A Randomized Controlled Trial on the Influence of Prenatal Counseling on the Attitudes and Preferences Toward Invasive Prenatal Testing Among Women in Their First Trimester of Pregnancy (INVASIVE)
ObjectiveTo assess the impact of prenatal genetic counseling on the attitudes and preferences toward invasive testing in first-trimester pregnant women.MethodsThis is a randomized open-label study, of pregnant women undergoing first trimester combined screening for aneuploidies. Women were divided i...
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| Format: | Article |
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Frontiers Media S.A.
2020-11-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2020.561283/full |
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| author | Fernanda Paz y Miño Fernanda Paz y Miño Raigam Jafet Martinez-Portilla Raigam Jafet Martinez-Portilla Raigam Jafet Martinez-Portilla Montse Pauta Antoni Borrell |
| author_facet | Fernanda Paz y Miño Fernanda Paz y Miño Raigam Jafet Martinez-Portilla Raigam Jafet Martinez-Portilla Raigam Jafet Martinez-Portilla Montse Pauta Antoni Borrell |
| author_sort | Fernanda Paz y Miño |
| collection | DOAJ |
| description | ObjectiveTo assess the impact of prenatal genetic counseling on the attitudes and preferences toward invasive testing in first-trimester pregnant women.MethodsThis is a randomized open-label study, of pregnant women undergoing first trimester combined screening for aneuploidies. Women were divided into the experimental or control groups in a 1:1 design. The intervention consisted of 15-min extra counseling about prenatal screening and diagnosis. The main outcome was the desire to choose an invasive testing as their first prenatal testing option which was measured as absolute risk.ResultsAfter excluding those with incomplete data, 75 women remained in the experimental group and 75 as controls. Women receiving counseling were 32% more likely to choose an invasive prenatal testing as their first-line option after extra 15-min extensive counseling, reducing the first-trimester combined screening by 20% and the cell-free DNA by 12%. If given the opportunity, 59% of the women would like to be able to choose the prenatal test that suits their needs.ConclusionWomen given an extensive prenatal counseling are more likely to choose an invasive testing as their first-line test in spite of the concerning risks.Clinical Trial Registrationwww.ClinicalTrials.gov, identifier NCT04119349. |
| first_indexed | 2024-12-23T11:22:09Z |
| format | Article |
| id | doaj.art-ebba95f111fc45509b629fb2b36d5ad5 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-23T11:22:09Z |
| publishDate | 2020-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-ebba95f111fc45509b629fb2b36d5ad52022-12-21T17:49:04ZengFrontiers Media S.A.Frontiers in Genetics1664-80212020-11-011110.3389/fgene.2020.561283561283A Randomized Controlled Trial on the Influence of Prenatal Counseling on the Attitudes and Preferences Toward Invasive Prenatal Testing Among Women in Their First Trimester of Pregnancy (INVASIVE)Fernanda Paz y Miño0Fernanda Paz y Miño1Raigam Jafet Martinez-Portilla2Raigam Jafet Martinez-Portilla3Raigam Jafet Martinez-Portilla4Montse Pauta5Antoni Borrell6Fetal Medicine Research Center, BCNatal – Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Deu), Institut Clínic de Ginecologia, Obstetricia i Neonatologia, Universitat de Barcelona, Barcelona, SpainPrenatal Diagnosis Unit, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, SpainFetal Medicine Research Center, BCNatal – Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Deu), Institut Clínic de Ginecologia, Obstetricia i Neonatologia, Universitat de Barcelona, Barcelona, SpainPrenatal Diagnosis Unit, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, SpainClinical Research Department, National Institute of Perinatology, Mexico City, MexicoPrenatal Diagnosis Unit, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, SpainPrenatal Diagnosis Unit, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, SpainObjectiveTo assess the impact of prenatal genetic counseling on the attitudes and preferences toward invasive testing in first-trimester pregnant women.MethodsThis is a randomized open-label study, of pregnant women undergoing first trimester combined screening for aneuploidies. Women were divided into the experimental or control groups in a 1:1 design. The intervention consisted of 15-min extra counseling about prenatal screening and diagnosis. The main outcome was the desire to choose an invasive testing as their first prenatal testing option which was measured as absolute risk.ResultsAfter excluding those with incomplete data, 75 women remained in the experimental group and 75 as controls. Women receiving counseling were 32% more likely to choose an invasive prenatal testing as their first-line option after extra 15-min extensive counseling, reducing the first-trimester combined screening by 20% and the cell-free DNA by 12%. If given the opportunity, 59% of the women would like to be able to choose the prenatal test that suits their needs.ConclusionWomen given an extensive prenatal counseling are more likely to choose an invasive testing as their first-line test in spite of the concerning risks.Clinical Trial Registrationwww.ClinicalTrials.gov, identifier NCT04119349.https://www.frontiersin.org/articles/10.3389/fgene.2020.561283/fullcell free DNA testinginvasive testingprenatal genetic counselingrandomized-controlled trialfetal aneuploidy detection |
| spellingShingle | Fernanda Paz y Miño Fernanda Paz y Miño Raigam Jafet Martinez-Portilla Raigam Jafet Martinez-Portilla Raigam Jafet Martinez-Portilla Montse Pauta Antoni Borrell A Randomized Controlled Trial on the Influence of Prenatal Counseling on the Attitudes and Preferences Toward Invasive Prenatal Testing Among Women in Their First Trimester of Pregnancy (INVASIVE) Frontiers in Genetics cell free DNA testing invasive testing prenatal genetic counseling randomized-controlled trial fetal aneuploidy detection |
| title | A Randomized Controlled Trial on the Influence of Prenatal Counseling on the Attitudes and Preferences Toward Invasive Prenatal Testing Among Women in Their First Trimester of Pregnancy (INVASIVE) |
| title_full | A Randomized Controlled Trial on the Influence of Prenatal Counseling on the Attitudes and Preferences Toward Invasive Prenatal Testing Among Women in Their First Trimester of Pregnancy (INVASIVE) |
| title_fullStr | A Randomized Controlled Trial on the Influence of Prenatal Counseling on the Attitudes and Preferences Toward Invasive Prenatal Testing Among Women in Their First Trimester of Pregnancy (INVASIVE) |
| title_full_unstemmed | A Randomized Controlled Trial on the Influence of Prenatal Counseling on the Attitudes and Preferences Toward Invasive Prenatal Testing Among Women in Their First Trimester of Pregnancy (INVASIVE) |
| title_short | A Randomized Controlled Trial on the Influence of Prenatal Counseling on the Attitudes and Preferences Toward Invasive Prenatal Testing Among Women in Their First Trimester of Pregnancy (INVASIVE) |
| title_sort | randomized controlled trial on the influence of prenatal counseling on the attitudes and preferences toward invasive prenatal testing among women in their first trimester of pregnancy invasive |
| topic | cell free DNA testing invasive testing prenatal genetic counseling randomized-controlled trial fetal aneuploidy detection |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2020.561283/full |
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