Nonalcoholic fatty liver disease is an independent risk factor for ischemic stroke after revascularization in patients with Moyamoya disease: a prospective cohort study
Abstract Background The study aimed to investigate the association between nonalcoholic fatty liver disease (NAFLD) and ischemic stroke events after revascularization in patients with Moyamoya disease (MMD). Methods This study prospectively enrolled 275 MMD patients from September 2020 to December 2...
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12944-024-02065-5 |
| _version_ | 1797259113334308864 |
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| author | Bojian Zhang Junsheng Li Chaofan Zeng Chuming Tao Qiheng He Chenglong Liu Zhiyao Zheng Zhikang Zhao Siqi Mou Wei Sun Jia Wang Qian Zhang Rong Wang Yan Zhang Peicong Ge Dong Zhang |
| author_facet | Bojian Zhang Junsheng Li Chaofan Zeng Chuming Tao Qiheng He Chenglong Liu Zhiyao Zheng Zhikang Zhao Siqi Mou Wei Sun Jia Wang Qian Zhang Rong Wang Yan Zhang Peicong Ge Dong Zhang |
| author_sort | Bojian Zhang |
| collection | DOAJ |
| description | Abstract Background The study aimed to investigate the association between nonalcoholic fatty liver disease (NAFLD) and ischemic stroke events after revascularization in patients with Moyamoya disease (MMD). Methods This study prospectively enrolled 275 MMD patients from September 2020 to December 2021. Patients with alcoholism and other liver diseases were excluded. NAFLD was confirmed by CT imaging or abdominal ultrasonography. Stroke events and modified Rankin Scale (mRS) scores at the latest follow-up were compared between the two groups. Results A total of 275 patients were enrolled in the study, among which 65 were diagnosed with NAFLD. Univariate logistic regression analysis showed that NAFLD (P = 0.029) was related to stroke events. Multivariate logistic regression analysis showed that NAFLD is a predictor of postoperative stroke in MMD patients (OR = 27.145, 95% CI = 2.031–362.81, P = 0.013). Kaplan-Meier analysis showed that compared with MMD patients with NAFLD, patients in the control group had a longer stroke-free time (P = 0.004). Univariate Cox analysis showed that NAFLD (P = 0.016) was associated with ischemic stroke during follow-up in patients with MMD. Multivariate Cox analysis showed that NAFLD was an independent risk factor for stroke in patients with MMD (HR = 10.815, 95% CI = 1.259–92.881, P = 0.030). Furthermore, fewer patients in the NAFLD group had good neurologic status (mRS score ≤ 2) than the control group (P = 0.005). Conclusion NAFLD was an independent risk factor for stroke in patients with MMD after revascularization and worse neurological function outcomes. |
| first_indexed | 2024-04-24T23:04:16Z |
| format | Article |
| id | doaj.art-ebcb5656a1cd413d904dbe6690eae9e9 |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-04-24T23:04:16Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-ebcb5656a1cd413d904dbe6690eae9e92024-03-17T12:36:54ZengBMCLipids in Health and Disease1476-511X2024-03-0123111010.1186/s12944-024-02065-5Nonalcoholic fatty liver disease is an independent risk factor for ischemic stroke after revascularization in patients with Moyamoya disease: a prospective cohort studyBojian Zhang0Junsheng Li1Chaofan Zeng2Chuming Tao3Qiheng He4Chenglong Liu5Zhiyao Zheng6Zhikang Zhao7Siqi Mou8Wei Sun9Jia Wang10Qian Zhang11Rong Wang12Yan Zhang13Peicong Ge14Dong Zhang15Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Hospital, National Center of GerontologyAbstract Background The study aimed to investigate the association between nonalcoholic fatty liver disease (NAFLD) and ischemic stroke events after revascularization in patients with Moyamoya disease (MMD). Methods This study prospectively enrolled 275 MMD patients from September 2020 to December 2021. Patients with alcoholism and other liver diseases were excluded. NAFLD was confirmed by CT imaging or abdominal ultrasonography. Stroke events and modified Rankin Scale (mRS) scores at the latest follow-up were compared between the two groups. Results A total of 275 patients were enrolled in the study, among which 65 were diagnosed with NAFLD. Univariate logistic regression analysis showed that NAFLD (P = 0.029) was related to stroke events. Multivariate logistic regression analysis showed that NAFLD is a predictor of postoperative stroke in MMD patients (OR = 27.145, 95% CI = 2.031–362.81, P = 0.013). Kaplan-Meier analysis showed that compared with MMD patients with NAFLD, patients in the control group had a longer stroke-free time (P = 0.004). Univariate Cox analysis showed that NAFLD (P = 0.016) was associated with ischemic stroke during follow-up in patients with MMD. Multivariate Cox analysis showed that NAFLD was an independent risk factor for stroke in patients with MMD (HR = 10.815, 95% CI = 1.259–92.881, P = 0.030). Furthermore, fewer patients in the NAFLD group had good neurologic status (mRS score ≤ 2) than the control group (P = 0.005). Conclusion NAFLD was an independent risk factor for stroke in patients with MMD after revascularization and worse neurological function outcomes.https://doi.org/10.1186/s12944-024-02065-5Moyamoya diseaseStrokeRisk factorPrognosisNAFLD |
| spellingShingle | Bojian Zhang Junsheng Li Chaofan Zeng Chuming Tao Qiheng He Chenglong Liu Zhiyao Zheng Zhikang Zhao Siqi Mou Wei Sun Jia Wang Qian Zhang Rong Wang Yan Zhang Peicong Ge Dong Zhang Nonalcoholic fatty liver disease is an independent risk factor for ischemic stroke after revascularization in patients with Moyamoya disease: a prospective cohort study Lipids in Health and Disease Moyamoya disease Stroke Risk factor Prognosis NAFLD |
| title | Nonalcoholic fatty liver disease is an independent risk factor for ischemic stroke after revascularization in patients with Moyamoya disease: a prospective cohort study |
| title_full | Nonalcoholic fatty liver disease is an independent risk factor for ischemic stroke after revascularization in patients with Moyamoya disease: a prospective cohort study |
| title_fullStr | Nonalcoholic fatty liver disease is an independent risk factor for ischemic stroke after revascularization in patients with Moyamoya disease: a prospective cohort study |
| title_full_unstemmed | Nonalcoholic fatty liver disease is an independent risk factor for ischemic stroke after revascularization in patients with Moyamoya disease: a prospective cohort study |
| title_short | Nonalcoholic fatty liver disease is an independent risk factor for ischemic stroke after revascularization in patients with Moyamoya disease: a prospective cohort study |
| title_sort | nonalcoholic fatty liver disease is an independent risk factor for ischemic stroke after revascularization in patients with moyamoya disease a prospective cohort study |
| topic | Moyamoya disease Stroke Risk factor Prognosis NAFLD |
| url | https://doi.org/10.1186/s12944-024-02065-5 |
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