Clinical Outcome and Comparison of Regenerative and Apexification Intervention in Young Immature Necrotic Teeth—A Systematic Review and Meta-Analysis
This systematic review aimed to evaluate interventions individually and compare the clinical outcome of young, immature teeth treated with regenerative endodontic therapy (RET) and apexification procedure. The protocol was registered with PROSPERO (International Prospective Register of Systematic Re...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-07-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/11/13/3909 |
| _version_ | 1797434190304641024 |
|---|---|
| author | Pratima Panda Lora Mishra Shashirekha Govind Saurav Panda Barbara Lapinska |
| author_facet | Pratima Panda Lora Mishra Shashirekha Govind Saurav Panda Barbara Lapinska |
| author_sort | Pratima Panda |
| collection | DOAJ |
| description | This systematic review aimed to evaluate interventions individually and compare the clinical outcome of young, immature teeth treated with regenerative endodontic therapy (RET) and apexification procedure. The protocol was registered with PROSPERO (International Prospective Register of Systematic Reviews), bearing the registration number CRD42021230284. A bibliographic search in the biomedical databases was conducted in four databases—PubMed, CENTRAL, EMBASE and ProQuest—using searching keywords and was limited to studies published between January 2000 and April 2022 in English. The search was supplemented by manual searching, citation screening and scanning of all reference lists of selected paper. The study selection criteria were randomized clinical trial, prospective clinical studies and observational studies. The search found 32 eligible articles, which were included in the study. The quality assessment of the studies was performed using the Cochrane risk of bias tool for randomized control trials and non-randomized clinical studies. The meta-analysis was performed using Review Manager software (REVMAN, version 5). The results indicated that a clinicians’ MTA apexification procedure was more successful compared to calcium hydroxide. In RET, apical closure and overall success rate is statistically same for both apical platelet concentrates (APCs) and blood clots (BC). Both interventions have similar survival rates; however, RET should be preferred in cases where the root development is severely deficient, there is insufficient dentine and the tooth’s prognosis is hopeless even with an apexification procedure. |
| first_indexed | 2024-03-09T10:27:41Z |
| format | Article |
| id | doaj.art-ebcc6178db3b40be93c22a21b97904f5 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T10:27:41Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-ebcc6178db3b40be93c22a21b97904f52023-12-01T21:33:35ZengMDPI AGJournal of Clinical Medicine2077-03832022-07-011113390910.3390/jcm11133909Clinical Outcome and Comparison of Regenerative and Apexification Intervention in Young Immature Necrotic Teeth—A Systematic Review and Meta-AnalysisPratima Panda0Lora Mishra1Shashirekha Govind2Saurav Panda3Barbara Lapinska4Department of Conservative Dentistry and Endodontics, Institute of Dental Sciences, Siksha ‘O’ Anusandhan University, Bhubaneswar 751003, Odisha, IndiaDepartment of Conservative Dentistry and Endodontics, Institute of Dental Sciences, Siksha ‘O’ Anusandhan University, Bhubaneswar 751003, Odisha, IndiaDepartment of Conservative Dentistry and Endodontics, Institute of Dental Sciences, Siksha ‘O’ Anusandhan University, Bhubaneswar 751003, Odisha, IndiaDepartment of Periodontics and Oral Implantology, Institute of Dental Sciences, Siksha ‘O’ Anusandhan University, Bhubaneswar 751003, Odisha, IndiaDepartment of General Dentistry, Medical University of Lodz, 92-213 Lodz, PolandThis systematic review aimed to evaluate interventions individually and compare the clinical outcome of young, immature teeth treated with regenerative endodontic therapy (RET) and apexification procedure. The protocol was registered with PROSPERO (International Prospective Register of Systematic Reviews), bearing the registration number CRD42021230284. A bibliographic search in the biomedical databases was conducted in four databases—PubMed, CENTRAL, EMBASE and ProQuest—using searching keywords and was limited to studies published between January 2000 and April 2022 in English. The search was supplemented by manual searching, citation screening and scanning of all reference lists of selected paper. The study selection criteria were randomized clinical trial, prospective clinical studies and observational studies. The search found 32 eligible articles, which were included in the study. The quality assessment of the studies was performed using the Cochrane risk of bias tool for randomized control trials and non-randomized clinical studies. The meta-analysis was performed using Review Manager software (REVMAN, version 5). The results indicated that a clinicians’ MTA apexification procedure was more successful compared to calcium hydroxide. In RET, apical closure and overall success rate is statistically same for both apical platelet concentrates (APCs) and blood clots (BC). Both interventions have similar survival rates; however, RET should be preferred in cases where the root development is severely deficient, there is insufficient dentine and the tooth’s prognosis is hopeless even with an apexification procedure.https://www.mdpi.com/2077-0383/11/13/3909apexificationendodontic therapyimmature permanent toothpulpregeneration |
| spellingShingle | Pratima Panda Lora Mishra Shashirekha Govind Saurav Panda Barbara Lapinska Clinical Outcome and Comparison of Regenerative and Apexification Intervention in Young Immature Necrotic Teeth—A Systematic Review and Meta-Analysis Journal of Clinical Medicine apexification endodontic therapy immature permanent tooth pulp regeneration |
| title | Clinical Outcome and Comparison of Regenerative and Apexification Intervention in Young Immature Necrotic Teeth—A Systematic Review and Meta-Analysis |
| title_full | Clinical Outcome and Comparison of Regenerative and Apexification Intervention in Young Immature Necrotic Teeth—A Systematic Review and Meta-Analysis |
| title_fullStr | Clinical Outcome and Comparison of Regenerative and Apexification Intervention in Young Immature Necrotic Teeth—A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Clinical Outcome and Comparison of Regenerative and Apexification Intervention in Young Immature Necrotic Teeth—A Systematic Review and Meta-Analysis |
| title_short | Clinical Outcome and Comparison of Regenerative and Apexification Intervention in Young Immature Necrotic Teeth—A Systematic Review and Meta-Analysis |
| title_sort | clinical outcome and comparison of regenerative and apexification intervention in young immature necrotic teeth a systematic review and meta analysis |
| topic | apexification endodontic therapy immature permanent tooth pulp regeneration |
| url | https://www.mdpi.com/2077-0383/11/13/3909 |
| work_keys_str_mv | AT pratimapanda clinicaloutcomeandcomparisonofregenerativeandapexificationinterventioninyoungimmaturenecroticteethasystematicreviewandmetaanalysis AT loramishra clinicaloutcomeandcomparisonofregenerativeandapexificationinterventioninyoungimmaturenecroticteethasystematicreviewandmetaanalysis AT shashirekhagovind clinicaloutcomeandcomparisonofregenerativeandapexificationinterventioninyoungimmaturenecroticteethasystematicreviewandmetaanalysis AT sauravpanda clinicaloutcomeandcomparisonofregenerativeandapexificationinterventioninyoungimmaturenecroticteethasystematicreviewandmetaanalysis AT barbaralapinska clinicaloutcomeandcomparisonofregenerativeandapexificationinterventioninyoungimmaturenecroticteethasystematicreviewandmetaanalysis |