 0.34 in LR and LW. For EFP, h<sup>2</sup> differed between the breeds except for follicle-stimulating hormone (FSH) (h<sup>2</sup>: 0.28–0.37). Both of the breeds showed unfavorable relationships between AND and testosterone, 17-β estradiol, and FSH. The genetic relationships (r<sub>g</sub>) between SKA and EFP differed between the breeds. A genome-wide association analysis revealed 48 significant associations and confirmed a region for SKA on <i>Sus Scrofa</i> chromosome (SSC) 14. For EFP, the results differed between the clusters. In conclusion, r<sub>g</sub> partly confirmed physiologically expected antagonisms between AND and EFP. Particular attention should be spent on fertility traits that are based on EFP when breeding against boar taint to balance the genetic progress in both of the trait complexes. |
| first_indexed | 2024-03-09T04:24:23Z |
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| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-09T04:24:23Z |
| publishDate | 2021-01-01 |
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| series | Animals |
| spelling | doaj.art-ebb79aacfb1848c0932f12cb232df6502023-12-03T13:43:07ZengMDPI AGAnimals2076-26152021-01-0111123110.3390/ani11010231Endocrine Fertility Parameters—Genomic Background and Their Genetic Relationship to Boar Taint in German Landrace and Large WhiteInes Brinke0Christine Große-Brinkhaus1Katharina Roth2Maren Julia Pröll-Cornelissen3Sebastian Klein4Karl Schellander5Ernst Tholen6Institute of Animal Science, University of Bonn, 53115 Bonn, GermanyInstitute of Animal Science, University of Bonn, 53115 Bonn, GermanyInstitute of Animal Science, University of Bonn, 53115 Bonn, GermanyInstitute of Animal Science, University of Bonn, 53115 Bonn, GermanyAssociation for Bioeconomy Research (FBF e.V.), Adenauerallee 174, 53113 Bonn, GermanyInstitute of Animal Science, University of Bonn, 53115 Bonn, GermanyInstitute of Animal Science, University of Bonn, 53115 Bonn, GermanyThe surgical castration of young male piglets without anesthesia is no longer allowed in Germany from 2021. One alternative is breeding against boar taint, but shared synthesis pathways of androstenone (AND) and several endocrine fertility parameters (EFP) indicate a risk of decreasing fertility. The objective of this study was to investigate the genetic background between AND, skatole (SKA), and six EFP in purebred Landrace (LR) and Large White (LW) populations. The animals were clustered according to their genetic relatedness because of their different origins. Estimated heritabilities (h<sup>2</sup>) of AND and SKA ranged between 0.52 and 0.34 in LR and LW. For EFP, h<sup>2</sup> differed between the breeds except for follicle-stimulating hormone (FSH) (h<sup>2</sup>: 0.28–0.37). Both of the breeds showed unfavorable relationships between AND and testosterone, 17-β estradiol, and FSH. The genetic relationships (r<sub>g</sub>) between SKA and EFP differed between the breeds. A genome-wide association analysis revealed 48 significant associations and confirmed a region for SKA on <i>Sus Scrofa</i> chromosome (SSC) 14. For EFP, the results differed between the clusters. In conclusion, r<sub>g</sub> partly confirmed physiologically expected antagonisms between AND and EFP. Particular attention should be spent on fertility traits that are based on EFP when breeding against boar taint to balance the genetic progress in both of the trait complexes.https://www.mdpi.com/2076-2615/11/1/231boar taintfertilityhormonespigsandrostenoneskatole |
| spellingShingle | Ines Brinke Christine Große-Brinkhaus Katharina Roth Maren Julia Pröll-Cornelissen Sebastian Klein Karl Schellander Ernst Tholen Endocrine Fertility Parameters—Genomic Background and Their Genetic Relationship to Boar Taint in German Landrace and Large White Animals boar taint fertility hormones pigs androstenone skatole |
| title | Endocrine Fertility Parameters—Genomic Background and Their Genetic Relationship to Boar Taint in German Landrace and Large White |
| title_full | Endocrine Fertility Parameters—Genomic Background and Their Genetic Relationship to Boar Taint in German Landrace and Large White |
| title_fullStr | Endocrine Fertility Parameters—Genomic Background and Their Genetic Relationship to Boar Taint in German Landrace and Large White |
| title_full_unstemmed | Endocrine Fertility Parameters—Genomic Background and Their Genetic Relationship to Boar Taint in German Landrace and Large White |
| title_short | Endocrine Fertility Parameters—Genomic Background and Their Genetic Relationship to Boar Taint in German Landrace and Large White |
| title_sort | endocrine fertility parameters genomic background and their genetic relationship to boar taint in german landrace and large white |
| topic | boar taint fertility hormones pigs androstenone skatole |
| url | https://www.mdpi.com/2076-2615/11/1/231 |
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