A case of tick-transmitted Q fever in Lishui, China diagnosed by next-generation sequencing
Q fever is a zoonotic disease caused by Coxiella burnetii . Most patients have non-specific symptoms at onset. In addition, routine diagnostic tests for C. burnetii are not sensitive, and the bacterium cannot grow in general culture medium. The diagnosis of Q fever therefore poses a challenge. This...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2021-09-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/03000605211025398 |
| _version_ | 1831570339182673920 |
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| author | Jinwei Huang Rui Wang Can Gao Yuankai Lü Zhuo Cao Shanshan Deng Changwu Yue |
| author_facet | Jinwei Huang Rui Wang Can Gao Yuankai Lü Zhuo Cao Shanshan Deng Changwu Yue |
| author_sort | Jinwei Huang |
| collection | DOAJ |
| description | Q fever is a zoonotic disease caused by Coxiella burnetii . Most patients have non-specific symptoms at onset. In addition, routine diagnostic tests for C. burnetii are not sensitive, and the bacterium cannot grow in general culture medium. The diagnosis of Q fever therefore poses a challenge. This case study describes a man with a clear history of tick bite who had recurrent fever, pneumonia, and liver damage. Routine tests and bacterial cultures failed to clarify the pathogeny, but laboratory and imaging data suggested infection. After routine tests were exhausted, we detected the presence of C. burnetii in a whole blood sample using next-generation sequencing (NGS). To our knowledge, this is the first report of Q fever associated with Coxiella burnetii detected directly from blood samples in Lishui, China. NGS has revolutionized the diagnosis of infectious diseases, especially those caused by rare or newly discovered pathogens, and patient responses have finally proved its substantial benefits. NGS has important clinical significance for the early diagnosis of chronic Q fever. This proof-of-concept study is worthy of promotion in clinical practice. |
| first_indexed | 2024-12-17T12:49:37Z |
| format | Article |
| id | doaj.art-ebbfea249df7400aaa46a877af94cd30 |
| institution | Directory Open Access Journal |
| issn | 1473-2300 |
| language | English |
| last_indexed | 2024-12-17T12:49:37Z |
| publishDate | 2021-09-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-ebbfea249df7400aaa46a877af94cd302022-12-21T21:47:39ZengSAGE PublishingJournal of International Medical Research1473-23002021-09-014910.1177/03000605211025398A case of tick-transmitted Q fever in Lishui, China diagnosed by next-generation sequencingJinwei HuangRui WangCan GaoYuankai LüZhuo CaoShanshan DengChangwu YueQ fever is a zoonotic disease caused by Coxiella burnetii . Most patients have non-specific symptoms at onset. In addition, routine diagnostic tests for C. burnetii are not sensitive, and the bacterium cannot grow in general culture medium. The diagnosis of Q fever therefore poses a challenge. This case study describes a man with a clear history of tick bite who had recurrent fever, pneumonia, and liver damage. Routine tests and bacterial cultures failed to clarify the pathogeny, but laboratory and imaging data suggested infection. After routine tests were exhausted, we detected the presence of C. burnetii in a whole blood sample using next-generation sequencing (NGS). To our knowledge, this is the first report of Q fever associated with Coxiella burnetii detected directly from blood samples in Lishui, China. NGS has revolutionized the diagnosis of infectious diseases, especially those caused by rare or newly discovered pathogens, and patient responses have finally proved its substantial benefits. NGS has important clinical significance for the early diagnosis of chronic Q fever. This proof-of-concept study is worthy of promotion in clinical practice.https://doi.org/10.1177/03000605211025398 |
| spellingShingle | Jinwei Huang Rui Wang Can Gao Yuankai Lü Zhuo Cao Shanshan Deng Changwu Yue A case of tick-transmitted Q fever in Lishui, China diagnosed by next-generation sequencing Journal of International Medical Research |
| title | A case of tick-transmitted Q fever in Lishui, China diagnosed by next-generation sequencing |
| title_full | A case of tick-transmitted Q fever in Lishui, China diagnosed by next-generation sequencing |
| title_fullStr | A case of tick-transmitted Q fever in Lishui, China diagnosed by next-generation sequencing |
| title_full_unstemmed | A case of tick-transmitted Q fever in Lishui, China diagnosed by next-generation sequencing |
| title_short | A case of tick-transmitted Q fever in Lishui, China diagnosed by next-generation sequencing |
| title_sort | case of tick transmitted q fever in lishui china diagnosed by next generation sequencing |
| url | https://doi.org/10.1177/03000605211025398 |
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