Chitosan (CHT) and trimethylchitosan (TMC) nanoparticles as adjuvant/delivery system for parenteral and nasal immunization against Mycobacterium tuberculosis (MTb) ESAT-6 antigen

Chitosan (CHT) and trimethylchitosan (TMC) nanoparticles as adjuvant/delivery system for parenteral and nasal immunization against Mycobacterium tuberculosis (MTb) ESAT-6 antigen

Objective(s): An efficient vaccine against TB is an urgent need. TB peptides are safe candidate but they are weak immunogens and needs to be potentiated by adjuvant/delivery systems. The main purpose of the present study was to determine the potential of CHT based NPs containing ESAT-6 antigen of M....

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Bibliographic Details
Main Authors: Seyedeh Mahnaz Karimi, Mojtaba Sankian, Farzad Khademi, Mohsen Tafaghodi
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2016-10-01
Series:Nanomedicine Journal
Subjects:
Chitosan and Trimethylchitosan nanoparticles
ESAT-6 antigen
Mycobacterium tuberculosis
Nasal immunization
Subcutaneous immunization
Online Access:http://nmj.mums.ac.ir/article_7577_a285cb2779cfa2ba6628bb04532ae349.pdf

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