Causes of Death After Colorectal Cancer Diagnosis: A Population-Based Study

Background: Non-cancer causes of death in patients with colorectal cancer (CRC) have not received much attention until now. The purpose of the current study is to investigate the non-cancer causes of death in patients with CRC at different periods of latency.Methods: Eligible patients with CRC were...

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Main Authors: Yuqian Feng, Huimin Jin, Kaibo Guo, Harpreet S. Wasan, Shanming Ruan, Cihui Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Oncology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.647179/full
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author Yuqian Feng
Huimin Jin
Kaibo Guo
Harpreet S. Wasan
Shanming Ruan
Cihui Chen
author_facet Yuqian Feng
Huimin Jin
Kaibo Guo
Harpreet S. Wasan
Shanming Ruan
Cihui Chen
author_sort Yuqian Feng
collection DOAJ
description Background: Non-cancer causes of death in patients with colorectal cancer (CRC) have not received much attention until now. The purpose of the current study is to investigate the non-cancer causes of death in patients with CRC at different periods of latency.Methods: Eligible patients with CRC were included from the Surveillance, Epidemiology, and End Results (SEER) database, and standardized mortality ratios (SMRs) were calculated using the SEER*Stat software 8.3.8.Results: A total of 475,771 patients with CRC were included, of whom 230,841 patients died during the follow-up period. Within 5 years, CRC was the leading cause of death. Over time, non-cancer causes of death account for an increasing proportion. When followed up for more than 10 years, non-cancer deaths accounted for 71.9% of all deaths worldwide. Cardiovascular diseases were the most common causes of non-cancer deaths, accounting for 15.4% of the total mortality. Patients had a significantly higher risk of death from septicemia within the first year after diagnosis compared with the general population (SMR, 3.39; 95% CI, 3.11–3.69). Within 5–10 years after CRC diagnosis, patients had a significantly higher risk of death from diabetes mellitus (SMR, 1.27; 95% CI, 1.19–1.36). During the course of more than 10 years, patients with CRC had a significantly higher risk of death from atherosclerosis (SMR 1.47; 95% CI, 1.11–1.9).Conclusions: Although CRC has always been the leading cause of death in patients with CRC, non-cancer causes of death should not be ignored. For patients with cancer, we should not only focus on anti-tumor therapies but also pay attention to the occurrence of other risks to prevent and manage them in advance.
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spelling doaj.art-ebbdea45ddfd425b9bee84f866895fe92022-12-21T22:23:42ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-03-011110.3389/fonc.2021.647179647179Causes of Death After Colorectal Cancer Diagnosis: A Population-Based StudyYuqian Feng0Huimin Jin1Kaibo Guo2Harpreet S. Wasan3Shanming Ruan4Cihui Chen5The First Clinical College of Zhejiang Chinese Medical University, Hangzhou, ChinaThe First Clinical College of Zhejiang Chinese Medical University, Hangzhou, ChinaThe First Clinical College of Zhejiang Chinese Medical University, Hangzhou, ChinaDepartment of Cancer Medicine, Hammersmith Hospital, Imperial College Healthcare National Health Service Trust, London, United KingdomDepartment of Medical Oncology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaDepartment of Medical Oncology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaBackground: Non-cancer causes of death in patients with colorectal cancer (CRC) have not received much attention until now. The purpose of the current study is to investigate the non-cancer causes of death in patients with CRC at different periods of latency.Methods: Eligible patients with CRC were included from the Surveillance, Epidemiology, and End Results (SEER) database, and standardized mortality ratios (SMRs) were calculated using the SEER*Stat software 8.3.8.Results: A total of 475,771 patients with CRC were included, of whom 230,841 patients died during the follow-up period. Within 5 years, CRC was the leading cause of death. Over time, non-cancer causes of death account for an increasing proportion. When followed up for more than 10 years, non-cancer deaths accounted for 71.9% of all deaths worldwide. Cardiovascular diseases were the most common causes of non-cancer deaths, accounting for 15.4% of the total mortality. Patients had a significantly higher risk of death from septicemia within the first year after diagnosis compared with the general population (SMR, 3.39; 95% CI, 3.11–3.69). Within 5–10 years after CRC diagnosis, patients had a significantly higher risk of death from diabetes mellitus (SMR, 1.27; 95% CI, 1.19–1.36). During the course of more than 10 years, patients with CRC had a significantly higher risk of death from atherosclerosis (SMR 1.47; 95% CI, 1.11–1.9).Conclusions: Although CRC has always been the leading cause of death in patients with CRC, non-cancer causes of death should not be ignored. For patients with cancer, we should not only focus on anti-tumor therapies but also pay attention to the occurrence of other risks to prevent and manage them in advance.https://www.frontiersin.org/articles/10.3389/fonc.2021.647179/fullcolorectal cancernon-cancer deathssurveillanceepidemiologyand End Results databasestandardized mortality ratios
spellingShingle Yuqian Feng
Huimin Jin
Kaibo Guo
Harpreet S. Wasan
Shanming Ruan
Cihui Chen
Causes of Death After Colorectal Cancer Diagnosis: A Population-Based Study
Frontiers in Oncology
colorectal cancer
non-cancer deaths
surveillance
epidemiology
and End Results database
standardized mortality ratios
title Causes of Death After Colorectal Cancer Diagnosis: A Population-Based Study
title_full Causes of Death After Colorectal Cancer Diagnosis: A Population-Based Study
title_fullStr Causes of Death After Colorectal Cancer Diagnosis: A Population-Based Study
title_full_unstemmed Causes of Death After Colorectal Cancer Diagnosis: A Population-Based Study
title_short Causes of Death After Colorectal Cancer Diagnosis: A Population-Based Study
title_sort causes of death after colorectal cancer diagnosis a population based study
topic colorectal cancer
non-cancer deaths
surveillance
epidemiology
and End Results database
standardized mortality ratios
url https://www.frontiersin.org/articles/10.3389/fonc.2021.647179/full
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