Cardioaortic dimensions in German landrace pigs derived from cardiac magnetic resonance imaging
Abstract Pigs are frequently applied as animal models in cardiovascular research due to their anatomical and physiological similarity to humans. For study planning and refinement, precise knowledge of the cardioaortic dimensions is essential. In a retrospective single-center study, the cardioaortic...
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| Format: | Article |
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Nature Portfolio
2024-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-52376-x |
| _version_ | 1797276577869856768 |
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| author | Florian Meissner Michelle Costa Galbas Sophie Szvetics Constantin von zur Mühlen Timo Heidt Alexander Maier Michael Bock Martin Czerny Wolfgang Bothe Simon Reiss |
| author_facet | Florian Meissner Michelle Costa Galbas Sophie Szvetics Constantin von zur Mühlen Timo Heidt Alexander Maier Michael Bock Martin Czerny Wolfgang Bothe Simon Reiss |
| author_sort | Florian Meissner |
| collection | DOAJ |
| description | Abstract Pigs are frequently applied as animal models in cardiovascular research due to their anatomical and physiological similarity to humans. For study planning and refinement, precise knowledge of the cardioaortic dimensions is essential. In a retrospective single-center study, the cardioaortic dimensions and left ventricular function of German Landrace pigs were assessed using cardiac MRI. All parameters were compared between male and female pigs and analyzed for correlation with body weight. In total, 15 pigs were included (7 male and 8 female, weight 60.9 ± 7.0 kg). The left ventricle revealed an end-diastolic diameter of 50.5 ± 4.4 mm and an ejection fraction of 51.2 ± 9.8%. The diameters of the ascending and descending aorta were 21.3 ± 2.3 and 16.2 ± 1.4 mm, respectively. There were no significant differences between male and female pigs, except that males had a smaller end-diastolic left ventricular volume (p = 0.041). A moderate correlation was found between body weight and the aortic annulus diameter (R = 0.57, p = 0.027). In conclusion, cardiac MRI allows precise quantification of porcine cardioaortic dimensions. For medical device testing, size differences between pigs and humans should be considered. |
| first_indexed | 2024-03-07T15:30:12Z |
| format | Article |
| id | doaj.art-ebbec4c13d1f488182fbfc64ed47eabc |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:30:12Z |
| publishDate | 2024-01-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj.art-ebbec4c13d1f488182fbfc64ed47eabc2024-03-05T16:30:02ZengNature PortfolioScientific Reports2045-23222024-01-011411910.1038/s41598-024-52376-xCardioaortic dimensions in German landrace pigs derived from cardiac magnetic resonance imagingFlorian Meissner0Michelle Costa Galbas1Sophie Szvetics2Constantin von zur Mühlen3Timo Heidt4Alexander Maier5Michael Bock6Martin Czerny7Wolfgang Bothe8Simon Reiss9Department of Cardiovascular Surgery, University Heart Center Freiburg – Bad Krozingen, Faculty of Medicine, University of FreiburgDepartment of Cardiovascular Surgery, University Heart Center Freiburg – Bad Krozingen, Faculty of Medicine, University of FreiburgDepartment of Cardiovascular Surgery, University Heart Center Freiburg – Bad Krozingen, Faculty of Medicine, University of FreiburgDepartment of Cardiology and Angiology, University Heart Center Freiburg – Bad Krozingen, Faculty of Medicine, University of FreiburgDepartment of Cardiology and Angiology, University Heart Center Freiburg – Bad Krozingen, Faculty of Medicine, University of FreiburgDepartment of Cardiology and Angiology, University Heart Center Freiburg – Bad Krozingen, Faculty of Medicine, University of FreiburgDepartment of Diagnostic and Interventional Radiology, Medical Physics, Faculty of Medicine, University of FreiburgDepartment of Cardiovascular Surgery, University Heart Center Freiburg – Bad Krozingen, Faculty of Medicine, University of FreiburgDepartment of Cardiovascular Surgery, University Heart Center Freiburg – Bad Krozingen, Faculty of Medicine, University of FreiburgDepartment of Diagnostic and Interventional Radiology, Medical Physics, Faculty of Medicine, University of FreiburgAbstract Pigs are frequently applied as animal models in cardiovascular research due to their anatomical and physiological similarity to humans. For study planning and refinement, precise knowledge of the cardioaortic dimensions is essential. In a retrospective single-center study, the cardioaortic dimensions and left ventricular function of German Landrace pigs were assessed using cardiac MRI. All parameters were compared between male and female pigs and analyzed for correlation with body weight. In total, 15 pigs were included (7 male and 8 female, weight 60.9 ± 7.0 kg). The left ventricle revealed an end-diastolic diameter of 50.5 ± 4.4 mm and an ejection fraction of 51.2 ± 9.8%. The diameters of the ascending and descending aorta were 21.3 ± 2.3 and 16.2 ± 1.4 mm, respectively. There were no significant differences between male and female pigs, except that males had a smaller end-diastolic left ventricular volume (p = 0.041). A moderate correlation was found between body weight and the aortic annulus diameter (R = 0.57, p = 0.027). In conclusion, cardiac MRI allows precise quantification of porcine cardioaortic dimensions. For medical device testing, size differences between pigs and humans should be considered.https://doi.org/10.1038/s41598-024-52376-x |
| spellingShingle | Florian Meissner Michelle Costa Galbas Sophie Szvetics Constantin von zur Mühlen Timo Heidt Alexander Maier Michael Bock Martin Czerny Wolfgang Bothe Simon Reiss Cardioaortic dimensions in German landrace pigs derived from cardiac magnetic resonance imaging Scientific Reports |
| title | Cardioaortic dimensions in German landrace pigs derived from cardiac magnetic resonance imaging |
| title_full | Cardioaortic dimensions in German landrace pigs derived from cardiac magnetic resonance imaging |
| title_fullStr | Cardioaortic dimensions in German landrace pigs derived from cardiac magnetic resonance imaging |
| title_full_unstemmed | Cardioaortic dimensions in German landrace pigs derived from cardiac magnetic resonance imaging |
| title_short | Cardioaortic dimensions in German landrace pigs derived from cardiac magnetic resonance imaging |
| title_sort | cardioaortic dimensions in german landrace pigs derived from cardiac magnetic resonance imaging |
| url | https://doi.org/10.1038/s41598-024-52376-x |
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