Sphingosine-1-Phosphate Alleviates Irradiation Induced Salivary Gland Hypofunction through Preserving Endothelial Cells and Resident Macrophages

Sphingosine-1-Phosphate Alleviates Irradiation Induced Salivary Gland Hypofunction through Preserving Endothelial Cells and Resident Macrophages

Radiotherapy for head-and-neck cancers frequently causes long-term hypofunction of salivary glands that severely compromises quality of life and is difficult to treat. Here, we studied effects and mechanisms of Sphingosine-1-phosphate (S1P), a versatile signaling sphingolipid, in preventing irrevers...

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Bibliographic Details
Main Authors: Tao Yang, Qingguo Zhao, Meijun Hu, Simin Pan, Linying Zhang, Ruoxi Zhu, Bowen Zhou, Xuanhe Feng, Zhenhua Gao, Zhao Zhu, Yu Zhang, Liang Hu, Fei Liu, Zhaochen Shan
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Antioxidants
Subjects:
sphingosine-1-phosphate signaling
salivary glands
irradiation
head and neck cancers
endothelial cells
resident macrophages
Online Access:https://www.mdpi.com/2076-3921/11/10/2050

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