Influence of nandrolone decanoate administration on serum lipids and liver enzymes in rats
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| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Vesnu Publications
2015-07-01
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| Series: | ARYA Atherosclerosis |
| Subjects: | |
| Online Access: | http://arya.mui.ac.ir/index.php/arya/article/view/879 |
| _version_ | 1818521720912347136 |
|---|---|
| author | Mohammad Reza Samieinasab Mohammad Reza Shahraki Fatemah Samieinasab Somayeh Najafi |
| author_facet | Mohammad Reza Samieinasab Mohammad Reza Shahraki Fatemah Samieinasab Somayeh Najafi |
| author_sort | Mohammad Reza Samieinasab |
| collection | DOAJ |
| description | <!--[if gte mso 9]><xml> <w:WordDocument> <w:View>Normal</w:View> <w:Zoom>0</w:Zoom> <w:TrackMoves /> <w:TrackFormatting /> <w:PunctuationKerning /> <w:ValidateAgainstSchemas /> <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false</w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText> <w:DoNotPromoteQF /> <w:LidThemeOther>EN-US</w:LidThemeOther> <w:LidThemeAsian>X-NONE</w:LidThemeAsian> <w:LidThemeComplexScript>AR-SA</w:LidThemeComplexScript> <w:Compatibility> <w:BreakWrappedTables /> <w:SnapToGridInCell /> <w:WrapTextWithPunct /> <w:UseAsianBreakRules /> <w:DontGrowAutofit /> <w:SplitPgBreakAndParaMark /> <w:DontVertAlignCellWithSp /> <w:DontBreakConstrainedForcedTables /> <w:DontVertAlignInTxbx /> <w:Word11KerningPairs /> <w:CachedColBalance /> </w:Compatibility> <m:mathPr> <m:mathFont m:val="Cambria Math" /> <m:brkBin m:val="before" /> <m:brkBinSub m:val=" " /> <m:smallFrac m:val="off" /> <m:dispDef /> <m:lMargin m:val="0" /> <m:rMargin m:val="0" /> <m:defJc m:val="centerGroup" /> <m:wrapIndent m:val="1440" /> <m:intLim m:val="subSup" /> <m:naryLim m:val="undOvr" /> </m:mathPr></w:WordDocument> </xml><![endif]--> <p><strong>BACKGROUND:</strong> Anabolic-androgenic steroids have been associated with several side effects range. This experimental study was conducted to evaluate the effects of nandrolone decanoate (ND, an anabolic steroid) on lipid profile and liver enzymes in rats in Iran.</p> <p><strong>METHODS:</strong> Forty adult male and female of Wistar strain rats were randomly assigned to four groups of 10 animals each: male control, female control, ND - male treated (15 mg/kg b.w./day), and ND - female treated (15 mg/kg b.w./day). Serum concentrations of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were measured in all studied groups.</p> <p><strong>RESULTS:</strong> Treating rats with ND (case group) resulted in a significant elevation of TC (69.4 ± 8.7), TG (101.6 ± 32.9) and ALT (72.2 ± 13.8) and significant reduction of LDL (6.4 ± 2.6) and AST (138.7 ± 19.4) as compared to control group in female rats. ND supplementation (case group) significantly increased TC (64.4 ± 6.2), AST (255.0 ± 32.0), and ALT (84.3 ± 3.8) in comparison with the control group in male rats.</p> <p><strong>CONCLUSION: </strong>Overall, our result indicated that the ND use can cause a negative effect on lipid profile and liver enzyme in rats.</p><p class="MsoNormal" style="margin-bottom: .0001pt; text-align: justify; line-height: 200%; mso-layout-grid-align: none; text-autospace: none; direction: ltr; unicode-bidi: embed;"> </p> <!--[if gte mso 9]><xml> <w:LatentStyles DefLockedState="false" DefUnhideWhenUsed="true" DefSemiHidden="true" DefQFormat="false" DefPriority="99" LatentStyleCount="267"> <w:LsdException Locked="false" Priority="0" SemiHidden="false" UnhideWhenUsed="false" QFormat="true" Name="Normal" /> <w:LsdException Locked="false" Priority="9" SemiHidden="false" UnhideWhenUsed="false" QFormat="true" Name="heading 1" /> <w:LsdException Locked="false" Priority="9" QFormat="true" Name="heading 2" /> 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| first_indexed | 2024-12-11T01:55:10Z |
| format | Article |
| id | doaj.art-ebb820c1dc9449eeb0465226cacf8f08 |
| institution | Directory Open Access Journal |
| issn | 1735-3955 2251-6638 |
| language | English |
| last_indexed | 2024-12-11T01:55:10Z |
| publishDate | 2015-07-01 |
| publisher | Vesnu Publications |
| record_format | Article |
| series | ARYA Atherosclerosis |
| spelling | doaj.art-ebb820c1dc9449eeb0465226cacf8f082022-12-22T01:24:38ZengVesnu PublicationsARYA Atherosclerosis1735-39552251-66382015-07-01114256260534Influence of nandrolone decanoate administration on serum lipids and liver enzymes in ratsMohammad Reza Samieinasab0Mohammad Reza Shahraki1Fatemah Samieinasab2Somayeh Najafi3Assistant Professor, Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranAssociate Professor, Department of Physiology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, IranAyatollah Golpayegani Hospital, Qom University of Medical Sciences, Qom, IranMsc Student, Cardiac Rehabilitation research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran<!--[if gte mso 9]><xml> <w:WordDocument> <w:View>Normal</w:View> <w:Zoom>0</w:Zoom> <w:TrackMoves /> <w:TrackFormatting /> <w:PunctuationKerning /> <w:ValidateAgainstSchemas /> <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false</w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText> <w:DoNotPromoteQF /> <w:LidThemeOther>EN-US</w:LidThemeOther> <w:LidThemeAsian>X-NONE</w:LidThemeAsian> <w:LidThemeComplexScript>AR-SA</w:LidThemeComplexScript> <w:Compatibility> <w:BreakWrappedTables /> <w:SnapToGridInCell /> <w:WrapTextWithPunct /> <w:UseAsianBreakRules /> <w:DontGrowAutofit /> <w:SplitPgBreakAndParaMark /> <w:DontVertAlignCellWithSp /> <w:DontBreakConstrainedForcedTables /> <w:DontVertAlignInTxbx /> <w:Word11KerningPairs /> <w:CachedColBalance /> </w:Compatibility> <m:mathPr> <m:mathFont m:val="Cambria Math" /> <m:brkBin m:val="before" /> <m:brkBinSub m:val=" " /> <m:smallFrac m:val="off" /> <m:dispDef /> <m:lMargin m:val="0" /> <m:rMargin m:val="0" /> <m:defJc m:val="centerGroup" /> <m:wrapIndent m:val="1440" /> <m:intLim m:val="subSup" /> <m:naryLim m:val="undOvr" /> </m:mathPr></w:WordDocument> </xml><![endif]--> <p><strong>BACKGROUND:</strong> Anabolic-androgenic steroids have been associated with several side effects range. This experimental study was conducted to evaluate the effects of nandrolone decanoate (ND, an anabolic steroid) on lipid profile and liver enzymes in rats in Iran.</p> <p><strong>METHODS:</strong> Forty adult male and female of Wistar strain rats were randomly assigned to four groups of 10 animals each: male control, female control, ND - male treated (15 mg/kg b.w./day), and ND - female treated (15 mg/kg b.w./day). Serum concentrations of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were measured in all studied groups.</p> <p><strong>RESULTS:</strong> Treating rats with ND (case group) resulted in a significant elevation of TC (69.4 ± 8.7), TG (101.6 ± 32.9) and ALT (72.2 ± 13.8) and significant reduction of LDL (6.4 ± 2.6) and AST (138.7 ± 19.4) as compared to control group in female rats. ND supplementation (case group) significantly increased TC (64.4 ± 6.2), AST (255.0 ± 32.0), and ALT (84.3 ± 3.8) in comparison with the control group in male rats.</p> <p><strong>CONCLUSION: </strong>Overall, our result indicated that the ND use can cause a negative effect on lipid profile and liver enzyme in rats.</p><p class="MsoNormal" style="margin-bottom: .0001pt; text-align: justify; line-height: 200%; mso-layout-grid-align: none; text-autospace: none; direction: ltr; unicode-bidi: embed;"> </p> <!--[if gte mso 9]><xml> <w:LatentStyles DefLockedState="false" DefUnhideWhenUsed="true" DefSemiHidden="true" DefQFormat="false" DefPriority="99" LatentStyleCount="267"> <w:LsdException Locked="false" Priority="0" SemiHidden="false" UnhideWhenUsed="false" QFormat="true" Name="Normal" /> <w:LsdException Locked="false" Priority="9" SemiHidden="false" UnhideWhenUsed="false" QFormat="true" Name="heading 1" /> <w:LsdException Locked="false" Priority="9" QFormat="true" Name="heading 2" /> 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Heading" /> </w:LatentStyles> </xml><![endif]--><!--[if gte mso 10]> <mce:style><! /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin-top:0cm; mso-para-margin-right:0cm; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0cm; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-language:FA;} --> <!--[endif] -->http://arya.mui.ac.ir/index.php/arya/article/view/879Aspartate Aminotransferase, Nandrolone Decanoate, Rat, Steroids |
| spellingShingle | Mohammad Reza Samieinasab Mohammad Reza Shahraki Fatemah Samieinasab Somayeh Najafi Influence of nandrolone decanoate administration on serum lipids and liver enzymes in rats ARYA Atherosclerosis Aspartate Aminotransferase, Nandrolone Decanoate, Rat, Steroids |
| title | Influence of nandrolone decanoate administration on serum lipids and liver enzymes in rats |
| title_full | Influence of nandrolone decanoate administration on serum lipids and liver enzymes in rats |
| title_fullStr | Influence of nandrolone decanoate administration on serum lipids and liver enzymes in rats |
| title_full_unstemmed | Influence of nandrolone decanoate administration on serum lipids and liver enzymes in rats |
| title_short | Influence of nandrolone decanoate administration on serum lipids and liver enzymes in rats |
| title_sort | influence of nandrolone decanoate administration on serum lipids and liver enzymes in rats |
| topic | Aspartate Aminotransferase, Nandrolone Decanoate, Rat, Steroids |
| url | http://arya.mui.ac.ir/index.php/arya/article/view/879 |
| work_keys_str_mv | AT mohammadrezasamieinasab influenceofnandrolonedecanoateadministrationonserumlipidsandliverenzymesinrats AT mohammadrezashahraki influenceofnandrolonedecanoateadministrationonserumlipidsandliverenzymesinrats AT fatemahsamieinasab influenceofnandrolonedecanoateadministrationonserumlipidsandliverenzymesinrats AT somayehnajafi influenceofnandrolonedecanoateadministrationonserumlipidsandliverenzymesinrats |