Renal Metabolome in Obese Mice Treated with Empagliflozin Suggests a Reduction in Cellular Respiration

Renal Metabolome in Obese Mice Treated with Empagliflozin Suggests a Reduction in Cellular Respiration

Sodium glucose cotransporter, type 2 inhibitors, such as Empagliflozin, are protective of the kidneys by unclear mechanisms. Our aim was to determine how Empagliflozin affected kidney cortical metabolome and lipidome in mice. Adult male TALLYHO mice (prone to obesity) were treated with a high-milk-f...

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Bibliographic Details
Main Authors: Surabhi Bangarbale, Blythe D. Shepard, Shivani Bansal, Meth M. Jayatilake, Ryan Kurtz, Moshe Levi, Carolyn M. Ecelbarger
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Biomolecules
Subjects:
SGLT2
gluconeogenesis
oxidative phosphorylation
renal
proximal tubule
Online Access:https://www.mdpi.com/2218-273X/12/9/1176

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