Viroid-induced DNA methylation in plants
In eukaryotes, DNA methylation refers to the addition of a methyl group to the fifth atom in the six-atom ring of cytosine residues. At least in plants, DNA regions that become de novo methylated can be defined by homologous RNA molecules in a process termed RNA-directed DNA methylation (RdDM). RdDM...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2013-12-01
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| Series: | Biomolecular Concepts |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/bmc-2013-0030 |
| _version_ | 1818677773038780416 |
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| author | Dalakouras Athanasios Dadami Elena Wassenegger Michael |
| author_facet | Dalakouras Athanasios Dadami Elena Wassenegger Michael |
| author_sort | Dalakouras Athanasios |
| collection | DOAJ |
| description | In eukaryotes, DNA methylation refers to the addition of a methyl group to the fifth atom in the six-atom ring of cytosine residues. At least in plants, DNA regions that become de novo methylated can be defined by homologous RNA molecules in a process termed RNA-directed DNA methylation (RdDM). RdDM was first discovered in viroid-infected plants. Viroids are pathogenic circular, non-coding, single-stranded RNA molecules. Members of the Pospiviroidae family replicate in the nucleus through double-stranded RNA intermediates, attracting the host RNA silencing machinery. The recruitment of this machinery results in the production of viroid-derived small RNAs (vd-sRNAs) that mediate RNA degradation and DNA methylation of cognate sequences. Here, we provide an overview of the cumulative data on the field of viroid-induced RdDM and discuss three possible scenarios concerning the mechanistic details of its establishment. |
| first_indexed | 2024-12-17T09:04:41Z |
| format | Article |
| id | doaj.art-ebbdd6259c15413aaa33c8f5e4591817 |
| institution | Directory Open Access Journal |
| issn | 1868-5021 1868-503X |
| language | English |
| last_indexed | 2024-12-17T09:04:41Z |
| publishDate | 2013-12-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Biomolecular Concepts |
| spelling | doaj.art-ebbdd6259c15413aaa33c8f5e45918172022-12-21T21:55:34ZengDe GruyterBiomolecular Concepts1868-50211868-503X2013-12-014655756510.1515/bmc-2013-0030Viroid-induced DNA methylation in plantsDalakouras Athanasios0Dadami Elena1Wassenegger MichaelAlPlanta-Institute for Plant Research, RLP AgroScience GmbH, Breitenweg 71, D-67435 Neustadt, GermanyAlPlanta-Institute for Plant Research, RLP AgroScience GmbH, Breitenweg 71, D-67435 Neustadt, GermanyIn eukaryotes, DNA methylation refers to the addition of a methyl group to the fifth atom in the six-atom ring of cytosine residues. At least in plants, DNA regions that become de novo methylated can be defined by homologous RNA molecules in a process termed RNA-directed DNA methylation (RdDM). RdDM was first discovered in viroid-infected plants. Viroids are pathogenic circular, non-coding, single-stranded RNA molecules. Members of the Pospiviroidae family replicate in the nucleus through double-stranded RNA intermediates, attracting the host RNA silencing machinery. The recruitment of this machinery results in the production of viroid-derived small RNAs (vd-sRNAs) that mediate RNA degradation and DNA methylation of cognate sequences. Here, we provide an overview of the cumulative data on the field of viroid-induced RdDM and discuss three possible scenarios concerning the mechanistic details of its establishment.https://doi.org/10.1515/bmc-2013-0030bisuflite sequencingpotato spindle tuber viroidrna-directed dna methylationsmall rnas |
| spellingShingle | Dalakouras Athanasios Dadami Elena Wassenegger Michael Viroid-induced DNA methylation in plants Biomolecular Concepts bisuflite sequencing potato spindle tuber viroid rna-directed dna methylation small rnas |
| title | Viroid-induced DNA methylation in plants |
| title_full | Viroid-induced DNA methylation in plants |
| title_fullStr | Viroid-induced DNA methylation in plants |
| title_full_unstemmed | Viroid-induced DNA methylation in plants |
| title_short | Viroid-induced DNA methylation in plants |
| title_sort | viroid induced dna methylation in plants |
| topic | bisuflite sequencing potato spindle tuber viroid rna-directed dna methylation small rnas |
| url | https://doi.org/10.1515/bmc-2013-0030 |
| work_keys_str_mv | AT dalakourasathanasios viroidinduceddnamethylationinplants AT dadamielena viroidinduceddnamethylationinplants AT wasseneggermichael viroidinduceddnamethylationinplants |