Mechanism of Anti-α-Synuclein Immunotherapy
Immunization therapy targeting α-synuclein has emerged as a promising approach for Parkinson’s disease and perhaps for other synucleinopathies. Several antibodies have shown therapeutic effects in mouse models of synucleinopathies and have alleviated the pathological and behavioral phenotypes of the...
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| Format: | Article |
| Language: | English |
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Korean Movement Disorder Society
2016-01-01
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| Series: | Journal of Movement Disorders |
| Subjects: | |
| Online Access: | http://e-jmd.org/upload/jmd-15059.pdf |
| _version_ | 1797716084977041408 |
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| author | Jun Sung Lee Seung-Jae Lee |
| author_facet | Jun Sung Lee Seung-Jae Lee |
| author_sort | Jun Sung Lee |
| collection | DOAJ |
| description | Immunization therapy targeting α-synuclein has emerged as a promising approach for Parkinson’s disease and perhaps for other synucleinopathies. Several antibodies have shown therapeutic effects in mouse models of synucleinopathies and have alleviated the pathological and behavioral phenotypes of these mice. The mechanisms through which the immunization therapy works were initially puzzling, especially given that α-synuclein is a typical cytosolic protein. Recent studies, however, suggested that extracellular α-synuclein is an important pathogenic entity, and hence, a target for immunotherapy. Here, we review the literature describing immunization therapy for synucleinopathies in mouse models and provide current thoughts on the potential mechanisms underlying the therapeutic effects of α-synuclein immunotherapy. |
| first_indexed | 2024-03-12T08:16:18Z |
| format | Article |
| id | doaj.art-ebc331f95a8b4d7086417ea08efc86d0 |
| institution | Directory Open Access Journal |
| issn | 2005-940X 2093-4939 |
| language | English |
| last_indexed | 2024-03-12T08:16:18Z |
| publishDate | 2016-01-01 |
| publisher | Korean Movement Disorder Society |
| record_format | Article |
| series | Journal of Movement Disorders |
| spelling | doaj.art-ebc331f95a8b4d7086417ea08efc86d02023-09-02T18:53:33ZengKorean Movement Disorder SocietyJournal of Movement Disorders2005-940X2093-49392016-01-0191141910.14802/jmd.15059151Mechanism of Anti-α-Synuclein ImmunotherapyJun Sung LeeSeung-Jae LeeImmunization therapy targeting α-synuclein has emerged as a promising approach for Parkinson’s disease and perhaps for other synucleinopathies. Several antibodies have shown therapeutic effects in mouse models of synucleinopathies and have alleviated the pathological and behavioral phenotypes of these mice. The mechanisms through which the immunization therapy works were initially puzzling, especially given that α-synuclein is a typical cytosolic protein. Recent studies, however, suggested that extracellular α-synuclein is an important pathogenic entity, and hence, a target for immunotherapy. Here, we review the literature describing immunization therapy for synucleinopathies in mouse models and provide current thoughts on the potential mechanisms underlying the therapeutic effects of α-synuclein immunotherapy.http://e-jmd.org/upload/jmd-15059.pdfSynucleinopathyα-synucleinAggregate transmissionMicroglia activationImmunotherapy |
| spellingShingle | Jun Sung Lee Seung-Jae Lee Mechanism of Anti-α-Synuclein Immunotherapy Journal of Movement Disorders Synucleinopathy α-synuclein Aggregate transmission Microglia activation Immunotherapy |
| title | Mechanism of Anti-α-Synuclein Immunotherapy |
| title_full | Mechanism of Anti-α-Synuclein Immunotherapy |
| title_fullStr | Mechanism of Anti-α-Synuclein Immunotherapy |
| title_full_unstemmed | Mechanism of Anti-α-Synuclein Immunotherapy |
| title_short | Mechanism of Anti-α-Synuclein Immunotherapy |
| title_sort | mechanism of anti α synuclein immunotherapy |
| topic | Synucleinopathy α-synuclein Aggregate transmission Microglia activation Immunotherapy |
| url | http://e-jmd.org/upload/jmd-15059.pdf |
| work_keys_str_mv | AT junsunglee mechanismofantiasynucleinimmunotherapy AT seungjaelee mechanismofantiasynucleinimmunotherapy |