Research Progress on the Role of NLRP3 Inflammasome and Microglia in Cognitive Impairment
As a common neurological disease, cognitive impairment is characterized by cognitive decline, memory and attention impairment, which seriously affects the patients' quality of life. The etiology and pathogenesis of cognitive impairment are complex and diverse. Studies have shown that chronic pe...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | zho |
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Editorial Office of Medical Journal of Peking Union Medical College Hospital
2023-11-01
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| Series: | Xiehe Yixue Zazhi |
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| Online Access: | https://xhyxzz.pumch.cn/en/article/doi/10.12290/xhyxzz.2023-0217 |
| _version_ | 1797405538966831104 |
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| author | WANG Caihong LIU Rongxin TANG Feng WEI Xiaotao XU Ziqing HOU Huaijing ZHANG Jie ZHAO Yongqiang XUE Jianjun |
| author_facet | WANG Caihong LIU Rongxin TANG Feng WEI Xiaotao XU Ziqing HOU Huaijing ZHANG Jie ZHAO Yongqiang XUE Jianjun |
| author_sort | WANG Caihong |
| collection | DOAJ |
| description | As a common neurological disease, cognitive impairment is characterized by cognitive decline, memory and attention impairment, which seriously affects the patients' quality of life. The etiology and pathogenesis of cognitive impairment are complex and diverse. Studies have shown that chronic persistent neuroinflammation plays a key role in its development. Microglia and nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome are closely related to neuroinflammation and cognitive impairment. Regulation of microglia and NLRP3 inflammasome can reduce inflammatory factors, reduce amyloid β-protein(Aβ) deposition, regulate autophagy, maintain synaptic homeostasis, thus reducing neuroinflammation and further preventing and treating cognitive impairment. Therefore, exploring the mechanism of microglia and NLRP3 inflammasome as well as their interaction in cognitive impairment can provide some reference and basis for the in-depth study of the mechanism and clinical prevention and treatment of cognitive impairment, and the subsequent development of more efficient drugs. |
| first_indexed | 2024-03-09T03:12:23Z |
| format | Article |
| id | doaj.art-ebbb5c95fd0148eead5207a3349454a6 |
| institution | Directory Open Access Journal |
| issn | 1674-9081 |
| language | zho |
| last_indexed | 2024-03-09T03:12:23Z |
| publishDate | 2023-11-01 |
| publisher | Editorial Office of Medical Journal of Peking Union Medical College Hospital |
| record_format | Article |
| series | Xiehe Yixue Zazhi |
| spelling | doaj.art-ebbb5c95fd0148eead5207a3349454a62023-12-04T02:50:32ZzhoEditorial Office of Medical Journal of Peking Union Medical College HospitalXiehe Yixue Zazhi1674-90812023-11-011461282128810.12290/xhyxzz.2023-0217Research Progress on the Role of NLRP3 Inflammasome and Microglia in Cognitive ImpairmentWANG Caihong0LIU Rongxin1TANG Feng2WEI Xiaotao3XU ZiqingHOU HuaijingZHANG JieZHAO Yongqiang4XUE JianjunFirst Clinical Medical School, Gansu University of Chinese Medicine, Lanzhou 730000, ChinaFirst Clinical Medical School, Gansu University of Chinese Medicine, Lanzhou 730000, ChinaFirst Clinical Medical School, Gansu University of Chinese Medicine, Lanzhou 730000, ChinaFirst Clinical Medical School, Gansu University of Chinese Medicine, Lanzhou 730000, ChinaDepartment of Urology, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730000, ChinaAs a common neurological disease, cognitive impairment is characterized by cognitive decline, memory and attention impairment, which seriously affects the patients' quality of life. The etiology and pathogenesis of cognitive impairment are complex and diverse. Studies have shown that chronic persistent neuroinflammation plays a key role in its development. Microglia and nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome are closely related to neuroinflammation and cognitive impairment. Regulation of microglia and NLRP3 inflammasome can reduce inflammatory factors, reduce amyloid β-protein(Aβ) deposition, regulate autophagy, maintain synaptic homeostasis, thus reducing neuroinflammation and further preventing and treating cognitive impairment. Therefore, exploring the mechanism of microglia and NLRP3 inflammasome as well as their interaction in cognitive impairment can provide some reference and basis for the in-depth study of the mechanism and clinical prevention and treatment of cognitive impairment, and the subsequent development of more efficient drugs.https://xhyxzz.pumch.cn/en/article/doi/10.12290/xhyxzz.2023-0217microglianlrp3 inflammasomecognitive dysfunctionneuroinflammationresearch progress |
| spellingShingle | WANG Caihong LIU Rongxin TANG Feng WEI Xiaotao XU Ziqing HOU Huaijing ZHANG Jie ZHAO Yongqiang XUE Jianjun Research Progress on the Role of NLRP3 Inflammasome and Microglia in Cognitive Impairment Xiehe Yixue Zazhi microglia nlrp3 inflammasome cognitive dysfunction neuroinflammation research progress |
| title | Research Progress on the Role of NLRP3 Inflammasome and Microglia in Cognitive Impairment |
| title_full | Research Progress on the Role of NLRP3 Inflammasome and Microglia in Cognitive Impairment |
| title_fullStr | Research Progress on the Role of NLRP3 Inflammasome and Microglia in Cognitive Impairment |
| title_full_unstemmed | Research Progress on the Role of NLRP3 Inflammasome and Microglia in Cognitive Impairment |
| title_short | Research Progress on the Role of NLRP3 Inflammasome and Microglia in Cognitive Impairment |
| title_sort | research progress on the role of nlrp3 inflammasome and microglia in cognitive impairment |
| topic | microglia nlrp3 inflammasome cognitive dysfunction neuroinflammation research progress |
| url | https://xhyxzz.pumch.cn/en/article/doi/10.12290/xhyxzz.2023-0217 |
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