Mast cell deficiency improves cognition and enhances disease-associated microglia in 5XFAD mice

Mast cell deficiency improves cognition and enhances disease-associated microglia in 5XFAD mice

Summary: Emerging evidence suggests that peripheral immune cells contribute to Alzheimer’s disease (AD) neuropathogenesis. Among these, mast cells are known for their functions in allergic reactions and neuroinflammation; however, little is known about their role in AD. Here, we crossed 5XFAD mice w...

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Bibliographic Details
Main Authors: Chih-Chung Jerry Lin, Fanny Herisson, Hoang Le, Nader Jaafar, Kashish Chetal, Mary K. Oram, Kelly L. Flynn, Evan P. Gavrilles, Ruslan I. Sadreyev, Felipe L. Schiffino, Rudolph E. Tanzi
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Cell Reports
Subjects:
CP: Neuroscience
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723011531

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