Compromised Dynamic Cerebral Autoregulation in Patients With Idiopathic Rapid Eye Movement Behavior Disorder: A Case-Control Study Using Transcranial Doppler
BackgroundPatients with idiopathic rapid eye movement behavior disorder (IRBD) have been suggested to exhibit altered cerebral perfusion and abnormal cerebral blood flow, which imply a possibility of cerebral autoregulation (CA) impairment. We aimed to investigate the dynamic CA (dCA) in patients wi...
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Frontiers Media S.A.
2020-02-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyt.2020.00051/full |
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| author | Shan Lv Zan Wang Xin Sun Hang Jin Jia Liu Fang Deng Yudan Lv Meiyan Jia Zhen-Ni Guo Yi Yang Yi Yang |
| author_facet | Shan Lv Zan Wang Xin Sun Hang Jin Jia Liu Fang Deng Yudan Lv Meiyan Jia Zhen-Ni Guo Yi Yang Yi Yang |
| author_sort | Shan Lv |
| collection | DOAJ |
| description | BackgroundPatients with idiopathic rapid eye movement behavior disorder (IRBD) have been suggested to exhibit altered cerebral perfusion and abnormal cerebral blood flow, which imply a possibility of cerebral autoregulation (CA) impairment. We aimed to investigate the dynamic CA (dCA) in patients with IRBD during wakefulness and to explore the correlations between dCA parameters and clinical measurements.MethodsWe assessed the dCA capability of 30 patients with IRBD and 36 sex- and age-matched healthy controls by using transcranial Doppler and finger plethysmography. CA function was evaluated by transfer function analysis based on spontaneous oscillation of cerebral blood flow and arterial blood pressure. Transfer function parameters (phase difference and gain) were used to quantify the CA.ResultsNo significant differences were observed between the right and left middle cerebral artery dCA parameters (phase difference and gain) of both groups. Patients with IRBD had significantly lower phase difference than the healthy controls, indicating their impaired CA capability. Besides, the value of gain in patients with IRBD was higher than the healthy controls, but the difference did not reach statistical level.ConclusionsCA function is compromised in patients with IRBD during wakefulness, which might be an intermediate link between IRBD and neurological symptoms. |
| first_indexed | 2024-12-13T20:31:29Z |
| format | Article |
| id | doaj.art-ebc5465cbdc748869deaba47c6840b8a |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-13T20:31:29Z |
| publishDate | 2020-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-ebc5465cbdc748869deaba47c6840b8a2022-12-21T23:32:25ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402020-02-011110.3389/fpsyt.2020.00051493625Compromised Dynamic Cerebral Autoregulation in Patients With Idiopathic Rapid Eye Movement Behavior Disorder: A Case-Control Study Using Transcranial DopplerShan Lv0Zan Wang1Xin Sun2Hang Jin3Jia Liu4Fang Deng5Yudan Lv6Meiyan Jia7Zhen-Ni Guo8Yi Yang9Yi Yang10Department of Neurology, The First Hospital of Jilin University, Changchun, ChinaDepartment of Neurology, The First Hospital of Jilin University, Changchun, ChinaDepartment of Neurology, The First Hospital of Jilin University, Changchun, ChinaDepartment of Neurology, The First Hospital of Jilin University, Changchun, ChinaShenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, ChinaDepartment of Neurology, The First Hospital of Jilin University, Changchun, ChinaDepartment of Neurology, The First Hospital of Jilin University, Changchun, ChinaDepartment of Neurology, The First Hospital of Jilin University, Changchun, ChinaClinical Trial and Research Center for Stroke, Department of Neurology, The First Hospital of Jilin University, Changchun, ChinaDepartment of Neurology, The First Hospital of Jilin University, Changchun, ChinaClinical Trial and Research Center for Stroke, Department of Neurology, The First Hospital of Jilin University, Changchun, ChinaBackgroundPatients with idiopathic rapid eye movement behavior disorder (IRBD) have been suggested to exhibit altered cerebral perfusion and abnormal cerebral blood flow, which imply a possibility of cerebral autoregulation (CA) impairment. We aimed to investigate the dynamic CA (dCA) in patients with IRBD during wakefulness and to explore the correlations between dCA parameters and clinical measurements.MethodsWe assessed the dCA capability of 30 patients with IRBD and 36 sex- and age-matched healthy controls by using transcranial Doppler and finger plethysmography. CA function was evaluated by transfer function analysis based on spontaneous oscillation of cerebral blood flow and arterial blood pressure. Transfer function parameters (phase difference and gain) were used to quantify the CA.ResultsNo significant differences were observed between the right and left middle cerebral artery dCA parameters (phase difference and gain) of both groups. Patients with IRBD had significantly lower phase difference than the healthy controls, indicating their impaired CA capability. Besides, the value of gain in patients with IRBD was higher than the healthy controls, but the difference did not reach statistical level.ConclusionsCA function is compromised in patients with IRBD during wakefulness, which might be an intermediate link between IRBD and neurological symptoms.https://www.frontiersin.org/article/10.3389/fpsyt.2020.00051/fullidiopathic rapid eye movement sleep behavior disordercerebral autoregulationcerebral hemodynamicstranscranial Dopplertransfer function |
| spellingShingle | Shan Lv Zan Wang Xin Sun Hang Jin Jia Liu Fang Deng Yudan Lv Meiyan Jia Zhen-Ni Guo Yi Yang Yi Yang Compromised Dynamic Cerebral Autoregulation in Patients With Idiopathic Rapid Eye Movement Behavior Disorder: A Case-Control Study Using Transcranial Doppler Frontiers in Psychiatry idiopathic rapid eye movement sleep behavior disorder cerebral autoregulation cerebral hemodynamics transcranial Doppler transfer function |
| title | Compromised Dynamic Cerebral Autoregulation in Patients With Idiopathic Rapid Eye Movement Behavior Disorder: A Case-Control Study Using Transcranial Doppler |
| title_full | Compromised Dynamic Cerebral Autoregulation in Patients With Idiopathic Rapid Eye Movement Behavior Disorder: A Case-Control Study Using Transcranial Doppler |
| title_fullStr | Compromised Dynamic Cerebral Autoregulation in Patients With Idiopathic Rapid Eye Movement Behavior Disorder: A Case-Control Study Using Transcranial Doppler |
| title_full_unstemmed | Compromised Dynamic Cerebral Autoregulation in Patients With Idiopathic Rapid Eye Movement Behavior Disorder: A Case-Control Study Using Transcranial Doppler |
| title_short | Compromised Dynamic Cerebral Autoregulation in Patients With Idiopathic Rapid Eye Movement Behavior Disorder: A Case-Control Study Using Transcranial Doppler |
| title_sort | compromised dynamic cerebral autoregulation in patients with idiopathic rapid eye movement behavior disorder a case control study using transcranial doppler |
| topic | idiopathic rapid eye movement sleep behavior disorder cerebral autoregulation cerebral hemodynamics transcranial Doppler transfer function |
| url | https://www.frontiersin.org/article/10.3389/fpsyt.2020.00051/full |
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