Corynebacterium striatum Endocarditis After Renal Transplantation Confirmed by Metagenomic Next-Generation Sequencing: Case Report and Literature Review
Meng-meng Zheng,* Li-min Shang,* Chun-kai Du,* Lei Zhang, Wen Sun, Zhi-peng Wang, Yi-chen Zhu, Ye Tian Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China*These authors contributed equally to this workCor...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-08-01
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| Series: | Infection and Drug Resistance |
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| Online Access: | https://www.dovepress.com/corynebacterium-striatum-endocarditis-after-renal-transplantation-conf-peer-reviewed-fulltext-article-IDR |
| _version_ | 1818482348089409536 |
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| author | Zheng MM Shang LM Du CK Zhang L Sun W Wang ZP Zhu YC Tian Y |
| author_facet | Zheng MM Shang LM Du CK Zhang L Sun W Wang ZP Zhu YC Tian Y |
| author_sort | Zheng MM |
| collection | DOAJ |
| description | Meng-meng Zheng,* Li-min Shang,* Chun-kai Du,* Lei Zhang, Wen Sun, Zhi-peng Wang, Yi-chen Zhu, Ye Tian Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yi-chen Zhu; Ye Tian, Department of Urology, Capital Medical University, Beijing Friendship Hospital, No. 95 Yong’an Road, Xicheng District, Beijing, 100050, People’s Republic of China, Email zhuyc82@sina.com; tianye166@126.comBackground: Potent immune-suppressive therapy has been demonstrated to increase the risk of infective endocarditis (IE) in renal recipients. Reports of Corynebacterium striatum (C. striatum) endocarditis in renal recipients are scarce, thus limiting understanding of the disease.Case Presentation: We describe a case of native valve endocarditis caused by C. striatum in a 35-year-old male patient. The young man with end-stage renal failure underwent kidney transplantation because of autosomal dominant polycystic kidney disease. Ceftazidime was administered after the surgery according to routine procedures, and the patient was discharged on the 14th day after the surgery without any evidence of infection. The patient experienced fever on the 56th day, and Corynebacterium was cultured from the patient’s blood, in agreement with the results of testing of the donor kidney preservation solution. On the 64th day, multiple thromboses were found in the right external iliac artery, particularly around the anastomotic orifice of the transplanted renal artery. Vegetation was found in the posterior mitral valve tip on the 65th day. The patient had symptoms of persistent angina pectoris and chest tightness and underwent mitral valve replacement and vegetative resection. The patient eventually died. C. striatum was detected in the mitral valve and vegetation tissue with metagenomic next-generation sequencing.Conclusion: C. striatum may cause endocarditis and endanger patients’ lives and thus warrants greater attention. Genotypic assays such as metagenomic next-generation sequencing are demonstrated to be effective in confirming species identity. Adequate anti-infection therapy and early surgery are required after IE is discovered.Keywords: kidney transplantation, infection, endocarditis, Corynebacterium striatum, case report |
| first_indexed | 2024-12-10T11:46:33Z |
| format | Article |
| id | doaj.art-ebba657edca94c2aa8c59b37933bd138 |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-12-10T11:46:33Z |
| publishDate | 2022-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-ebba657edca94c2aa8c59b37933bd1382022-12-22T01:50:04ZengDove Medical PressInfection and Drug Resistance1178-69732022-08-01Volume 154899490677719Corynebacterium striatum Endocarditis After Renal Transplantation Confirmed by Metagenomic Next-Generation Sequencing: Case Report and Literature ReviewZheng MMShang LMDu CKZhang LSun WWang ZPZhu YCTian YMeng-meng Zheng,* Li-min Shang,* Chun-kai Du,* Lei Zhang, Wen Sun, Zhi-peng Wang, Yi-chen Zhu, Ye Tian Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yi-chen Zhu; Ye Tian, Department of Urology, Capital Medical University, Beijing Friendship Hospital, No. 95 Yong’an Road, Xicheng District, Beijing, 100050, People’s Republic of China, Email zhuyc82@sina.com; tianye166@126.comBackground: Potent immune-suppressive therapy has been demonstrated to increase the risk of infective endocarditis (IE) in renal recipients. Reports of Corynebacterium striatum (C. striatum) endocarditis in renal recipients are scarce, thus limiting understanding of the disease.Case Presentation: We describe a case of native valve endocarditis caused by C. striatum in a 35-year-old male patient. The young man with end-stage renal failure underwent kidney transplantation because of autosomal dominant polycystic kidney disease. Ceftazidime was administered after the surgery according to routine procedures, and the patient was discharged on the 14th day after the surgery without any evidence of infection. The patient experienced fever on the 56th day, and Corynebacterium was cultured from the patient’s blood, in agreement with the results of testing of the donor kidney preservation solution. On the 64th day, multiple thromboses were found in the right external iliac artery, particularly around the anastomotic orifice of the transplanted renal artery. Vegetation was found in the posterior mitral valve tip on the 65th day. The patient had symptoms of persistent angina pectoris and chest tightness and underwent mitral valve replacement and vegetative resection. The patient eventually died. C. striatum was detected in the mitral valve and vegetation tissue with metagenomic next-generation sequencing.Conclusion: C. striatum may cause endocarditis and endanger patients’ lives and thus warrants greater attention. Genotypic assays such as metagenomic next-generation sequencing are demonstrated to be effective in confirming species identity. Adequate anti-infection therapy and early surgery are required after IE is discovered.Keywords: kidney transplantation, infection, endocarditis, Corynebacterium striatum, case reporthttps://www.dovepress.com/corynebacterium-striatum-endocarditis-after-renal-transplantation-conf-peer-reviewed-fulltext-article-IDRkidney transplantationinfectionendocarditiscorynebacterium striatumcase report |
| spellingShingle | Zheng MM Shang LM Du CK Zhang L Sun W Wang ZP Zhu YC Tian Y Corynebacterium striatum Endocarditis After Renal Transplantation Confirmed by Metagenomic Next-Generation Sequencing: Case Report and Literature Review Infection and Drug Resistance kidney transplantation infection endocarditis corynebacterium striatum case report |
| title | Corynebacterium striatum Endocarditis After Renal Transplantation Confirmed by Metagenomic Next-Generation Sequencing: Case Report and Literature Review |
| title_full | Corynebacterium striatum Endocarditis After Renal Transplantation Confirmed by Metagenomic Next-Generation Sequencing: Case Report and Literature Review |
| title_fullStr | Corynebacterium striatum Endocarditis After Renal Transplantation Confirmed by Metagenomic Next-Generation Sequencing: Case Report and Literature Review |
| title_full_unstemmed | Corynebacterium striatum Endocarditis After Renal Transplantation Confirmed by Metagenomic Next-Generation Sequencing: Case Report and Literature Review |
| title_short | Corynebacterium striatum Endocarditis After Renal Transplantation Confirmed by Metagenomic Next-Generation Sequencing: Case Report and Literature Review |
| title_sort | corynebacterium striatum endocarditis after renal transplantation confirmed by metagenomic next generation sequencing case report and literature review |
| topic | kidney transplantation infection endocarditis corynebacterium striatum case report |
| url | https://www.dovepress.com/corynebacterium-striatum-endocarditis-after-renal-transplantation-conf-peer-reviewed-fulltext-article-IDR |
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