The role of gamma knife radiosurgery in occurrence of secondary gliosarcoma after treatment of glioblastoma: A case report
Although the incidence of secondary malignancies due to stereotactic radiosurgery are known to be lower than that of conventional external beam radiation therapy, various instances of secondary malignancy have been reported. We present a rare case of secondary gliosarcoma following gamma knife radio...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-06-01
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| Series: | Interdisciplinary Neurosurgery |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214751920306186 |
| _version_ | 1830161834785636352 |
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| author | Dong wook Kim Hyeong Cheol Moon Young Gyu Kim Yun-Sik Dho |
| author_facet | Dong wook Kim Hyeong Cheol Moon Young Gyu Kim Yun-Sik Dho |
| author_sort | Dong wook Kim |
| collection | DOAJ |
| description | Although the incidence of secondary malignancies due to stereotactic radiosurgery are known to be lower than that of conventional external beam radiation therapy, various instances of secondary malignancy have been reported. We present a rare case of secondary gliosarcoma following gamma knife radiosurgery (GKS) after treatment of glioblastoma. An 81-year-old man underwent navigation-guided biopsy for an incidentally found intra-axial brain tumor in the left temporal lobe. Pathological results demonstrated this was an IDH1 wild-type glioblastoma. Following pathological confirmation, the Stupp regimen was implemented and completed 8 months after the surgery. In a follow-up magnetic resonance imaging (MRI) scan performed 1 year after the surgery, a small residual nodule had increased in size. GKS was performed on this lesion. However, after GKS, the growth rate of the tumor rather accelerated. Based on MRI scans, the tumor significantly increased in size between GKS implementation and a follow-up scan performed at 9 months after GKS. An anterior temporal lobectomy was performed that included the removal of the tumor. Pathology reports confirmed the tumor was a gliosarcoma. |
| first_indexed | 2024-12-17T15:08:52Z |
| format | Article |
| id | doaj.art-ebc3ca84e5fa4f0e95f03b6880fc24ab |
| institution | Directory Open Access Journal |
| issn | 2214-7519 |
| language | English |
| last_indexed | 2024-12-17T15:08:52Z |
| publishDate | 2021-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Interdisciplinary Neurosurgery |
| spelling | doaj.art-ebc3ca84e5fa4f0e95f03b6880fc24ab2022-12-21T21:43:44ZengElsevierInterdisciplinary Neurosurgery2214-75192021-06-0124101057The role of gamma knife radiosurgery in occurrence of secondary gliosarcoma after treatment of glioblastoma: A case reportDong wook Kim0Hyeong Cheol Moon1Young Gyu Kim2Yun-Sik Dho3Department of Neurosurgery, Gamma Knife Icon Center, Chungbuk National University Hospital, Cheongju, Republic of Korea; Department of Neurosurgery, Chungbuk National University, College of Medicine, Cheongju, Republic of KoreaDepartment of Neurosurgery, Gamma Knife Icon Center, Chungbuk National University Hospital, Cheongju, Republic of KoreaDepartment of Neurosurgery, Gamma Knife Icon Center, Chungbuk National University Hospital, Cheongju, Republic of Korea; Department of Neurosurgery, Chungbuk National University, College of Medicine, Cheongju, Republic of KoreaDepartment of Neurosurgery, Gamma Knife Icon Center, Chungbuk National University Hospital, Cheongju, Republic of Korea; Department of Neurosurgery, Chungbuk National University, College of Medicine, Cheongju, Republic of Korea; Corresponding author at: Department of Neurosurgery, Chungbuk National University Hospital, Chungbuk National University College of Medicine, 776, 1 Sunhwanro, Gaesindong, Sewongu, Cheongju 28644, Republic of Korea.Although the incidence of secondary malignancies due to stereotactic radiosurgery are known to be lower than that of conventional external beam radiation therapy, various instances of secondary malignancy have been reported. We present a rare case of secondary gliosarcoma following gamma knife radiosurgery (GKS) after treatment of glioblastoma. An 81-year-old man underwent navigation-guided biopsy for an incidentally found intra-axial brain tumor in the left temporal lobe. Pathological results demonstrated this was an IDH1 wild-type glioblastoma. Following pathological confirmation, the Stupp regimen was implemented and completed 8 months after the surgery. In a follow-up magnetic resonance imaging (MRI) scan performed 1 year after the surgery, a small residual nodule had increased in size. GKS was performed on this lesion. However, after GKS, the growth rate of the tumor rather accelerated. Based on MRI scans, the tumor significantly increased in size between GKS implementation and a follow-up scan performed at 9 months after GKS. An anterior temporal lobectomy was performed that included the removal of the tumor. Pathology reports confirmed the tumor was a gliosarcoma.http://www.sciencedirect.com/science/article/pii/S2214751920306186Gamma knife surgeryGliosarcomaRadiation-induced |
| spellingShingle | Dong wook Kim Hyeong Cheol Moon Young Gyu Kim Yun-Sik Dho The role of gamma knife radiosurgery in occurrence of secondary gliosarcoma after treatment of glioblastoma: A case report Interdisciplinary Neurosurgery Gamma knife surgery Gliosarcoma Radiation-induced |
| title | The role of gamma knife radiosurgery in occurrence of secondary gliosarcoma after treatment of glioblastoma: A case report |
| title_full | The role of gamma knife radiosurgery in occurrence of secondary gliosarcoma after treatment of glioblastoma: A case report |
| title_fullStr | The role of gamma knife radiosurgery in occurrence of secondary gliosarcoma after treatment of glioblastoma: A case report |
| title_full_unstemmed | The role of gamma knife radiosurgery in occurrence of secondary gliosarcoma after treatment of glioblastoma: A case report |
| title_short | The role of gamma knife radiosurgery in occurrence of secondary gliosarcoma after treatment of glioblastoma: A case report |
| title_sort | role of gamma knife radiosurgery in occurrence of secondary gliosarcoma after treatment of glioblastoma a case report |
| topic | Gamma knife surgery Gliosarcoma Radiation-induced |
| url | http://www.sciencedirect.com/science/article/pii/S2214751920306186 |
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