Inhibition of cGAS-Mediated Interferon Response Facilitates Transgene Expression

Inhibition of cGAS-Mediated Interferon Response Facilitates Transgene Expression

Summary: DNA transfection is often the bottleneck of research and gene therapy practices. To explore the mechanism regulating transgene expression, we investigated the role of the cGAS-STING signaling pathway, which induces type-I interferons in response to DNA. We confirmed that deletion of cGAS en...

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Bibliographic Details
Main Authors: Yajuan Fu, Yijun Fang, Zhang Lin, Lei Yang, Liqun Zheng, Hao Hu, Tingting Yu, Baoting Huang, Suxing Chen, Hanze Wang, Shan Xu, Wei Bao, Qi Chen, Lijun Sun
Format: Article
Language:English
Published: Elsevier 2020-04-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220302108

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