Cutaneous T-cell lymphoma developing in surgical scars post cardiac surgery: A case study
Cutaneous T-cell lymphomas are a class of non-Hodgkin lymphomas characterized by the infiltration of malignant T cells into the skin. Their precise pathogenesis remains incompletely understood, but persistent and specific antigen stimulation of skin-homing CD4+ memory T cells by external or internal...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2023-03-01
|
| Series: | SAGE Open Medical Case Reports |
| Online Access: | https://doi.org/10.1177/2050313X231161444 |
| _version_ | 1827985564122480640 |
|---|---|
| author | Sarah J Touyz Feras M Ghazawi Elena Netchiporouk Gizelle Popradi René P Michel Sonia Skamene Christine Lambert Tarek Hijal Ivan V Litvinov |
| author_facet | Sarah J Touyz Feras M Ghazawi Elena Netchiporouk Gizelle Popradi René P Michel Sonia Skamene Christine Lambert Tarek Hijal Ivan V Litvinov |
| author_sort | Sarah J Touyz |
| collection | DOAJ |
| description | Cutaneous T-cell lymphomas are a class of non-Hodgkin lymphomas characterized by the infiltration of malignant T cells into the skin. Their precise pathogenesis remains incompletely understood, but persistent and specific antigen stimulation of skin-homing CD4+ memory T cells by external or internal factors, combined with an inflammatory cytokine-rich tissue microenvironment, may be critical in the development of cutaneous T-cell lymphomas. We present herein a case of primary cutaneous T-cell lymphoma arising in two surgical scars that developed 6 months post-operatively and were successfully treated with external beam radiotherapy. This case highlights the notion that primary cutaneous T-cell lymphoma can develop locally at the site of injury/foreign body within a relatively short time post trauma/surgery. This work contributes to the literature of cutaneous T-cell lymphomas arising after a trauma, surgery, or a foreign body. |
| first_indexed | 2024-04-09T23:16:58Z |
| format | Article |
| id | doaj.art-ebbb306902df46aeb357496b7dcca9c6 |
| institution | Directory Open Access Journal |
| issn | 2050-313X |
| language | English |
| last_indexed | 2024-04-09T23:16:58Z |
| publishDate | 2023-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | SAGE Open Medical Case Reports |
| spelling | doaj.art-ebbb306902df46aeb357496b7dcca9c62023-03-22T08:03:23ZengSAGE PublishingSAGE Open Medical Case Reports2050-313X2023-03-011110.1177/2050313X231161444Cutaneous T-cell lymphoma developing in surgical scars post cardiac surgery: A case studySarah J Touyz0Feras M Ghazawi1Elena Netchiporouk2Gizelle Popradi3René P Michel4Sonia Skamene5Christine Lambert6Tarek Hijal7Ivan V Litvinov8Department of Acute Internal Medicine, Salford Royal NHS Foundation Trust, Salford, UKDivision of Dermatology, University of Ottawa, Ottawa, ON, CanadaDivision of Dermatology, McGill University Health Centre, Montreal, QC, CanadaDivision of Hematology, McGill University Health Centre, Montreal, QC, CanadaDepartment of Pathology, McGill University, Montreal, QC, CanadaDepartment of Radiation Oncology, McGill University Health Centre, Montreal, QC, CanadaDepartment of Radiation Oncology, McGill University Health Centre, Montreal, QC, CanadaDepartment of Radiation Oncology, McGill University Health Centre, Montreal, QC, CanadaDivision of Dermatology, McGill University Health Centre, Montreal, QC, CanadaCutaneous T-cell lymphomas are a class of non-Hodgkin lymphomas characterized by the infiltration of malignant T cells into the skin. Their precise pathogenesis remains incompletely understood, but persistent and specific antigen stimulation of skin-homing CD4+ memory T cells by external or internal factors, combined with an inflammatory cytokine-rich tissue microenvironment, may be critical in the development of cutaneous T-cell lymphomas. We present herein a case of primary cutaneous T-cell lymphoma arising in two surgical scars that developed 6 months post-operatively and were successfully treated with external beam radiotherapy. This case highlights the notion that primary cutaneous T-cell lymphoma can develop locally at the site of injury/foreign body within a relatively short time post trauma/surgery. This work contributes to the literature of cutaneous T-cell lymphomas arising after a trauma, surgery, or a foreign body.https://doi.org/10.1177/2050313X231161444 |
| spellingShingle | Sarah J Touyz Feras M Ghazawi Elena Netchiporouk Gizelle Popradi René P Michel Sonia Skamene Christine Lambert Tarek Hijal Ivan V Litvinov Cutaneous T-cell lymphoma developing in surgical scars post cardiac surgery: A case study SAGE Open Medical Case Reports |
| title | Cutaneous T-cell lymphoma developing in surgical scars post cardiac surgery: A case study |
| title_full | Cutaneous T-cell lymphoma developing in surgical scars post cardiac surgery: A case study |
| title_fullStr | Cutaneous T-cell lymphoma developing in surgical scars post cardiac surgery: A case study |
| title_full_unstemmed | Cutaneous T-cell lymphoma developing in surgical scars post cardiac surgery: A case study |
| title_short | Cutaneous T-cell lymphoma developing in surgical scars post cardiac surgery: A case study |
| title_sort | cutaneous t cell lymphoma developing in surgical scars post cardiac surgery a case study |
| url | https://doi.org/10.1177/2050313X231161444 |
| work_keys_str_mv | AT sarahjtouyz cutaneoustcelllymphomadevelopinginsurgicalscarspostcardiacsurgeryacasestudy AT ferasmghazawi cutaneoustcelllymphomadevelopinginsurgicalscarspostcardiacsurgeryacasestudy AT elenanetchiporouk cutaneoustcelllymphomadevelopinginsurgicalscarspostcardiacsurgeryacasestudy AT gizellepopradi cutaneoustcelllymphomadevelopinginsurgicalscarspostcardiacsurgeryacasestudy AT renepmichel cutaneoustcelllymphomadevelopinginsurgicalscarspostcardiacsurgeryacasestudy AT soniaskamene cutaneoustcelllymphomadevelopinginsurgicalscarspostcardiacsurgeryacasestudy AT christinelambert cutaneoustcelllymphomadevelopinginsurgicalscarspostcardiacsurgeryacasestudy AT tarekhijal cutaneoustcelllymphomadevelopinginsurgicalscarspostcardiacsurgeryacasestudy AT ivanvlitvinov cutaneoustcelllymphomadevelopinginsurgicalscarspostcardiacsurgeryacasestudy |